Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum
Three p -terphenyls ( 2 – 4 )—2-hydroxy-3,5-dimethoxy- p -terphenyl ( 2 ), 2-hydroxy-3,6-dimethoxy- p -terphenyl ( 3 ), and 2,3,5,6-tetramethoxy- p -terphenyl ( 4 )—were isolated for the first time as natural products along with seven known compounds ( 1 , 5 – 10 ) from the Antarctic lichen Stereoca...
Published in: | Molecules |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2022
|
Subjects: | |
Online Access: | https://doi.org/10.3390/molecules27072363 https://doaj.org/article/7341f2538e644b0c95b1e1c75f940644 |
Summary: | Three p -terphenyls ( 2 – 4 )—2-hydroxy-3,5-dimethoxy- p -terphenyl ( 2 ), 2-hydroxy-3,6-dimethoxy- p -terphenyl ( 3 ), and 2,3,5,6-tetramethoxy- p -terphenyl ( 4 )—were isolated for the first time as natural products along with seven known compounds ( 1 , 5 – 10 ) from the Antarctic lichen Stereocaulon alpinum. Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound 3 exhibited cytotoxicity against HCT116 cells with the IC 50 value of 3.76 ± 0.03 μM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC 50 value of 22.82 ± 0.015 μM. |
---|