Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp.
Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during...
Published in: | Marine Drugs |
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Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2022
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Subjects: | |
Online Access: | https://doi.org/10.3390/md20030196 https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0 |
Summary: | Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during the cruise were screened in a zebrafish-based phenotypic assay. The Synoicum sp. extract induced embryonic dysmorphology characterized by axis truncation, leading to the isolation of aminopyrimidine substituted indolone ( 1 – 4 ) and indole ( 5 – 12 ) alkaloids. While the primary bioactivity tracked with previously reported meridianins A–G ( 5 – 11 ), further investigation resulted in the isolation and characterization of australindolones A–D ( 1 – 4 ) and the previously unreported meridianin H ( 12 ). |
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