Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors.
BACKGROUND: Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in coun...
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ftdoajarticles:oai:doaj.org/article:749105e7ff62483c90a7299bda26c04e 2023-05-15T15:14:41+02:00 Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. Akira Ito Temuulen Dorjsuren Anu Davaasuren Tetsuya Yanagida Yasuhito Sako Kazuhiro Nakaya Minoru Nakao Oyun-Erdene Bat-Ochir Tsendjav Ayushkhuu Narantuya Bazarragchaa Nyamkhuu Gonchigsengee Tiaoying Li Gurbadam Agvaandaram Abmed Davaajav Chinchuluun Boldbaatar Gantigmaa Chuluunbaatar 2014-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002937 https://doaj.org/article/749105e7ff62483c90a7299bda26c04e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4063745?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002937 https://doaj.org/article/749105e7ff62483c90a7299bda26c04e PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2937 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002937 2022-12-31T15:07:50Z BACKGROUND: Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in countries where camels are present. One such country is Mongolia. METHODOLOGY/PRINCIPAL FINDINGS: Forty-three human hepatic CE cases that were confirmed histopathologically at the National Center of Pathology (NCP) in Ulaanbaatar (UB) were identified by analysis of mitochondrial cox 1 gene as being caused by either E. canadensis (n=31, 72.1%) or E. granulosus s.s. (n=12, 27.9%). The majority of the E. canadensis cases were strain G6/7 (29/31, 93.5%). Twenty three haplotypes were identified. Sixteen of 39 CE cases with data on age, sex and province of residence were citizens of UB (41.0%), with 13 of the 16 cases from UB caused by E. canadensis (G6/7) (81.3%). Among these 13 cases, nine were children (69.2%). All pediatric cases (n = 18) were due to E. canadensis with 17 of the 18 cases (94.4%) due to strain G6/7. Serum samples were available for 31 of the 43 CE cases, with 22 (71.0%) samples positive by ELISA to recombinant Antigen B8/1 (rAgB). Nine of 10 CE cases caused by E. granulosus s.s. (90.0%) and 13 of 20 CE cases by E. canadensis (G6/7) (65.0%) were seropositive. The one CE case caused by E. canadensis (G10) was seronegative. CE cases caused by E. granulosus s.s. showed higher absorbance values (median value 1.131) than those caused by E. canadensis (G6/7) (median value 0.106) (p = 0.0137). CONCLUSION/SIGNIFICANCE: The main species/strains in the study population were E. canadenis and E. granulossus s.s. with E. canadensis the predominant species identified in children. The reason why E. canadensis appears to be so common in children is unknown. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 6 e2937 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Akira Ito Temuulen Dorjsuren Anu Davaasuren Tetsuya Yanagida Yasuhito Sako Kazuhiro Nakaya Minoru Nakao Oyun-Erdene Bat-Ochir Tsendjav Ayushkhuu Narantuya Bazarragchaa Nyamkhuu Gonchigsengee Tiaoying Li Gurbadam Agvaandaram Abmed Davaajav Chinchuluun Boldbaatar Gantigmaa Chuluunbaatar Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in countries where camels are present. One such country is Mongolia. METHODOLOGY/PRINCIPAL FINDINGS: Forty-three human hepatic CE cases that were confirmed histopathologically at the National Center of Pathology (NCP) in Ulaanbaatar (UB) were identified by analysis of mitochondrial cox 1 gene as being caused by either E. canadensis (n=31, 72.1%) or E. granulosus s.s. (n=12, 27.9%). The majority of the E. canadensis cases were strain G6/7 (29/31, 93.5%). Twenty three haplotypes were identified. Sixteen of 39 CE cases with data on age, sex and province of residence were citizens of UB (41.0%), with 13 of the 16 cases from UB caused by E. canadensis (G6/7) (81.3%). Among these 13 cases, nine were children (69.2%). All pediatric cases (n = 18) were due to E. canadensis with 17 of the 18 cases (94.4%) due to strain G6/7. Serum samples were available for 31 of the 43 CE cases, with 22 (71.0%) samples positive by ELISA to recombinant Antigen B8/1 (rAgB). Nine of 10 CE cases caused by E. granulosus s.s. (90.0%) and 13 of 20 CE cases by E. canadensis (G6/7) (65.0%) were seropositive. The one CE case caused by E. canadensis (G10) was seronegative. CE cases caused by E. granulosus s.s. showed higher absorbance values (median value 1.131) than those caused by E. canadensis (G6/7) (median value 0.106) (p = 0.0137). CONCLUSION/SIGNIFICANCE: The main species/strains in the study population were E. canadenis and E. granulossus s.s. with E. canadensis the predominant species identified in children. The reason why E. canadensis appears to be so common in children is unknown. |
format |
Article in Journal/Newspaper |
author |
Akira Ito Temuulen Dorjsuren Anu Davaasuren Tetsuya Yanagida Yasuhito Sako Kazuhiro Nakaya Minoru Nakao Oyun-Erdene Bat-Ochir Tsendjav Ayushkhuu Narantuya Bazarragchaa Nyamkhuu Gonchigsengee Tiaoying Li Gurbadam Agvaandaram Abmed Davaajav Chinchuluun Boldbaatar Gantigmaa Chuluunbaatar |
author_facet |
Akira Ito Temuulen Dorjsuren Anu Davaasuren Tetsuya Yanagida Yasuhito Sako Kazuhiro Nakaya Minoru Nakao Oyun-Erdene Bat-Ochir Tsendjav Ayushkhuu Narantuya Bazarragchaa Nyamkhuu Gonchigsengee Tiaoying Li Gurbadam Agvaandaram Abmed Davaajav Chinchuluun Boldbaatar Gantigmaa Chuluunbaatar |
author_sort |
Akira Ito |
title |
Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
title_short |
Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
title_full |
Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
title_fullStr |
Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
title_full_unstemmed |
Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors. |
title_sort |
cystic echinococcoses in mongolia: molecular identification, serology and risk factors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002937 https://doaj.org/article/749105e7ff62483c90a7299bda26c04e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2937 (2014) |
op_relation |
http://europepmc.org/articles/PMC4063745?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002937 https://doaj.org/article/749105e7ff62483c90a7299bda26c04e |
op_doi |
https://doi.org/10.1371/journal.pntd.0002937 |
container_title |
PLoS Neglected Tropical Diseases |
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8 |
container_issue |
6 |
container_start_page |
e2937 |
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