Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Natália Bronzatto Medolago, Adriana Camargo Ferrasi, Oswaldo Melo da Rocha, Maria Inês de Moura Campos Pardini, Rejane Maria Tommasini Grotto, Aline Faria Galvani, Giovanni Faria Silva
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2020
• Subjects: Hepatitis C; Human platelet antigens; Polymorphism; Rheumatological manifestations; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0210-2019; https://doaj.org/article/76ba7ac2a4b94ee6aebe4111368cda8b

Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS: Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS: Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.