Improving neurodevelopment in Zika-exposed children: A randomized controlled trial.
Background While microcephaly is a significant adverse outcome of prenatal exposure to the Zika virus (ZIKV), subtle malformations of cortical development (MCD) have been observed in Zika-exposed children (ZEC), including delays in language, cognition, and motor domains, and visual acuity deficits....
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ftdoajarticles:oai:doaj.org/article:740e90687f4141c9b42f7f95058c57df 2023-05-15T15:16:30+02:00 Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. Randall Waechter Kemi S Burgen Bianca Punch Roberta Evans Karen Blackmon Trevor Noël Michelle Fernandes Barbara Landon 2022-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010263 https://doaj.org/article/740e90687f4141c9b42f7f95058c57df EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010263 https://doaj.org/article/740e90687f4141c9b42f7f95058c57df PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010263 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010263 2023-02-12T01:27:53Z Background While microcephaly is a significant adverse outcome of prenatal exposure to the Zika virus (ZIKV), subtle malformations of cortical development (MCD) have been observed in Zika-exposed children (ZEC), including delays in language, cognition, and motor domains, and visual acuity deficits. Interventions within the first 1,000 days of life can significantly improve developmental outcomes. This study examined a 12-week Responsive Caregiving Intervention on neurodevelopmental outcomes in 24-30-month-old ZEC. Methodology/principal findings A randomized controlled trial was implemented in Grenada, West Indies using an existing ZIKV cohort surveillance study. When children in that study turned 24 months, baseline child neurodevelopmental measures and caregiver interviews were administered. Caregivers who agreed to participate in the 12-week Responsive Caregiving Intervention, implemented when children were 24-30 months of age, were randomly assigned to the Intervention or Waitlist Control group. Children in both groups were re-assessed on the neurodevelopmental measures post-intervention. Conclusions/significance 233 children from the ZIKV surveillance study met inclusion criteria, of which n = 80 declined participation, n = 42 did not complete the Intervention, and n = 72 missed follow-up assessments given strict timelines in the study design. The final sample for analysis was N = 13 children in the Intervention group and N = 26 children in the Control group. A GEE model analysis showed significantly higher language (p = 0.021) and positive behaviour (p = 0.005) scores for children in the Intervention group compared to the Control group. The Intervention had a medium effect on child language (d = 0.66) and a large effect on positive behaviour (d = 0.83). A 12-week Responsive Caregiving Intervention Programme significantly improves language and positive behaviour scores in 30-month-old normocephalic children who were exposed to ZIKV in utero. The programme provides an option for mothers of ZIKV-exposed ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 3 e0010263 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Randall Waechter Kemi S Burgen Bianca Punch Roberta Evans Karen Blackmon Trevor Noël Michelle Fernandes Barbara Landon Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background While microcephaly is a significant adverse outcome of prenatal exposure to the Zika virus (ZIKV), subtle malformations of cortical development (MCD) have been observed in Zika-exposed children (ZEC), including delays in language, cognition, and motor domains, and visual acuity deficits. Interventions within the first 1,000 days of life can significantly improve developmental outcomes. This study examined a 12-week Responsive Caregiving Intervention on neurodevelopmental outcomes in 24-30-month-old ZEC. Methodology/principal findings A randomized controlled trial was implemented in Grenada, West Indies using an existing ZIKV cohort surveillance study. When children in that study turned 24 months, baseline child neurodevelopmental measures and caregiver interviews were administered. Caregivers who agreed to participate in the 12-week Responsive Caregiving Intervention, implemented when children were 24-30 months of age, were randomly assigned to the Intervention or Waitlist Control group. Children in both groups were re-assessed on the neurodevelopmental measures post-intervention. Conclusions/significance 233 children from the ZIKV surveillance study met inclusion criteria, of which n = 80 declined participation, n = 42 did not complete the Intervention, and n = 72 missed follow-up assessments given strict timelines in the study design. The final sample for analysis was N = 13 children in the Intervention group and N = 26 children in the Control group. A GEE model analysis showed significantly higher language (p = 0.021) and positive behaviour (p = 0.005) scores for children in the Intervention group compared to the Control group. The Intervention had a medium effect on child language (d = 0.66) and a large effect on positive behaviour (d = 0.83). A 12-week Responsive Caregiving Intervention Programme significantly improves language and positive behaviour scores in 30-month-old normocephalic children who were exposed to ZIKV in utero. The programme provides an option for mothers of ZIKV-exposed ... |
format |
Article in Journal/Newspaper |
author |
Randall Waechter Kemi S Burgen Bianca Punch Roberta Evans Karen Blackmon Trevor Noël Michelle Fernandes Barbara Landon |
author_facet |
Randall Waechter Kemi S Burgen Bianca Punch Roberta Evans Karen Blackmon Trevor Noël Michelle Fernandes Barbara Landon |
author_sort |
Randall Waechter |
title |
Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
title_short |
Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
title_full |
Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
title_fullStr |
Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
title_full_unstemmed |
Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. |
title_sort |
improving neurodevelopment in zika-exposed children: a randomized controlled trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010263 https://doaj.org/article/740e90687f4141c9b42f7f95058c57df |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010263 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010263 https://doaj.org/article/740e90687f4141c9b42f7f95058c57df |
op_doi |
https://doi.org/10.1371/journal.pntd.0010263 |
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PLOS Neglected Tropical Diseases |
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16 |
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3 |
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e0010263 |
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