A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters.
Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syr...
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ftdoajarticles:oai:doaj.org/article:7353edbe3113432c8b6213e9bf19ade5 2024-09-09T19:26:09+00:00 A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. Neeltje van Doremalen Teresa Lambe Sarah Sebastian Trenton Bushmaker Robert Fischer Friederike Feldmann Elaine Haddock Michael Letko Victoria A Avanzato Ilona Rissanen Rachel LaCasse Dana Scott Thomas A Bowden Sarah Gilbert Vincent Munster 2019-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007462 https://doaj.org/article/7353edbe3113432c8b6213e9bf19ade5 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007462 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007462 https://doaj.org/article/7353edbe3113432c8b6213e9bf19ade5 PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007462 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007462 2024-08-05T17:48:54Z Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted in uniform protection against a lethal challenge with NiV Bangladesh: all animals survived challenge and we were unable to find infectious virus either in oral swabs, lung or brain tissue. Furthermore, no pathological lung damage was observed. A single-dose of ChAdOx1 NiVB also prevented disease and lethality from heterologous challenge with NiV Malaysia. While we were unable to detect infectious virus in swabs or tissue of animals challenged with the heterologous strain, a very limited amount of viral RNA could be found in lung tissue by in situ hybridization. A single dose of ChAdOx1 NiVB also provided partial protection against Hendra virus and passive transfer of antibodies elicited by ChAdOx1 NiVB vaccination partially protected Syrian hamsters against NiV Bangladesh. From these data, we conclude that ChAdOx1 NiVB is a suitable candidate for further NiV vaccine pre-clinical development. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 6 e0007462 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Neeltje van Doremalen Teresa Lambe Sarah Sebastian Trenton Bushmaker Robert Fischer Friederike Feldmann Elaine Haddock Michael Letko Victoria A Avanzato Ilona Rissanen Rachel LaCasse Dana Scott Thomas A Bowden Sarah Gilbert Vincent Munster A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted in uniform protection against a lethal challenge with NiV Bangladesh: all animals survived challenge and we were unable to find infectious virus either in oral swabs, lung or brain tissue. Furthermore, no pathological lung damage was observed. A single-dose of ChAdOx1 NiVB also prevented disease and lethality from heterologous challenge with NiV Malaysia. While we were unable to detect infectious virus in swabs or tissue of animals challenged with the heterologous strain, a very limited amount of viral RNA could be found in lung tissue by in situ hybridization. A single dose of ChAdOx1 NiVB also provided partial protection against Hendra virus and passive transfer of antibodies elicited by ChAdOx1 NiVB vaccination partially protected Syrian hamsters against NiV Bangladesh. From these data, we conclude that ChAdOx1 NiVB is a suitable candidate for further NiV vaccine pre-clinical development. |
format |
Article in Journal/Newspaper |
author |
Neeltje van Doremalen Teresa Lambe Sarah Sebastian Trenton Bushmaker Robert Fischer Friederike Feldmann Elaine Haddock Michael Letko Victoria A Avanzato Ilona Rissanen Rachel LaCasse Dana Scott Thomas A Bowden Sarah Gilbert Vincent Munster |
author_facet |
Neeltje van Doremalen Teresa Lambe Sarah Sebastian Trenton Bushmaker Robert Fischer Friederike Feldmann Elaine Haddock Michael Letko Victoria A Avanzato Ilona Rissanen Rachel LaCasse Dana Scott Thomas A Bowden Sarah Gilbert Vincent Munster |
author_sort |
Neeltje van Doremalen |
title |
A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
title_short |
A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
title_full |
A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
title_fullStr |
A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
title_full_unstemmed |
A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters. |
title_sort |
single-dose chadox1-vectored vaccine provides complete protection against nipah bangladesh and malaysia in syrian golden hamsters. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007462 https://doaj.org/article/7353edbe3113432c8b6213e9bf19ade5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007462 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007462 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007462 https://doaj.org/article/7353edbe3113432c8b6213e9bf19ade5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007462 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
6 |
container_start_page |
e0007462 |
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