Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years.
BACKGROUND:Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis can cause life-threatening disease, there is no global burden of disease estimate in ter...
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ftdoajarticles:oai:doaj.org/article:73eb17ef98494bd5b611d15f887a9c88 2023-05-15T15:10:52+02:00 Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. Paul R Torgerson José E Hagan Federico Costa Juan Calcagno Michael Kane Martha S Martinez-Silveira Marga G A Goris Claudia Stein Albert I Ko Bernadette Abela-Ridder 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004122 https://doaj.org/article/73eb17ef98494bd5b611d15f887a9c88 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4591975?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004122 https://doaj.org/article/73eb17ef98494bd5b611d15f887a9c88 PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004122 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004122 2022-12-31T05:15:17Z BACKGROUND:Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis can cause life-threatening disease, there is no global burden of disease estimate in terms of Disability Adjusted Life Years (DALYs) available. METHODOLOGY/PRINCIPAL FINDINGS:We utilised the results of a parallel publication that reported global estimates of morbidity and mortality due to leptospirosis. We estimated Years of Life Lost (YLLs) from age and gender stratified mortality rates. Years of Life with Disability (YLDs) were developed from a simple disease model indicating likely sequelae. DALYs were estimated from the sum of YLLs and YLDs. The study suggested that globally approximately 2.90 million DALYs are lost per annum (UIs 1.25-4.54 million) from the approximately annual 1.03 million cases reported previously. Males are predominantly affected with an estimated 2.33 million DALYs (UIs 0.98-3.69) or approximately 80% of the total burden. For comparison, this is over 70% of the global burden of cholera estimated by GBD 2010. Tropical regions of South and South-east Asia, Western Pacific, Central and South America, and Africa had the highest estimated leptospirosis disease burden. CONCLUSIONS/SIGNIFICANCE:Leptospirosis imparts a significant health burden worldwide, which approach or exceed those encountered for a number of other zoonotic and neglected tropical diseases. The study findings indicate that highest burden estimates occur in resource-poor tropical countries, which include regions of Africa where the burden of leptospirosis has been under-appreciated and possibly misallocated to other febrile illnesses such as malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific Uis ENVELOPE(141.975,141.975,60.184,60.184) PLOS Neglected Tropical Diseases 9 10 e0004122 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Paul R Torgerson José E Hagan Federico Costa Juan Calcagno Michael Kane Martha S Martinez-Silveira Marga G A Goris Claudia Stein Albert I Ko Bernadette Abela-Ridder Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis can cause life-threatening disease, there is no global burden of disease estimate in terms of Disability Adjusted Life Years (DALYs) available. METHODOLOGY/PRINCIPAL FINDINGS:We utilised the results of a parallel publication that reported global estimates of morbidity and mortality due to leptospirosis. We estimated Years of Life Lost (YLLs) from age and gender stratified mortality rates. Years of Life with Disability (YLDs) were developed from a simple disease model indicating likely sequelae. DALYs were estimated from the sum of YLLs and YLDs. The study suggested that globally approximately 2.90 million DALYs are lost per annum (UIs 1.25-4.54 million) from the approximately annual 1.03 million cases reported previously. Males are predominantly affected with an estimated 2.33 million DALYs (UIs 0.98-3.69) or approximately 80% of the total burden. For comparison, this is over 70% of the global burden of cholera estimated by GBD 2010. Tropical regions of South and South-east Asia, Western Pacific, Central and South America, and Africa had the highest estimated leptospirosis disease burden. CONCLUSIONS/SIGNIFICANCE:Leptospirosis imparts a significant health burden worldwide, which approach or exceed those encountered for a number of other zoonotic and neglected tropical diseases. The study findings indicate that highest burden estimates occur in resource-poor tropical countries, which include regions of Africa where the burden of leptospirosis has been under-appreciated and possibly misallocated to other febrile illnesses such as malaria. |
format |
Article in Journal/Newspaper |
author |
Paul R Torgerson José E Hagan Federico Costa Juan Calcagno Michael Kane Martha S Martinez-Silveira Marga G A Goris Claudia Stein Albert I Ko Bernadette Abela-Ridder |
author_facet |
Paul R Torgerson José E Hagan Federico Costa Juan Calcagno Michael Kane Martha S Martinez-Silveira Marga G A Goris Claudia Stein Albert I Ko Bernadette Abela-Ridder |
author_sort |
Paul R Torgerson |
title |
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
title_short |
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
title_full |
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
title_fullStr |
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
title_full_unstemmed |
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. |
title_sort |
global burden of leptospirosis: estimated in terms of disability adjusted life years. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0004122 https://doaj.org/article/73eb17ef98494bd5b611d15f887a9c88 |
long_lat |
ENVELOPE(141.975,141.975,60.184,60.184) |
geographic |
Arctic Pacific Uis |
geographic_facet |
Arctic Pacific Uis |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004122 (2015) |
op_relation |
http://europepmc.org/articles/PMC4591975?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004122 https://doaj.org/article/73eb17ef98494bd5b611d15f887a9c88 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004122 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
10 |
container_start_page |
e0004122 |
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1766341806006468608 |