The interactive roles of Aedes aegypti super-production and human density in dengue transmission.
BACKGROUND: A. aegypti production and human density may vary considerably in dengue endemic areas. Understanding how interactions between these factors influence the risk of transmission could improve the effectiveness of the allocation of vector control resources. To evaluate the combined impacts o...
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ftdoajarticles:oai:doaj.org/article:784cecc729fc4e9384dfb546d450590e 2023-05-15T15:16:32+02:00 The interactive roles of Aedes aegypti super-production and human density in dengue transmission. Harish Padmanabha David Durham Fabio Correa Maria Diuk-Wasser Alison Galvani 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001799 https://doaj.org/article/784cecc729fc4e9384dfb546d450590e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3429384?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001799 1935-2727 1935-2735 https://doaj.org/article/784cecc729fc4e9384dfb546d450590e PLoS Neglected Tropical Diseases, Vol 6, Iss 8, p e1799 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001799 2022-12-31T11:46:23Z BACKGROUND: A. aegypti production and human density may vary considerably in dengue endemic areas. Understanding how interactions between these factors influence the risk of transmission could improve the effectiveness of the allocation of vector control resources. To evaluate the combined impacts of variation in A. aegypti production and human density we integrated field data with simulation modeling. METHODOLOGY/PRINCIPAL FINDINGS: Using data from seven censuses of A. aegypti pupae (2007-2009) and from demographic surveys, we developed an agent-based transmission model of the dengue transmission cycle across houses in 16 dengue-endemic urban 'patches' (1-3 city blocks each) of Armenia, Colombia. Our field data showed that 92% of pupae concentrated in only 5% of houses, defined as super-producers. Average secondary infections (R(0)) depended on infrequent, but highly explosive transmission events. These super-spreading events occurred almost exclusively when the introduced infectious person infected mosquitoes that were produced in super-productive containers. Increased human density favored R(0), and when the likelihood of human introduction of virus was incorporated into risk, a strong interaction arose between vector production and human density. Simulated intervention of super-productive containers was substantially more effective in reducing dengue risk at higher human densities. SIGNIFICANCE/CONCLUSIONS: These results show significant interactions between human population density and the natural regulatory pattern of A. aegypti in the dynamics of dengue transmission. The large epidemiological significance of super-productive containers suggests that they have the potential to influence dengue viral adaptation to mosquitoes. Human population density plays a major role in dengue transmission, due to its potential impact on human-A. aegypti contact, both within a person's home and when visiting others. The large variation in population density within typical dengue endemic cities suggests that it should be a ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 8 e1799 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Harish Padmanabha David Durham Fabio Correa Maria Diuk-Wasser Alison Galvani The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: A. aegypti production and human density may vary considerably in dengue endemic areas. Understanding how interactions between these factors influence the risk of transmission could improve the effectiveness of the allocation of vector control resources. To evaluate the combined impacts of variation in A. aegypti production and human density we integrated field data with simulation modeling. METHODOLOGY/PRINCIPAL FINDINGS: Using data from seven censuses of A. aegypti pupae (2007-2009) and from demographic surveys, we developed an agent-based transmission model of the dengue transmission cycle across houses in 16 dengue-endemic urban 'patches' (1-3 city blocks each) of Armenia, Colombia. Our field data showed that 92% of pupae concentrated in only 5% of houses, defined as super-producers. Average secondary infections (R(0)) depended on infrequent, but highly explosive transmission events. These super-spreading events occurred almost exclusively when the introduced infectious person infected mosquitoes that were produced in super-productive containers. Increased human density favored R(0), and when the likelihood of human introduction of virus was incorporated into risk, a strong interaction arose between vector production and human density. Simulated intervention of super-productive containers was substantially more effective in reducing dengue risk at higher human densities. SIGNIFICANCE/CONCLUSIONS: These results show significant interactions between human population density and the natural regulatory pattern of A. aegypti in the dynamics of dengue transmission. The large epidemiological significance of super-productive containers suggests that they have the potential to influence dengue viral adaptation to mosquitoes. Human population density plays a major role in dengue transmission, due to its potential impact on human-A. aegypti contact, both within a person's home and when visiting others. The large variation in population density within typical dengue endemic cities suggests that it should be a ... |
format |
Article in Journal/Newspaper |
author |
Harish Padmanabha David Durham Fabio Correa Maria Diuk-Wasser Alison Galvani |
author_facet |
Harish Padmanabha David Durham Fabio Correa Maria Diuk-Wasser Alison Galvani |
author_sort |
Harish Padmanabha |
title |
The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
title_short |
The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
title_full |
The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
title_fullStr |
The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
title_full_unstemmed |
The interactive roles of Aedes aegypti super-production and human density in dengue transmission. |
title_sort |
interactive roles of aedes aegypti super-production and human density in dengue transmission. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001799 https://doaj.org/article/784cecc729fc4e9384dfb546d450590e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 8, p e1799 (2012) |
op_relation |
http://europepmc.org/articles/PMC3429384?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001799 1935-2727 1935-2735 https://doaj.org/article/784cecc729fc4e9384dfb546d450590e |
op_doi |
https://doi.org/10.1371/journal.pntd.0001799 |
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PLoS Neglected Tropical Diseases |
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6 |
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8 |
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e1799 |
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