Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria
Abstract Background There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes. The population genetic structures of P. falcipa...
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ftdoajarticles:oai:doaj.org/article:76380ca8e53f40c08ab650cc469e1aac 2023-05-15T15:09:37+02:00 Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria Looareesuwan Sornchai Krusood Srivicha Tangpukdee Noppadon Iwagami Moritoshi Susomboon Pannapa Kano Shigeyuki 2008-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-212 https://doaj.org/article/76380ca8e53f40c08ab650cc469e1aac EN eng BMC http://www.malariajournal.com/content/7/1/212 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-212 1475-2875 https://doaj.org/article/76380ca8e53f40c08ab650cc469e1aac Malaria Journal, Vol 7, Iss 1, p 212 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-212 2022-12-31T11:52:48Z Abstract Background There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes. The population genetic structures of P. falciparum isolates from patients with either severe or uncomplicated malaria were examined. Methods Twelve microsatellite DNA loci from P. falciparum were used to assess the population genetic structures of 50 isolates (i.e., 25 isolates from patients with severe malaria and 25 from patients with uncomplicated malaria) collected in the Thai-Myanmar border area between 2002 and 2005. Results Genetic diversity and effective population sizes were greater in the uncomplicated malaria group than in the severe malaria group. Evidence of genetic bottlenecks was not observed in either group. Strong linkage disequilibrium was observed in the uncomplicated malaria group. The groups demonstrated significant genetic differentiation ( P < 0.05), and allele frequencies for 3 of the 12 microsatellite loci differed significantly between the two groups. Conclusion These findings suggest that the genetic structure of P. falciparum populations in patients with severe malaria differs from that in patients with uncomplicated malaria. The microsatellite loci used in this study were presumably unrelated to antigenic features of the parasites, but, these findings suggest that some loci may influence the clinical outcome of malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 212 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Looareesuwan Sornchai Krusood Srivicha Tangpukdee Noppadon Iwagami Moritoshi Susomboon Pannapa Kano Shigeyuki Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes. The population genetic structures of P. falciparum isolates from patients with either severe or uncomplicated malaria were examined. Methods Twelve microsatellite DNA loci from P. falciparum were used to assess the population genetic structures of 50 isolates (i.e., 25 isolates from patients with severe malaria and 25 from patients with uncomplicated malaria) collected in the Thai-Myanmar border area between 2002 and 2005. Results Genetic diversity and effective population sizes were greater in the uncomplicated malaria group than in the severe malaria group. Evidence of genetic bottlenecks was not observed in either group. Strong linkage disequilibrium was observed in the uncomplicated malaria group. The groups demonstrated significant genetic differentiation ( P < 0.05), and allele frequencies for 3 of the 12 microsatellite loci differed significantly between the two groups. Conclusion These findings suggest that the genetic structure of P. falciparum populations in patients with severe malaria differs from that in patients with uncomplicated malaria. The microsatellite loci used in this study were presumably unrelated to antigenic features of the parasites, but, these findings suggest that some loci may influence the clinical outcome of malaria. |
format |
Article in Journal/Newspaper |
author |
Looareesuwan Sornchai Krusood Srivicha Tangpukdee Noppadon Iwagami Moritoshi Susomboon Pannapa Kano Shigeyuki |
author_facet |
Looareesuwan Sornchai Krusood Srivicha Tangpukdee Noppadon Iwagami Moritoshi Susomboon Pannapa Kano Shigeyuki |
author_sort |
Looareesuwan Sornchai |
title |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
title_short |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
title_full |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
title_fullStr |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
title_full_unstemmed |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria |
title_sort |
differences in genetic population structures of plasmodium falciparum isolates from patients along thai-myanmar border with severe or uncomplicated malaria |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-212 https://doaj.org/article/76380ca8e53f40c08ab650cc469e1aac |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
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Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 212 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/212 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-212 1475-2875 https://doaj.org/article/76380ca8e53f40c08ab650cc469e1aac |
op_doi |
https://doi.org/10.1186/1475-2875-7-212 |
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Malaria Journal |
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7 |
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1 |
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212 |
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1766340774697369600 |