Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp.
Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during...
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MDPI AG
2022
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Online Access: | https://doi.org/10.3390/md20030196 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 |
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ftdoajarticles:oai:doaj.org/article:76fea00d4e554751a6dcf80dc943ada0 2023-05-15T13:32:11+02:00 Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. Sofia Kokkaliari Kim Pham Nargess Shahbazi Laurent Calcul Lukasz Wojtas Nerida G. Wilson Alexander D. Crawford Bill J. Baker 2022-03-01T00:00:00Z https://doi.org/10.3390/md20030196 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 EN eng MDPI AG https://www.mdpi.com/1660-3397/20/3/196 https://doaj.org/toc/1660-3397 doi:10.3390/md20030196 1660-3397 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 Marine Drugs, Vol 20, Iss 196, p 196 (2022) ascidians indole alkaloids zebrafish meridianins Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.3390/md20030196 2022-12-30T19:55:30Z Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during the cruise were screened in a zebrafish-based phenotypic assay. The Synoicum sp. extract induced embryonic dysmorphology characterized by axis truncation, leading to the isolation of aminopyrimidine substituted indolone ( 1 – 4 ) and indole ( 5 – 12 ) alkaloids. While the primary bioactivity tracked with previously reported meridianins A–G ( 5 – 11 ), further investigation resulted in the isolation and characterization of australindolones A–D ( 1 – 4 ) and the previously unreported meridianin H ( 12 ). Article in Journal/Newspaper Antarc* Antarctic Antarctica Directory of Open Access Journals: DOAJ Articles Antarctic The Antarctic Marine Drugs 20 3 196 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
ascidians indole alkaloids zebrafish meridianins Biology (General) QH301-705.5 |
spellingShingle |
ascidians indole alkaloids zebrafish meridianins Biology (General) QH301-705.5 Sofia Kokkaliari Kim Pham Nargess Shahbazi Laurent Calcul Lukasz Wojtas Nerida G. Wilson Alexander D. Crawford Bill J. Baker Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
topic_facet |
ascidians indole alkaloids zebrafish meridianins Biology (General) QH301-705.5 |
description |
Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during the cruise were screened in a zebrafish-based phenotypic assay. The Synoicum sp. extract induced embryonic dysmorphology characterized by axis truncation, leading to the isolation of aminopyrimidine substituted indolone ( 1 – 4 ) and indole ( 5 – 12 ) alkaloids. While the primary bioactivity tracked with previously reported meridianins A–G ( 5 – 11 ), further investigation resulted in the isolation and characterization of australindolones A–D ( 1 – 4 ) and the previously unreported meridianin H ( 12 ). |
format |
Article in Journal/Newspaper |
author |
Sofia Kokkaliari Kim Pham Nargess Shahbazi Laurent Calcul Lukasz Wojtas Nerida G. Wilson Alexander D. Crawford Bill J. Baker |
author_facet |
Sofia Kokkaliari Kim Pham Nargess Shahbazi Laurent Calcul Lukasz Wojtas Nerida G. Wilson Alexander D. Crawford Bill J. Baker |
author_sort |
Sofia Kokkaliari |
title |
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
title_short |
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
title_full |
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
title_fullStr |
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
title_full_unstemmed |
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. |
title_sort |
australindolones, new aminopyrimidine substituted indolone alkaloids from an antarctic tunicate synoicum sp. |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/md20030196 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Marine Drugs, Vol 20, Iss 196, p 196 (2022) |
op_relation |
https://www.mdpi.com/1660-3397/20/3/196 https://doaj.org/toc/1660-3397 doi:10.3390/md20030196 1660-3397 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 |
op_doi |
https://doi.org/10.3390/md20030196 |
container_title |
Marine Drugs |
container_volume |
20 |
container_issue |
3 |
container_start_page |
196 |
_version_ |
1766024925575905280 |