Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil
Introduction The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present...
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ftdoajarticles:oai:doaj.org/article:73e554304acb43ad94979c08b0cd119e 2023-05-15T15:10:43+02:00 Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil Vanessa Wolff Machado Pedro Fernando da Costa Vasconcelos Eliana Vieira Pinto Silva João Barberino Santos 2013-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0007-2012 https://doaj.org/article/73e554304acb43ad94979c08b0cd119e EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200166&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0007-2012 https://doaj.org/article/73e554304acb43ad94979c08b0cd119e Revista da Sociedade Brasileira de Medicina Tropical, Vol 46, Iss 2, Pp 166-171 (2013) Yellow fever Vaccine protection Luziânia Goiás Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1590/0037-8682-0007-2012 2022-12-31T02:57:09Z Introduction The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results We found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 46 2 166 171 |
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Yellow fever Vaccine protection Luziânia Goiás Arctic medicine. Tropical medicine RC955-962 |
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Yellow fever Vaccine protection Luziânia Goiás Arctic medicine. Tropical medicine RC955-962 Vanessa Wolff Machado Pedro Fernando da Costa Vasconcelos Eliana Vieira Pinto Silva João Barberino Santos Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
topic_facet |
Yellow fever Vaccine protection Luziânia Goiás Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results We found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas. |
format |
Article in Journal/Newspaper |
author |
Vanessa Wolff Machado Pedro Fernando da Costa Vasconcelos Eliana Vieira Pinto Silva João Barberino Santos |
author_facet |
Vanessa Wolff Machado Pedro Fernando da Costa Vasconcelos Eliana Vieira Pinto Silva João Barberino Santos |
author_sort |
Vanessa Wolff Machado |
title |
Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
title_short |
Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
title_full |
Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
title_fullStr |
Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
title_full_unstemmed |
Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil |
title_sort |
serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in central brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2013 |
url |
https://doi.org/10.1590/0037-8682-0007-2012 https://doaj.org/article/73e554304acb43ad94979c08b0cd119e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 46, Iss 2, Pp 166-171 (2013) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200166&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0007-2012 https://doaj.org/article/73e554304acb43ad94979c08b0cd119e |
op_doi |
https://doi.org/10.1590/0037-8682-0007-2012 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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46 |
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166 |
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