Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
Abstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin...
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ftdoajarticles:oai:doaj.org/article:777ac54ba0fb412ba1cf33da437f65a5 2023-05-15T15:08:40+02:00 Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release Thaís Furtado Ferreira Pollyanna da Fonseca Silva Matsuoka Alcione Miranda dos Santos Arlene de Jesus Mendes Caldas 2015-12-01T00:00:00Z https://doi.org/10.1590/0037-8682-0258-2015 https://doaj.org/article/777ac54ba0fb412ba1cf33da437f65a5 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0258-2015 https://doaj.org/article/777ac54ba0fb412ba1cf33da437f65a5 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 6, Pp 724-730 (2015) Tuberculosis Diagnosis Latent tuberculosis Interferon-gamma Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0258-2015 2022-12-30T23:24:04Z Abstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin skin testing (TST) with QuantiFERON-TB Gold In TUBE(r) in the diagnosis of LTBI in contacts of patients with active TB. METHODS: Cross-sectional analytical study with 60 contacts of patients with active pulmonary TB. A blood sample of each contact was taken for interferon-gamma release assay (IGRA) and subsequently performed the TST. A receiver operating characteristic curve was generated to assess the cutoff points and the sensitivity, predictive values, and accuracy were calculated. The agreement between IGRA and TST results was evaluated by Kappa coefficient. RESULTS: Here, 67.9% sensitivity, 84.4% specificity, 79.1% PPV, 75% NPV, and 76.7% accuracy were observed for the 5mm cutoff point. The prevalence of LTBI determined by TST and IGRA was 40% and 46.7%, respectively. CONCLUSIONS: Both QuantiFERON-TB Gold In TUBE(r) and TST showed good performance in LTBI diagnosis. The creation of specific diagnostic methods is necessary for the diagnosis of LTBI with higher sensitivity and specificity, preferably with low cost and not require a return visit for reading because with early treatment of latent forms can prevent active TB. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 6 724 730 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Tuberculosis Diagnosis Latent tuberculosis Interferon-gamma Arctic medicine. Tropical medicine RC955-962 |
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Tuberculosis Diagnosis Latent tuberculosis Interferon-gamma Arctic medicine. Tropical medicine RC955-962 Thaís Furtado Ferreira Pollyanna da Fonseca Silva Matsuoka Alcione Miranda dos Santos Arlene de Jesus Mendes Caldas Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
topic_facet |
Tuberculosis Diagnosis Latent tuberculosis Interferon-gamma Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin skin testing (TST) with QuantiFERON-TB Gold In TUBE(r) in the diagnosis of LTBI in contacts of patients with active TB. METHODS: Cross-sectional analytical study with 60 contacts of patients with active pulmonary TB. A blood sample of each contact was taken for interferon-gamma release assay (IGRA) and subsequently performed the TST. A receiver operating characteristic curve was generated to assess the cutoff points and the sensitivity, predictive values, and accuracy were calculated. The agreement between IGRA and TST results was evaluated by Kappa coefficient. RESULTS: Here, 67.9% sensitivity, 84.4% specificity, 79.1% PPV, 75% NPV, and 76.7% accuracy were observed for the 5mm cutoff point. The prevalence of LTBI determined by TST and IGRA was 40% and 46.7%, respectively. CONCLUSIONS: Both QuantiFERON-TB Gold In TUBE(r) and TST showed good performance in LTBI diagnosis. The creation of specific diagnostic methods is necessary for the diagnosis of LTBI with higher sensitivity and specificity, preferably with low cost and not require a return visit for reading because with early treatment of latent forms can prevent active TB. |
format |
Article in Journal/Newspaper |
author |
Thaís Furtado Ferreira Pollyanna da Fonseca Silva Matsuoka Alcione Miranda dos Santos Arlene de Jesus Mendes Caldas |
author_facet |
Thaís Furtado Ferreira Pollyanna da Fonseca Silva Matsuoka Alcione Miranda dos Santos Arlene de Jesus Mendes Caldas |
author_sort |
Thaís Furtado Ferreira |
title |
Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
title_short |
Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
title_full |
Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
title_fullStr |
Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
title_full_unstemmed |
Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
title_sort |
diagnosis of latent mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0258-2015 https://doaj.org/article/777ac54ba0fb412ba1cf33da437f65a5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 6, Pp 724-730 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0258-2015 https://doaj.org/article/777ac54ba0fb412ba1cf33da437f65a5 |
op_doi |
https://doi.org/10.1590/0037-8682-0258-2015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
container_issue |
6 |
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724 |
op_container_end_page |
730 |
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