Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies
Abstract Background Malaria and dengue fever are the leading causes of acute, undifferentiated febrile illness. In Africa, misdiagnosis of dengue fever as malaria is a common scenario. Through a systematic review of the published literature, this study seeks to estimate the prevalence of dengue and...
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ftdoajarticles:oai:doaj.org/article:73ec05e324f54861b3aafe5e98ea44ad 2023-12-10T09:46:08+01:00 Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies Tewelde T. Gebremariam Henk D. F. H. Schallig Zeleke M. Kurmane Jonas B. Danquah 2023-10-01T00:00:00Z https://doi.org/10.1186/s12936-023-04723-y https://doaj.org/article/73ec05e324f54861b3aafe5e98ea44ad EN eng BMC https://doi.org/10.1186/s12936-023-04723-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04723-y 1475-2875 https://doaj.org/article/73ec05e324f54861b3aafe5e98ea44ad Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023) Prevalence Malaria Dengue fever Dengue virus Plasmodium falciparum Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04723-y 2023-11-12T01:40:53Z Abstract Background Malaria and dengue fever are the leading causes of acute, undifferentiated febrile illness. In Africa, misdiagnosis of dengue fever as malaria is a common scenario. Through a systematic review of the published literature, this study seeks to estimate the prevalence of dengue and malaria coinfection among acute undifferentiated febrile diseases in Africa. Methods Relevant publications were systematically searched in the PubMed, Cochrane Library, and Google Scholar until May 19, 2023. A random-effects meta-analysis and meta-regression were used to summarize and examine the prevalence estimates. Results Twenty-two studies with 22,803 acute undifferentiated febrile patients from 10 countries in Africa were included. The meta-analysis findings revealed a pooled prevalence of malaria and dengue coinfection of 4.2%, with Central Africa having the highest rate (4.7%), followed by East Africa (2.7%) and West Africa (1.6%). Continent-wide, Plasmodium falciparum and acute dengue virus coinfection prevalence increased significantly from 0.9% during 2008–2013 to 3.8% during 2014–2017 and to 5.5% during 2018–2021 (p = 0.0414). Conclusion There was a high and increasing prevalence of malaria and acute dengue virus coinfection in Africa. Healthcare workers should bear in mind the possibility of dengue infection as a differential diagnosis for acute febrile illness, as well as the possibility of coexisting malaria and dengue in endemic areas. In addition, high-quality multicentre studies are required to verify the above conclusions. Protocol registration number: CRD42022311301. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Prevalence Malaria Dengue fever Dengue virus Plasmodium falciparum Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Prevalence Malaria Dengue fever Dengue virus Plasmodium falciparum Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Tewelde T. Gebremariam Henk D. F. H. Schallig Zeleke M. Kurmane Jonas B. Danquah Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
topic_facet |
Prevalence Malaria Dengue fever Dengue virus Plasmodium falciparum Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria and dengue fever are the leading causes of acute, undifferentiated febrile illness. In Africa, misdiagnosis of dengue fever as malaria is a common scenario. Through a systematic review of the published literature, this study seeks to estimate the prevalence of dengue and malaria coinfection among acute undifferentiated febrile diseases in Africa. Methods Relevant publications were systematically searched in the PubMed, Cochrane Library, and Google Scholar until May 19, 2023. A random-effects meta-analysis and meta-regression were used to summarize and examine the prevalence estimates. Results Twenty-two studies with 22,803 acute undifferentiated febrile patients from 10 countries in Africa were included. The meta-analysis findings revealed a pooled prevalence of malaria and dengue coinfection of 4.2%, with Central Africa having the highest rate (4.7%), followed by East Africa (2.7%) and West Africa (1.6%). Continent-wide, Plasmodium falciparum and acute dengue virus coinfection prevalence increased significantly from 0.9% during 2008–2013 to 3.8% during 2014–2017 and to 5.5% during 2018–2021 (p = 0.0414). Conclusion There was a high and increasing prevalence of malaria and acute dengue virus coinfection in Africa. Healthcare workers should bear in mind the possibility of dengue infection as a differential diagnosis for acute febrile illness, as well as the possibility of coexisting malaria and dengue in endemic areas. In addition, high-quality multicentre studies are required to verify the above conclusions. Protocol registration number: CRD42022311301. |
format |
Article in Journal/Newspaper |
author |
Tewelde T. Gebremariam Henk D. F. H. Schallig Zeleke M. Kurmane Jonas B. Danquah |
author_facet |
Tewelde T. Gebremariam Henk D. F. H. Schallig Zeleke M. Kurmane Jonas B. Danquah |
author_sort |
Tewelde T. Gebremariam |
title |
Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
title_short |
Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
title_full |
Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
title_fullStr |
Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
title_full_unstemmed |
Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies |
title_sort |
increasing prevalence of malaria and acute dengue virus coinfection in africa: a meta-analysis and meta-regression of cross-sectional studies |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04723-y https://doaj.org/article/73ec05e324f54861b3aafe5e98ea44ad |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04723-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04723-y 1475-2875 https://doaj.org/article/73ec05e324f54861b3aafe5e98ea44ad |
op_doi |
https://doi.org/10.1186/s12936-023-04723-y |
container_title |
Malaria Journal |
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22 |
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1 |
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1784889457737990144 |