Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial
Objective: To compare effect of Hypericum perforatum (H. perforatum) vaginal gel with metronidazole on bacterial vaginosis (BV) in terms of initial response to treatment and preventing recurrence (primary outcomes) and also patient complaints (secondary outcomes). Methods: In this double-blind, doub...
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Wolters Kluwer Medknow Publications
2014
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Online Access: | https://doi.org/10.12980/APJTB.4.201414B160 https://doaj.org/article/73686bdb8c054deea3b9598e6489524c |
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ftdoajarticles:oai:doaj.org/article:73686bdb8c054deea3b9598e6489524c 2023-05-15T15:11:23+02:00 Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial Sakineh Mohammad-Alizadeh-Charandabi Zahra Mohammadzadeh Azizeh Farshbaf-Khalili Yousef Javadzadeh 2014-11-01T00:00:00Z https://doi.org/10.12980/APJTB.4.201414B160 https://doaj.org/article/73686bdb8c054deea3b9598e6489524c EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S222116911530037X https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.201414B160 https://doaj.org/article/73686bdb8c054deea3b9598e6489524c Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 11, Pp 896-902 (2014) Hypericum Metronidazole Vaginosis Bacterial Therapy Recurrence Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.201414B160 2022-12-31T08:16:22Z Objective: To compare effect of Hypericum perforatum (H. perforatum) vaginal gel with metronidazole on bacterial vaginosis (BV) in terms of initial response to treatment and preventing recurrence (primary outcomes) and also patient complaints (secondary outcomes). Methods: In this double-blind, double dummy trial, married women aged 18–49 with BV were randomized into two groups and administered 5 g of 3% H. perforatum and placebo of metronidazole (n=82), or 5 g of 0.75% metronidazole and placebo of H. perforatum (n=80) vaginally for 5 d. Amsel criteria were used for diagnosis and assessing cure and recurrence of BV. The comparisons was done using Chi-square, Fisher's exact and logistic regression. Results: At 10–12 d, cure rate was 82% in the H. perforatum and 85% in metronidazole group (risk ratio 0.9, 95% confidence interval 0.6 to 1.3). Among the cured women, recurrence rate was 9% in the H. perforatum and 13% in the metronidazole group at the 30–35 d visit (risk ratio 0.8, 95% confidence interval 0.4 to 1.3). There was no statistically significant difference between the groups regarding any patient complaints, except itching which was less in H. perforatum group (5% vs. 16%, P=0.018 at the first and 13% vs. 43%, P<0.001 at the second follow-up). No significant adverse event was reported at any groups. Conclusions: H. perforatum could be a good option for treatment of BV. However, further studies are needed for its public use. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 11 896 902 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hypericum Metronidazole Vaginosis Bacterial Therapy Recurrence Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Hypericum Metronidazole Vaginosis Bacterial Therapy Recurrence Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Sakineh Mohammad-Alizadeh-Charandabi Zahra Mohammadzadeh Azizeh Farshbaf-Khalili Yousef Javadzadeh Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
topic_facet |
Hypericum Metronidazole Vaginosis Bacterial Therapy Recurrence Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To compare effect of Hypericum perforatum (H. perforatum) vaginal gel with metronidazole on bacterial vaginosis (BV) in terms of initial response to treatment and preventing recurrence (primary outcomes) and also patient complaints (secondary outcomes). Methods: In this double-blind, double dummy trial, married women aged 18–49 with BV were randomized into two groups and administered 5 g of 3% H. perforatum and placebo of metronidazole (n=82), or 5 g of 0.75% metronidazole and placebo of H. perforatum (n=80) vaginally for 5 d. Amsel criteria were used for diagnosis and assessing cure and recurrence of BV. The comparisons was done using Chi-square, Fisher's exact and logistic regression. Results: At 10–12 d, cure rate was 82% in the H. perforatum and 85% in metronidazole group (risk ratio 0.9, 95% confidence interval 0.6 to 1.3). Among the cured women, recurrence rate was 9% in the H. perforatum and 13% in the metronidazole group at the 30–35 d visit (risk ratio 0.8, 95% confidence interval 0.4 to 1.3). There was no statistically significant difference between the groups regarding any patient complaints, except itching which was less in H. perforatum group (5% vs. 16%, P=0.018 at the first and 13% vs. 43%, P<0.001 at the second follow-up). No significant adverse event was reported at any groups. Conclusions: H. perforatum could be a good option for treatment of BV. However, further studies are needed for its public use. |
format |
Article in Journal/Newspaper |
author |
Sakineh Mohammad-Alizadeh-Charandabi Zahra Mohammadzadeh Azizeh Farshbaf-Khalili Yousef Javadzadeh |
author_facet |
Sakineh Mohammad-Alizadeh-Charandabi Zahra Mohammadzadeh Azizeh Farshbaf-Khalili Yousef Javadzadeh |
author_sort |
Sakineh Mohammad-Alizadeh-Charandabi |
title |
Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
title_short |
Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
title_full |
Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
title_fullStr |
Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
title_full_unstemmed |
Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
title_sort |
effect of hypericum perforatum l. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.201414B160 https://doaj.org/article/73686bdb8c054deea3b9598e6489524c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 11, Pp 896-902 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S222116911530037X https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.201414B160 https://doaj.org/article/73686bdb8c054deea3b9598e6489524c |
op_doi |
https://doi.org/10.12980/APJTB.4.201414B160 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_issue |
11 |
container_start_page |
896 |
op_container_end_page |
902 |
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1766342250714890240 |