TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION
The objective: to assess treatment outcomes in tuberculosis patients with extensive drug resistance (XDR TB) treated by new anti-tuberculosis drugs in the civilian community of Arkhangelsk Region.The analysis included all cases of XDR TB registered in the civilian community of Arkhangelsk Region fro...
Published in: | Tuberculosis and lung diseases |
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Language: | Russian |
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New Terra Publishing House
2018
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Online Access: | https://doi.org/10.21292/2075-1230-2018-96-7-5-10 https://doaj.org/article/754f2776f784408cb16ecac4d54490d4 |
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ftdoajarticles:oai:doaj.org/article:754f2776f784408cb16ecac4d54490d4 2023-10-09T21:49:38+02:00 TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION Anastasiya I. Gayda Oksana M. Sveshnikova Viktoriya N. Verkhovaya Svetlana V. Makhmaeva Elena I. Nikishova Andrey O. Maryandyshev 2018-08-01T00:00:00Z https://doi.org/10.21292/2075-1230-2018-96-7-5-10 https://doaj.org/article/754f2776f784408cb16ecac4d54490d4 RU rus New Terra Publishing House https://www.tibl-journal.com/jour/article/view/1143 https://doaj.org/toc/2075-1230 https://doaj.org/toc/2542-1506 2075-1230 2542-1506 doi:10.21292/2075-1230-2018-96-7-5-10 https://doaj.org/article/754f2776f784408cb16ecac4d54490d4 Туберкулез и болезни лёгких, Vol 96, Iss 7, Pp 5-10 (2018) туберкулез с широкой лекарственной устойчивостью микобактерий лечение новые препараты Diseases of the respiratory system RC705-779 article 2018 ftdoajarticles https://doi.org/10.21292/2075-1230-2018-96-7-5-10 2023-09-10T00:45:53Z The objective: to assess treatment outcomes in tuberculosis patients with extensive drug resistance (XDR TB) treated by new anti-tuberculosis drugs in the civilian community of Arkhangelsk Region.The analysis included all cases of XDR TB registered in the civilian community of Arkhangelsk Region from November 2006 to December 2013; treatment outcomes were assessed in 21 patients who were treated by regimens containing new anti-tuberculosis drugs (bedaquiline, delamanid, linezolid, clofazimine, imipenem with amoxiclav). 16 patients were treated by regimens containing 4 new anti-tuberculosis drugs. 2 patients were treated by regimen IV containing two drugs – bedaquiline, linezolid and bedaquiline, clofazimine; and 3 patients with regimens containing bedaquiline only.From November 2006 to December 2017, 175 XDR TB patients were registered in Arkhangelsk Region. The effective chemotherapy using new drugs made 57%, and mortality made 4.7%. In-take of new anti-tuberculosis drugs was accompanied side effects of minor and moderate degree.New anti-tuberculosis drugs are to be studied further in order to work out the most effective regimens for treatment of XDR TB patients. Article in Journal/Newspaper Arkhangelsk Directory of Open Access Journals: DOAJ Articles Tuberculosis and lung diseases 96 7 5 10 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
туберкулез с широкой лекарственной устойчивостью микобактерий лечение новые препараты Diseases of the respiratory system RC705-779 |
spellingShingle |
туберкулез с широкой лекарственной устойчивостью микобактерий лечение новые препараты Diseases of the respiratory system RC705-779 Anastasiya I. Gayda Oksana M. Sveshnikova Viktoriya N. Verkhovaya Svetlana V. Makhmaeva Elena I. Nikishova Andrey O. Maryandyshev TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
topic_facet |
туберкулез с широкой лекарственной устойчивостью микобактерий лечение новые препараты Diseases of the respiratory system RC705-779 |
description |
The objective: to assess treatment outcomes in tuberculosis patients with extensive drug resistance (XDR TB) treated by new anti-tuberculosis drugs in the civilian community of Arkhangelsk Region.The analysis included all cases of XDR TB registered in the civilian community of Arkhangelsk Region from November 2006 to December 2013; treatment outcomes were assessed in 21 patients who were treated by regimens containing new anti-tuberculosis drugs (bedaquiline, delamanid, linezolid, clofazimine, imipenem with amoxiclav). 16 patients were treated by regimens containing 4 new anti-tuberculosis drugs. 2 patients were treated by regimen IV containing two drugs – bedaquiline, linezolid and bedaquiline, clofazimine; and 3 patients with regimens containing bedaquiline only.From November 2006 to December 2017, 175 XDR TB patients were registered in Arkhangelsk Region. The effective chemotherapy using new drugs made 57%, and mortality made 4.7%. In-take of new anti-tuberculosis drugs was accompanied side effects of minor and moderate degree.New anti-tuberculosis drugs are to be studied further in order to work out the most effective regimens for treatment of XDR TB patients. |
format |
Article in Journal/Newspaper |
author |
Anastasiya I. Gayda Oksana M. Sveshnikova Viktoriya N. Verkhovaya Svetlana V. Makhmaeva Elena I. Nikishova Andrey O. Maryandyshev |
author_facet |
Anastasiya I. Gayda Oksana M. Sveshnikova Viktoriya N. Verkhovaya Svetlana V. Makhmaeva Elena I. Nikishova Andrey O. Maryandyshev |
author_sort |
Anastasiya I. Gayda |
title |
TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
title_short |
TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
title_full |
TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
title_fullStr |
TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
title_full_unstemmed |
TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE USING NEW ANTI-TUBERCULOSIS DRUGS IN THE CIVILIAN COMMUNITY OF ARKHANGELSK REGION |
title_sort |
treatment of tuberculosis patients with extensive drug resistance using new anti-tuberculosis drugs in the civilian community of arkhangelsk region |
publisher |
New Terra Publishing House |
publishDate |
2018 |
url |
https://doi.org/10.21292/2075-1230-2018-96-7-5-10 https://doaj.org/article/754f2776f784408cb16ecac4d54490d4 |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_source |
Туберкулез и болезни лёгких, Vol 96, Iss 7, Pp 5-10 (2018) |
op_relation |
https://www.tibl-journal.com/jour/article/view/1143 https://doaj.org/toc/2075-1230 https://doaj.org/toc/2542-1506 2075-1230 2542-1506 doi:10.21292/2075-1230-2018-96-7-5-10 https://doaj.org/article/754f2776f784408cb16ecac4d54490d4 |
op_doi |
https://doi.org/10.21292/2075-1230-2018-96-7-5-10 |
container_title |
Tuberculosis and lung diseases |
container_volume |
96 |
container_issue |
7 |
container_start_page |
5 |
op_container_end_page |
10 |
_version_ |
1779312661857566720 |