Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study.
BACKGROUND:Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population. METHODS:CK and h...
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ftdoajarticles:oai:doaj.org/article:737519dfeae3443fbc0005948f4d91d8 2023-05-15T18:34:27+02:00 Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. Svein Ivar Bekkelund Stein Harald Johnsen 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0198133 https://doaj.org/article/737519dfeae3443fbc0005948f4d91d8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5973606?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0198133 https://doaj.org/article/737519dfeae3443fbc0005948f4d91d8 PLoS ONE, Vol 13, Iss 5, p e0198133 (2018) Medicine R Science Q article 2018 ftdoajarticles https://doi.org/10.1371/journal.pone.0198133 2022-12-30T23:16:08Z BACKGROUND:Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population. METHODS:CK and hs-CRP were measured in the population-based Tromsø study that included entire birth cohorts and random samples of citizens between 30-87 years of age. The analyses were performed sex-stratified in 5969 men and 6827 women. RESULTS:CK correlated negatively with hs-CRP in men (r = -0.08, P <0.001) and women (r = -0.06, P <0.001). In univariable regression analyses, CK associated negatively with hs-CRP in men (ß = -0.14, 95% CI -0.19 to -0.10, P <0.001) and women (ß = -0.13, 95% CI -0.18 to -0.08, P <0.001). Mean CK declined from the 2. to the 4. quartiles of hs-CRP in both genders (P <0.001 for trends). There were positive correlations between CK and body mass index (BMI) in men (r = 0.10, P <0.001) and women (r = 0.07, P <0.001). Multiple regression analyses showed a 0.13 unit decrease in hs-CRP (mg/dl) per unit CK increase in men (95% CI -0.35 to -0.20) and 0.29 mg/dl in women (95% CI -0.36 to -0.21) when adjusted for age, BMI, lipids, s-glucose, s-creatinine, transaminases and coronary heart disease. CONCLUSION:CK were inversely and independently associated with hs-CRP in a general population. These data provide evidence that CK might have anti-inflammatory properties, but the mechanism and clinical implications are unclarified. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø PLOS ONE 13 5 e0198133 |
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Medicine R Science Q Svein Ivar Bekkelund Stein Harald Johnsen Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
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Medicine R Science Q |
description |
BACKGROUND:Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population. METHODS:CK and hs-CRP were measured in the population-based Tromsø study that included entire birth cohorts and random samples of citizens between 30-87 years of age. The analyses were performed sex-stratified in 5969 men and 6827 women. RESULTS:CK correlated negatively with hs-CRP in men (r = -0.08, P <0.001) and women (r = -0.06, P <0.001). In univariable regression analyses, CK associated negatively with hs-CRP in men (ß = -0.14, 95% CI -0.19 to -0.10, P <0.001) and women (ß = -0.13, 95% CI -0.18 to -0.08, P <0.001). Mean CK declined from the 2. to the 4. quartiles of hs-CRP in both genders (P <0.001 for trends). There were positive correlations between CK and body mass index (BMI) in men (r = 0.10, P <0.001) and women (r = 0.07, P <0.001). Multiple regression analyses showed a 0.13 unit decrease in hs-CRP (mg/dl) per unit CK increase in men (95% CI -0.35 to -0.20) and 0.29 mg/dl in women (95% CI -0.36 to -0.21) when adjusted for age, BMI, lipids, s-glucose, s-creatinine, transaminases and coronary heart disease. CONCLUSION:CK were inversely and independently associated with hs-CRP in a general population. These data provide evidence that CK might have anti-inflammatory properties, but the mechanism and clinical implications are unclarified. |
format |
Article in Journal/Newspaper |
author |
Svein Ivar Bekkelund Stein Harald Johnsen |
author_facet |
Svein Ivar Bekkelund Stein Harald Johnsen |
author_sort |
Svein Ivar Bekkelund |
title |
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
title_short |
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
title_full |
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
title_fullStr |
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
title_full_unstemmed |
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study. |
title_sort |
creatine kinase is associated with reduced inflammation in a general population: the tromsø study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pone.0198133 https://doaj.org/article/737519dfeae3443fbc0005948f4d91d8 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS ONE, Vol 13, Iss 5, p e0198133 (2018) |
op_relation |
http://europepmc.org/articles/PMC5973606?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0198133 https://doaj.org/article/737519dfeae3443fbc0005948f4d91d8 |
op_doi |
https://doi.org/10.1371/journal.pone.0198133 |
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PLOS ONE |
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13 |
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5 |
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