A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic.
BACKGROUND:Aedes-borne arboviruses continue to precipitate epidemics worldwide. In Dominican Republic, the appearance of Zika virus cases that closely followed a large dengue epidemic provided an opportunity to study the different transmission drivers behind these two flaviviruses. Retrospective dat...
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ftdoajarticles:oai:doaj.org/article:768f5626b3e74c629078921ab0968a0c 2023-05-15T15:15:01+02:00 A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. Leigh R Bowman Joacim Rocklöv Axel Kroeger Piero Olliaro Ronald Skewes 2018-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006876 https://doaj.org/article/768f5626b3e74c629078921ab0968a0c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6237425?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006876 https://doaj.org/article/768f5626b3e74c629078921ab0968a0c PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006876 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006876 2022-12-31T00:16:39Z BACKGROUND:Aedes-borne arboviruses continue to precipitate epidemics worldwide. In Dominican Republic, the appearance of Zika virus cases that closely followed a large dengue epidemic provided an opportunity to study the different transmission drivers behind these two flaviviruses. Retrospective datasets were used to collect information on the populations at risk and descriptive statistics were used to describe the outbreaks on a national scale. METHODOLOGY/ PRINCIPAL FINDINGS:Expectedly, box plots showed that 75% of dengue was reported in those aged <20 years while Zika infections were more widely dispersed among the population. Dengue attack rates were marginally higher among males at 25.9 per 10,000 population vs. 21.5 per 10,000 population for females. Zika infections appeared to be highly clustered among females (73.8% (95% CI 72.6%, 75.0%; p<0.05)); age-adjusted Zika attack rates among females were 7.64 per 10,000 population compared with 2.72 per 10,000 population among males. R0 calculations stratified by sex also showed a significantly higher metric among females: 1.84 (1.82, 1.87; p<0.05) when compared to males at 1.72 (1.69, 1.75; p<0.05). However, GBS attack rates stratified by sex revealed slightly higher risk in males vs. females, at 0.62 and 0.57 per 10,000 population respectively. CONCLUSIONS/ SIGNIFICANCE:Evidence suggests little impact of existing dengue immunity on reported attack rates of Zika at the population level. Confounding of R0 and incident risk calculations by sex-specific over-reporting can alter the reliability of epidemiological metrics, which could be addressed using associated proxy syndromes or conditions to explore seemingly sex-skewed incidence. The findings indicate that community awareness campaigns, through influencing short-term health seeking behaviour, remain the most plausible mechanism behind increased reporting among women of reproductive age, although biological susceptibility cannot yet be ruled out. Media campaigns and screening are therefore ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 11 e0006876 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Leigh R Bowman Joacim Rocklöv Axel Kroeger Piero Olliaro Ronald Skewes A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Aedes-borne arboviruses continue to precipitate epidemics worldwide. In Dominican Republic, the appearance of Zika virus cases that closely followed a large dengue epidemic provided an opportunity to study the different transmission drivers behind these two flaviviruses. Retrospective datasets were used to collect information on the populations at risk and descriptive statistics were used to describe the outbreaks on a national scale. METHODOLOGY/ PRINCIPAL FINDINGS:Expectedly, box plots showed that 75% of dengue was reported in those aged <20 years while Zika infections were more widely dispersed among the population. Dengue attack rates were marginally higher among males at 25.9 per 10,000 population vs. 21.5 per 10,000 population for females. Zika infections appeared to be highly clustered among females (73.8% (95% CI 72.6%, 75.0%; p<0.05)); age-adjusted Zika attack rates among females were 7.64 per 10,000 population compared with 2.72 per 10,000 population among males. R0 calculations stratified by sex also showed a significantly higher metric among females: 1.84 (1.82, 1.87; p<0.05) when compared to males at 1.72 (1.69, 1.75; p<0.05). However, GBS attack rates stratified by sex revealed slightly higher risk in males vs. females, at 0.62 and 0.57 per 10,000 population respectively. CONCLUSIONS/ SIGNIFICANCE:Evidence suggests little impact of existing dengue immunity on reported attack rates of Zika at the population level. Confounding of R0 and incident risk calculations by sex-specific over-reporting can alter the reliability of epidemiological metrics, which could be addressed using associated proxy syndromes or conditions to explore seemingly sex-skewed incidence. The findings indicate that community awareness campaigns, through influencing short-term health seeking behaviour, remain the most plausible mechanism behind increased reporting among women of reproductive age, although biological susceptibility cannot yet be ruled out. Media campaigns and screening are therefore ... |
format |
Article in Journal/Newspaper |
author |
Leigh R Bowman Joacim Rocklöv Axel Kroeger Piero Olliaro Ronald Skewes |
author_facet |
Leigh R Bowman Joacim Rocklöv Axel Kroeger Piero Olliaro Ronald Skewes |
author_sort |
Leigh R Bowman |
title |
A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
title_short |
A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
title_full |
A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
title_fullStr |
A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
title_full_unstemmed |
A comparison of Zika and dengue outbreaks using national surveillance data in the Dominican Republic. |
title_sort |
comparison of zika and dengue outbreaks using national surveillance data in the dominican republic. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006876 https://doaj.org/article/768f5626b3e74c629078921ab0968a0c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006876 (2018) |
op_relation |
http://europepmc.org/articles/PMC6237425?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006876 https://doaj.org/article/768f5626b3e74c629078921ab0968a0c |
op_doi |
https://doi.org/10.1371/journal.pntd.0006876 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
11 |
container_start_page |
e0006876 |
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1766345412658069504 |