An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus
Abstract Background: In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera,...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:75b7b310b2824701857475cfaef99896 2024-09-09T19:25:54+00:00 An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus Leydy Lorena Mendoza-Tobar Herlinda Clement Iván Arenas Juan Carlos Sepulveda-Arias Jimmy Alexander Guerrero Vargas Gerardo Corzo 2024-03-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2023-0063 https://doaj.org/article/75b7b310b2824701857475cfaef99896 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100304&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v30/1678-9199-jvatitd-30-e20230063.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0063 https://doaj.org/article/75b7b310b2824701857475cfaef99896 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 30 (2024) Scorpion venom Enzymes Tityus Centruroides Phospholipase Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2024 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2023-0063 2024-08-05T17:49:48Z Abstract Background: In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity. Methods: Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity. Results: C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes. Conclusion: This information provides valuable insights into the specific enzyme diversity of each species’ venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 30 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Scorpion venom Enzymes Tityus Centruroides Phospholipase Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Scorpion venom Enzymes Tityus Centruroides Phospholipase Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Leydy Lorena Mendoza-Tobar Herlinda Clement Iván Arenas Juan Carlos Sepulveda-Arias Jimmy Alexander Guerrero Vargas Gerardo Corzo An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
topic_facet |
Scorpion venom Enzymes Tityus Centruroides Phospholipase Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Background: In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity. Methods: Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity. Results: C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes. Conclusion: This information provides valuable insights into the specific enzyme diversity of each species’ venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation. |
format |
Article in Journal/Newspaper |
author |
Leydy Lorena Mendoza-Tobar Herlinda Clement Iván Arenas Juan Carlos Sepulveda-Arias Jimmy Alexander Guerrero Vargas Gerardo Corzo |
author_facet |
Leydy Lorena Mendoza-Tobar Herlinda Clement Iván Arenas Juan Carlos Sepulveda-Arias Jimmy Alexander Guerrero Vargas Gerardo Corzo |
author_sort |
Leydy Lorena Mendoza-Tobar |
title |
An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
title_short |
An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
title_full |
An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
title_fullStr |
An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
title_full_unstemmed |
An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus |
title_sort |
overview of some enzymes from buthid scorpion venoms from colombia: centruroides margaritatus, tityus pachyurus, and tityus n. sp. aff. metuendus |
publisher |
SciELO |
publishDate |
2024 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0063 https://doaj.org/article/75b7b310b2824701857475cfaef99896 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 30 (2024) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100304&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v30/1678-9199-jvatitd-30-e20230063.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0063 https://doaj.org/article/75b7b310b2824701857475cfaef99896 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0063 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
30 |
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1809895602533695488 |