Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas...
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ftdoajarticles:oai:doaj.org/article:73e96147f7fb4765a28e07472f4a39fa 2023-05-15T18:05:02+02:00 Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou 2018-12-01T00:00:00Z https://doi.org/10.1186/s13104-018-3984-3 https://doaj.org/article/73e96147f7fb4765a28e07472f4a39fa EN eng BMC http://link.springer.com/article/10.1186/s13104-018-3984-3 https://doaj.org/toc/1756-0500 doi:10.1186/s13104-018-3984-3 1756-0500 https://doaj.org/article/73e96147f7fb4765a28e07472f4a39fa BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018) Plague Rattus rattus F1 antigen Madagascar Outbreak Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 article 2018 ftdoajarticles https://doi.org/10.1186/s13104-018-3984-3 2022-12-31T01:27:32Z Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. Results Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles BMC Research Notes 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Plague Rattus rattus F1 antigen Madagascar Outbreak Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 |
spellingShingle |
Plague Rattus rattus F1 antigen Madagascar Outbreak Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
topic_facet |
Plague Rattus rattus F1 antigen Madagascar Outbreak Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 |
description |
Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. Results Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. |
format |
Article in Journal/Newspaper |
author |
Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou |
author_facet |
Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou |
author_sort |
Voahangy Andrianaivoarimanana |
title |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_short |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_full |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_fullStr |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_full_unstemmed |
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
title_sort |
exposure to yersinia pestis increases resistance to plague in black rats and modulates transmission in madagascar |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s13104-018-3984-3 https://doaj.org/article/73e96147f7fb4765a28e07472f4a39fa |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s13104-018-3984-3 https://doaj.org/toc/1756-0500 doi:10.1186/s13104-018-3984-3 1756-0500 https://doaj.org/article/73e96147f7fb4765a28e07472f4a39fa |
op_doi |
https://doi.org/10.1186/s13104-018-3984-3 |
container_title |
BMC Research Notes |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766176468225753088 |