Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study.
Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing...
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ftdoajarticles:oai:doaj.org/article:760d10865d0f4606867ef35b6afe130c 2023-05-15T15:15:31+02:00 Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. Ana E Farfán-García Aamer Imdad Chengxian Zhang Mónica Y Arias-Guerrero Nayibe T Sánchez-Álvarez Junaid Iqbal Adriana E Hernández-Gamboa James C Slaughter Oscar G Gómez-Duarte 2020-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008375 https://doaj.org/article/760d10865d0f4606867ef35b6afe130c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008375 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008375 https://doaj.org/article/760d10865d0f4606867ef35b6afe130c PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008375 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008375 2022-12-31T07:36:44Z Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10-18%) of AGE, followed by rotavirus 9.3% (6.4-12%), adenovirus 3% (1-4%), astrovirus 2.9% (0.6-5%), enterotoxigenic Escherichia coli (ETEC) 2.4% (0.4-4%), Cryptosporidium sp. 2% (0.5-4%), Campylobacter sp. 2% (0.2-4%), and Salmonella sp.1.9% (0.3 to 3.5%). Except for Cryptosporidium, all parasite infections were not associated with AGE. Three emergent diarrheagenic E. coli pathotypes were identified in cases (0.7%), including an enteroaggregative/enterotoxigenic E.coli (EAEC/ETEC), an ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 6 e0008375 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ana E Farfán-García Aamer Imdad Chengxian Zhang Mónica Y Arias-Guerrero Nayibe T Sánchez-Álvarez Junaid Iqbal Adriana E Hernández-Gamboa James C Slaughter Oscar G Gómez-Duarte Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10-18%) of AGE, followed by rotavirus 9.3% (6.4-12%), adenovirus 3% (1-4%), astrovirus 2.9% (0.6-5%), enterotoxigenic Escherichia coli (ETEC) 2.4% (0.4-4%), Cryptosporidium sp. 2% (0.5-4%), Campylobacter sp. 2% (0.2-4%), and Salmonella sp.1.9% (0.3 to 3.5%). Except for Cryptosporidium, all parasite infections were not associated with AGE. Three emergent diarrheagenic E. coli pathotypes were identified in cases (0.7%), including an enteroaggregative/enterotoxigenic E.coli (EAEC/ETEC), an ... |
format |
Article in Journal/Newspaper |
author |
Ana E Farfán-García Aamer Imdad Chengxian Zhang Mónica Y Arias-Guerrero Nayibe T Sánchez-Álvarez Junaid Iqbal Adriana E Hernández-Gamboa James C Slaughter Oscar G Gómez-Duarte |
author_facet |
Ana E Farfán-García Aamer Imdad Chengxian Zhang Mónica Y Arias-Guerrero Nayibe T Sánchez-Álvarez Junaid Iqbal Adriana E Hernández-Gamboa James C Slaughter Oscar G Gómez-Duarte |
author_sort |
Ana E Farfán-García |
title |
Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
title_short |
Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
title_full |
Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
title_fullStr |
Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
title_full_unstemmed |
Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. |
title_sort |
etiology of acute gastroenteritis among children less than 5 years of age in bucaramanga, colombia: a case-control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008375 https://doaj.org/article/760d10865d0f4606867ef35b6afe130c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008375 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008375 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008375 https://doaj.org/article/760d10865d0f4606867ef35b6afe130c |
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https://doi.org/10.1371/journal.pntd.0008375 |
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PLOS Neglected Tropical Diseases |
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