Antibiotic and Antifungi activity of B. cepacia originating of nosocomial environmental. Independent Service University Hospital “Antonio Patricio Alcalá”. Cumaná, Venezuela

Burkholderia cepacia is a Gram-negative and non-fermenter bacilli, known as a causal agent of opportunistic infections, as well as producer of compounds with antimicrobial activities. In the present study, the antagonism of nine (9) nosocomial isolates of B. cepacia against filamentous fungi, yeast...

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Bibliographic Details
Main Authors: Yasmina Araque, Luzmila Albarado, Sara Centeno, Vidal Rodríguez Lemoine, Juana Vitelli Flores
Format: Article in Journal/Newspaper
Language:English
Spanish
Published: Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales 2007
Subjects:
burkholderia cepacia
antibiótico
antifúngico
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Arctic
Online Access:https://doaj.org/article/77023b9e467345d98917731e513935a4
Description
Summary:Burkholderia cepacia is a Gram-negative and non-fermenter bacilli, known as a causal agent of opportunistic infections, as well as producer of compounds with antimicrobial activities. In the present study, the antagonism of nine (9) nosocomial isolates of B. cepacia against filamentous fungi, yeast and bacteria from hospital environments was evaluated. The antibacterial and antifungal detection was determined according to the double layer technique and cylindrical sections in agar, respectively. Four B. cepacia isolates (CVCM: 626, 1328, 1331 and 1332) inhibited the different bacterial species analyzed. B. cepacia CVCM 1332 inhibited five (5) of the six (6) indicators of bacterial species, with inhibition halos between 11 and 22 mm, with the exception of P. fluoresecens. Three (3) B. cepacia isolates did not show antibacterial activity. Two B. cepacia isolates inhibited the studied fungi (Fusarium solani, Penicillium citrinum, Penicillium frequentans, Aspergillus niger, Aspergillus ochoraceus, Penicillium echinulatum, Candida tropicalis, Candida famata). The species CVCM 626, 1328 and 1331 showed both antibacterial and antifungal activities. The antagonism of nosocomial B. cepacia isolates against bacteria and fungi from hospital environments was demonstrated, representing an important factor in the colonization of critical areas, facilitating the appearance of infectious symptoms in hospitalized patients.

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