Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada
Trypsin is required in the hemagglutinin (HA) cleavage to in vitro influenza viruses activation. This HA cleavage is necessary for virus cell entry by receptor-mediated endocytosis. Bacteria in the respiratory tract are potential sources of proteases that could contribute to the cleavage of influenz...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:78287e150bf44bab95dfe9bd48228afd 2024-09-09T19:28:12+00:00 Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada Dalva Assunção Portari Mancini Rita Maria Zucatelli Mendonça Andrea Luppi Fernandes Dias Ronaldo Zucatelli Mendonça José Ricardo Pinto 2005-10-01T00:00:00Z https://doi.org/10.1590/S0036-46652005000500007 https://doaj.org/article/78287e150bf44bab95dfe9bd48228afd EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652005000500007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652005000500007 0036-4665 1678-9946 https://doaj.org/article/78287e150bf44bab95dfe9bd48228afd Revista do Instituto de Medicina Tropical de São Paulo, Vol 47, Iss 5, Pp 275-280 (2005) Stenotrophomonas maltophilia Influenza virus Co-infections in vitro Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2005 ftdoajarticles https://doi.org/10.1590/S0036-46652005000500007 2024-08-05T17:49:31Z Trypsin is required in the hemagglutinin (HA) cleavage to in vitro influenza viruses activation. This HA cleavage is necessary for virus cell entry by receptor-mediated endocytosis. Bacteria in the respiratory tract are potential sources of proteases that could contribute to the cleavage of influenza virus in vivo. From 47 samples collected from horses, pigs, and from humans, influenza presence was confirmed in 13 and these samples demonstrated co-infection of influenza with flagellated bacteria, Stenotrophomonas maltophilia from the beginning of the experiments. Despite treatment with antibiotics, the bacteria remained resistant in several of the co-infected samples (48.39%). These bacteria, considered opportunistic invaders from environmental sources, are associated with viral infections in upper respiratory tract of hosts. The protease (elastase), secreted by Stenotrophomonas maltophilia plays a role in the potentiation of influenza virus infection. Proteolytic activity was detected by casein agar test. Positive samples from animals and humans had either a potentiated influenza infectivity or cytopathic effect (CPE) in MDCK and NCI H292 cells, Stenotrophomonas maltophilia were always present. Virus and bacteria were observed ultrastructurally. These in vitro findings show that microbial proteases could contribute to respiratory complications by host protease activity increasing inflammation or destroying endogenous cell protease inhibitors. Tripsina é necessária na ativação da clivagem do vírus influenza A in vitro. Esta clivagem é importante para entrada do vírus na célula por endocitose mediada pelo receptor celular. Bactérias presentes no trato respiratório são fontes de proteases que podem contribuir na replicação do vírus influenza in vivo. Entre 47 amostras coletadas de cavalos, suínos e humanos, a influenza foi isolada e confirmada em 13 que estavam co-infectadas com bactéria flagelada: Stenotrophomonas maltophilia desde o início destes experimentos. Apesar do tratamento das amostras com antibióticos, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Entrada ENVELOPE(-60.552,-60.552,-62.998,-62.998) Revista do Instituto de Medicina Tropical de São Paulo 47 5 275 280 |
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Directory of Open Access Journals: DOAJ Articles |
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Stenotrophomonas maltophilia Influenza virus Co-infections in vitro Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Stenotrophomonas maltophilia Influenza virus Co-infections in vitro Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Dalva Assunção Portari Mancini Rita Maria Zucatelli Mendonça Andrea Luppi Fernandes Dias Ronaldo Zucatelli Mendonça José Ricardo Pinto Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
topic_facet |
Stenotrophomonas maltophilia Influenza virus Co-infections in vitro Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Trypsin is required in the hemagglutinin (HA) cleavage to in vitro influenza viruses activation. This HA cleavage is necessary for virus cell entry by receptor-mediated endocytosis. Bacteria in the respiratory tract are potential sources of proteases that could contribute to the cleavage of influenza virus in vivo. From 47 samples collected from horses, pigs, and from humans, influenza presence was confirmed in 13 and these samples demonstrated co-infection of influenza with flagellated bacteria, Stenotrophomonas maltophilia from the beginning of the experiments. Despite treatment with antibiotics, the bacteria remained resistant in several of the co-infected samples (48.39%). These bacteria, considered opportunistic invaders from environmental sources, are associated with viral infections in upper respiratory tract of hosts. The protease (elastase), secreted by Stenotrophomonas maltophilia plays a role in the potentiation of influenza virus infection. Proteolytic activity was detected by casein agar test. Positive samples from animals and humans had either a potentiated influenza infectivity or cytopathic effect (CPE) in MDCK and NCI H292 cells, Stenotrophomonas maltophilia were always present. Virus and bacteria were observed ultrastructurally. These in vitro findings show that microbial proteases could contribute to respiratory complications by host protease activity increasing inflammation or destroying endogenous cell protease inhibitors. Tripsina é necessária na ativação da clivagem do vírus influenza A in vitro. Esta clivagem é importante para entrada do vírus na célula por endocitose mediada pelo receptor celular. Bactérias presentes no trato respiratório são fontes de proteases que podem contribuir na replicação do vírus influenza in vivo. Entre 47 amostras coletadas de cavalos, suínos e humanos, a influenza foi isolada e confirmada em 13 que estavam co-infectadas com bactéria flagelada: Stenotrophomonas maltophilia desde o início destes experimentos. Apesar do tratamento das amostras com antibióticos, ... |
format |
Article in Journal/Newspaper |
author |
Dalva Assunção Portari Mancini Rita Maria Zucatelli Mendonça Andrea Luppi Fernandes Dias Ronaldo Zucatelli Mendonça José Ricardo Pinto |
author_facet |
Dalva Assunção Portari Mancini Rita Maria Zucatelli Mendonça Andrea Luppi Fernandes Dias Ronaldo Zucatelli Mendonça José Ricardo Pinto |
author_sort |
Dalva Assunção Portari Mancini |
title |
Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
title_short |
Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
title_full |
Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
title_fullStr |
Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
title_full_unstemmed |
Co-infection between influenza virus and flagellated bacteria Co-infecção entre vírus influenza e bactéria flagelada |
title_sort |
co-infection between influenza virus and flagellated bacteria co-infecção entre vírus influenza e bactéria flagelada |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2005 |
url |
https://doi.org/10.1590/S0036-46652005000500007 https://doaj.org/article/78287e150bf44bab95dfe9bd48228afd |
long_lat |
ENVELOPE(-60.552,-60.552,-62.998,-62.998) |
geographic |
Arctic Entrada |
geographic_facet |
Arctic Entrada |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 47, Iss 5, Pp 275-280 (2005) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652005000500007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652005000500007 0036-4665 1678-9946 https://doaj.org/article/78287e150bf44bab95dfe9bd48228afd |
op_doi |
https://doi.org/10.1590/S0036-46652005000500007 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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47 |
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