Effects of venoms on neutrophil respiratory burst: a major inflammatory function
Abstract Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due to the release into the phagocytic vacuole, called...
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ftdoajarticles:oai:doaj.org/article:75087b6ed0df42bcaaccf35c29a36319 2023-05-15T15:11:02+02:00 Effects of venoms on neutrophil respiratory burst: a major inflammatory function Jamel El-Benna Margarita Hurtado-Nedelec Marie-Anne Gougerot-Pocidalo Pham My-Chan Dang 2021-06-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2020-0179 https://doaj.org/article/75087b6ed0df42bcaaccf35c29a36319 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100204&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0179 https://doaj.org/article/75087b6ed0df42bcaaccf35c29a36319 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) Neutrophils Venom Inflammation ROS NADPH oxidase PLA2 L-amino acid oxidase Mastoporan Parabutoporin Disintegrins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2021 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2020-0179 2022-12-31T07:52:44Z Abstract Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due to the release into the phagocytic vacuole, called phagosome, of several toxic molecules directed against microbes. Neutrophil stimulation induces release of this arsenal into the phagosome and induces the assembly at the membrane of subunits of the NAPDH oxidase, the enzyme responsible for the production of superoxide anion that gives rise to other reactive oxygen species (ROS), a process called respiratory burst. Altogether, they are responsible for the bactericidal activity of the neutrophils. Excessive activation of neutrophils can lead to extensive release of these toxic agents, inducing tissue injury and the inflammatory reaction. Envenomation, caused by different animal species (bees, wasps, scorpions, snakes etc.), is well known to induce a local and acute inflammatory reaction, characterized by recruitment and activation of leukocytes and the release of several inflammatory mediators, including prostaglandins and cytokines. Venoms contain several molecules such as enzymes (phospholipase A2, L-amino acid oxidase and proteases, among others) and peptides (disintegrins, mastoporan, parabutoporin etc.). These molecules are able to stimulate or inhibit ROS production by neutrophils. The present review article gives a general overview of the main neutrophil functions focusing on ROS production and summarizes how venoms and venom molecules can affect this function. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 27 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Neutrophils Venom Inflammation ROS NADPH oxidase PLA2 L-amino acid oxidase Mastoporan Parabutoporin Disintegrins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Neutrophils Venom Inflammation ROS NADPH oxidase PLA2 L-amino acid oxidase Mastoporan Parabutoporin Disintegrins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Jamel El-Benna Margarita Hurtado-Nedelec Marie-Anne Gougerot-Pocidalo Pham My-Chan Dang Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
topic_facet |
Neutrophils Venom Inflammation ROS NADPH oxidase PLA2 L-amino acid oxidase Mastoporan Parabutoporin Disintegrins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due to the release into the phagocytic vacuole, called phagosome, of several toxic molecules directed against microbes. Neutrophil stimulation induces release of this arsenal into the phagosome and induces the assembly at the membrane of subunits of the NAPDH oxidase, the enzyme responsible for the production of superoxide anion that gives rise to other reactive oxygen species (ROS), a process called respiratory burst. Altogether, they are responsible for the bactericidal activity of the neutrophils. Excessive activation of neutrophils can lead to extensive release of these toxic agents, inducing tissue injury and the inflammatory reaction. Envenomation, caused by different animal species (bees, wasps, scorpions, snakes etc.), is well known to induce a local and acute inflammatory reaction, characterized by recruitment and activation of leukocytes and the release of several inflammatory mediators, including prostaglandins and cytokines. Venoms contain several molecules such as enzymes (phospholipase A2, L-amino acid oxidase and proteases, among others) and peptides (disintegrins, mastoporan, parabutoporin etc.). These molecules are able to stimulate or inhibit ROS production by neutrophils. The present review article gives a general overview of the main neutrophil functions focusing on ROS production and summarizes how venoms and venom molecules can affect this function. |
format |
Article in Journal/Newspaper |
author |
Jamel El-Benna Margarita Hurtado-Nedelec Marie-Anne Gougerot-Pocidalo Pham My-Chan Dang |
author_facet |
Jamel El-Benna Margarita Hurtado-Nedelec Marie-Anne Gougerot-Pocidalo Pham My-Chan Dang |
author_sort |
Jamel El-Benna |
title |
Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
title_short |
Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
title_full |
Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
title_fullStr |
Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
title_full_unstemmed |
Effects of venoms on neutrophil respiratory burst: a major inflammatory function |
title_sort |
effects of venoms on neutrophil respiratory burst: a major inflammatory function |
publisher |
SciELO |
publishDate |
2021 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0179 https://doaj.org/article/75087b6ed0df42bcaaccf35c29a36319 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100204&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0179 https://doaj.org/article/75087b6ed0df42bcaaccf35c29a36319 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0179 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
27 |
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1766341953985708032 |