Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV).
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral...
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ftdoajarticles:oai:doaj.org/article:774e302bf61645b682679ec277f03f64 2023-05-15T15:04:42+02:00 Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). Elif Karaaslan Nesibe Selma Çetin Merve Kalkan-Yazıcı Sevde Hasanoğlu Faruk Karakeçili Aykut Özdarendeli Ahmet Kalkan Ali Osman Kılıç Mehmet Ziya Doymaz 2021-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009973 https://doaj.org/article/774e302bf61645b682679ec277f03f64 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009973 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009973 https://doaj.org/article/774e302bf61645b682679ec277f03f64 PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009973 2022-12-31T16:22:28Z In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral life cycle, NP becomes a logical target for detailed viral immunology studies. In this study, humoral immunity to NP was investigated in CCHF survivors, as well as in immunized mice and rabbits. Abundant antibody response against NP was demonstrated both during natural infection in humans and following experimental immunizations in mice and rabbits. Also, cellular immune responses to recombinant NP (rNP) was detected in multispecies. This study represents the most comprehensive investigation on NP as an inducer of both humoral and cellular immunity in multiple hosts and proves that rNP is an excellent candidate warranting further immunological studies specifically on vaccine investigations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 12 e0009973 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Elif Karaaslan Nesibe Selma Çetin Merve Kalkan-Yazıcı Sevde Hasanoğlu Faruk Karakeçili Aykut Özdarendeli Ahmet Kalkan Ali Osman Kılıç Mehmet Ziya Doymaz Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral life cycle, NP becomes a logical target for detailed viral immunology studies. In this study, humoral immunity to NP was investigated in CCHF survivors, as well as in immunized mice and rabbits. Abundant antibody response against NP was demonstrated both during natural infection in humans and following experimental immunizations in mice and rabbits. Also, cellular immune responses to recombinant NP (rNP) was detected in multispecies. This study represents the most comprehensive investigation on NP as an inducer of both humoral and cellular immunity in multiple hosts and proves that rNP is an excellent candidate warranting further immunological studies specifically on vaccine investigations. |
format |
Article in Journal/Newspaper |
author |
Elif Karaaslan Nesibe Selma Çetin Merve Kalkan-Yazıcı Sevde Hasanoğlu Faruk Karakeçili Aykut Özdarendeli Ahmet Kalkan Ali Osman Kılıç Mehmet Ziya Doymaz |
author_facet |
Elif Karaaslan Nesibe Selma Çetin Merve Kalkan-Yazıcı Sevde Hasanoğlu Faruk Karakeçili Aykut Özdarendeli Ahmet Kalkan Ali Osman Kılıç Mehmet Ziya Doymaz |
author_sort |
Elif Karaaslan |
title |
Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
title_short |
Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
title_full |
Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
title_fullStr |
Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
title_full_unstemmed |
Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV). |
title_sort |
immune responses in multiple hosts to nucleocapsid protein (np) of crimean-congo hemorrhagic fever virus (cchfv). |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009973 https://doaj.org/article/774e302bf61645b682679ec277f03f64 |
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Arctic |
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Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009973 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009973 https://doaj.org/article/774e302bf61645b682679ec277f03f64 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009973 |
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PLOS Neglected Tropical Diseases |
container_volume |
15 |
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12 |
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e0009973 |
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