Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions
Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory st...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
|
Subjects: | |
Online Access: | https://doi.org/10.1590/0037-8682-0474-2016 https://doaj.org/article/743082d0a1974af29e5eb4b5f1f901d5 |
id |
ftdoajarticles:oai:doaj.org/article:743082d0a1974af29e5eb4b5f1f901d5 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:743082d0a1974af29e5eb4b5f1f901d5 2023-05-15T15:11:01+02:00 Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira https://doi.org/10.1590/0037-8682-0474-2016 https://doaj.org/article/743082d0a1974af29e5eb4b5f1f901d5 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300334&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0474-2016 https://doaj.org/article/743082d0a1974af29e5eb4b5f1f901d5 Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 3, Pp 334-340 Chagas disease Pharmaceutical care Pharmacotherapy Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0474-2016 2022-12-31T03:21:41Z Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada. RESULTS: The average age of patients with Chagas disease was 62 years, with the majority residing in the Ceará countryside (86.7%), and having low education levels (63.3% with elementary school education). Regarding family income, most patients belonged to a household that earned ≤1-2 times the minimum wage per month. Approximately 73% of these patients complied with the BNZ treatment, and nearly 7% underwent therapy interruption after medical evaluation. A total of 189 DRPs were identified, of which 51.9% (n=98) were classified as potential, and 48.1% (n=91) as actual. The most frequent DRPs were related to safety (qualitative safety; n=70; 37%), necessity (non-adherence; n=52; 27.5%), and effectiveness (qualitative effectiveness/non-optimal drug selection; n=45; 23.8%). Among the 216 PIs conducted, the majority were related to patient education (n=168; 77.8%) and pharmacological strategy (n=42; 19.4%). CONCLUSIONS: This study indicates the need for pharmacotherapeutic monitoring in patients with Chagas because of the high number of therapeutic interventions, DRPs (approximately 3 DRPs/patient), BNZ adherence, and polypharmacy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 3 334 340 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Pharmaceutical care Pharmacotherapy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Chagas disease Pharmaceutical care Pharmacotherapy Arctic medicine. Tropical medicine RC955-962 João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
topic_facet |
Chagas disease Pharmaceutical care Pharmacotherapy Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada. RESULTS: The average age of patients with Chagas disease was 62 years, with the majority residing in the Ceará countryside (86.7%), and having low education levels (63.3% with elementary school education). Regarding family income, most patients belonged to a household that earned ≤1-2 times the minimum wage per month. Approximately 73% of these patients complied with the BNZ treatment, and nearly 7% underwent therapy interruption after medical evaluation. A total of 189 DRPs were identified, of which 51.9% (n=98) were classified as potential, and 48.1% (n=91) as actual. The most frequent DRPs were related to safety (qualitative safety; n=70; 37%), necessity (non-adherence; n=52; 27.5%), and effectiveness (qualitative effectiveness/non-optimal drug selection; n=45; 23.8%). Among the 216 PIs conducted, the majority were related to patient education (n=168; 77.8%) and pharmacological strategy (n=42; 19.4%). CONCLUSIONS: This study indicates the need for pharmacotherapeutic monitoring in patients with Chagas because of the high number of therapeutic interventions, DRPs (approximately 3 DRPs/patient), BNZ adherence, and polypharmacy. |
format |
Article in Journal/Newspaper |
author |
João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira |
author_facet |
João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira |
author_sort |
João Paulo Ramalho Correia |
title |
Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
title_short |
Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
title_full |
Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
title_fullStr |
Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
title_full_unstemmed |
Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
title_sort |
pharmacotherapeutic follow-up of patients with chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0474-2016 https://doaj.org/article/743082d0a1974af29e5eb4b5f1f901d5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 3, Pp 334-340 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300334&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0474-2016 https://doaj.org/article/743082d0a1974af29e5eb4b5f1f901d5 |
op_doi |
https://doi.org/10.1590/0037-8682-0474-2016 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
50 |
container_issue |
3 |
container_start_page |
334 |
op_container_end_page |
340 |
_version_ |
1766341943344758784 |