Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis.
Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cul...
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ftdoajarticles:oai:doaj.org/article:768960f481cb42f58a65a155a848609d 2023-05-15T15:15:17+02:00 Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. Michael S Avumegah Nilakshi T Waidyatillake Wojtek P Michalski Daniel P O'Brien Tiffanie M Nelson Eugene Athan 2020-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008172 https://doaj.org/article/768960f481cb42f58a65a155a848609d EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008172 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008172 https://doaj.org/article/768960f481cb42f58a65a155a848609d PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008172 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008172 2022-12-31T04:32:22Z Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cultivation of the bacterium, histopathology, and polymerase chain reaction (PCR). These methods, although approved by the World Health Organization (WHO), have infrastructural and resource challenges in medical centres and cell-mediated immunity (CMI) and/or serology-based tests have been suggested as easier and more appropriate for accurate assessment of the disease, especially in remote or underdeveloped areas. This study systematically reviewed and conducted a meta-analysis for all research aimed at developing cell-mediated immunity (CMI) and/or serology-based tests for M. ulcerans disease. Information for this review was searched through PubMed and Web of Science databases and identified up to June 2019. References from relevant articles and reports from the WHO Annual Meeting of the Global Buruli Ulcer Initiative were also used. Twelve studies beginning in 1952, that attempted to develop CMI and/or serology-based tests for the disease were identified. These studies addressed issues of specificity and sensitivity in context of antigen composition as well as study heterogeneity and bias. The two main types of antigenic preparations considered were pathogen-derived and recombinant protein preparations. There was slight difference in test performance when M. ulcerans recombinant proteins [positivity: 67.5%; 32.5%] or pathogen-derived [positivity: 76.0%; 24.0%] preparations were used as test antigens among BU patients. However, pathogen-derived preparations were better at differentiating between patients and control groups [odds ratio (OR) of 27.92, 95%CI: 5.05-154.28]. This was followed by tests with the recombinant proteins [OR = 1.23, 95%CI: 0.27-5.62]. Overall, study heterogeneity index, I2 was 92.4% (p = 0.000). It ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 4 e0008172 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Michael S Avumegah Nilakshi T Waidyatillake Wojtek P Michalski Daniel P O'Brien Tiffanie M Nelson Eugene Athan Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cultivation of the bacterium, histopathology, and polymerase chain reaction (PCR). These methods, although approved by the World Health Organization (WHO), have infrastructural and resource challenges in medical centres and cell-mediated immunity (CMI) and/or serology-based tests have been suggested as easier and more appropriate for accurate assessment of the disease, especially in remote or underdeveloped areas. This study systematically reviewed and conducted a meta-analysis for all research aimed at developing cell-mediated immunity (CMI) and/or serology-based tests for M. ulcerans disease. Information for this review was searched through PubMed and Web of Science databases and identified up to June 2019. References from relevant articles and reports from the WHO Annual Meeting of the Global Buruli Ulcer Initiative were also used. Twelve studies beginning in 1952, that attempted to develop CMI and/or serology-based tests for the disease were identified. These studies addressed issues of specificity and sensitivity in context of antigen composition as well as study heterogeneity and bias. The two main types of antigenic preparations considered were pathogen-derived and recombinant protein preparations. There was slight difference in test performance when M. ulcerans recombinant proteins [positivity: 67.5%; 32.5%] or pathogen-derived [positivity: 76.0%; 24.0%] preparations were used as test antigens among BU patients. However, pathogen-derived preparations were better at differentiating between patients and control groups [odds ratio (OR) of 27.92, 95%CI: 5.05-154.28]. This was followed by tests with the recombinant proteins [OR = 1.23, 95%CI: 0.27-5.62]. Overall, study heterogeneity index, I2 was 92.4% (p = 0.000). It ... |
format |
Article in Journal/Newspaper |
author |
Michael S Avumegah Nilakshi T Waidyatillake Wojtek P Michalski Daniel P O'Brien Tiffanie M Nelson Eugene Athan |
author_facet |
Michael S Avumegah Nilakshi T Waidyatillake Wojtek P Michalski Daniel P O'Brien Tiffanie M Nelson Eugene Athan |
author_sort |
Michael S Avumegah |
title |
Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
title_short |
Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
title_full |
Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
title_fullStr |
Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
title_full_unstemmed |
Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis. |
title_sort |
cell-mediated and serology-based tests for mycobacterium ulcerans disease: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008172 https://doaj.org/article/768960f481cb42f58a65a155a848609d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008172 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008172 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008172 https://doaj.org/article/768960f481cb42f58a65a155a848609d |
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https://doi.org/10.1371/journal.pntd.0008172 |
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PLOS Neglected Tropical Diseases |
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e0008172 |
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