Tuberculosis in renal transplant patients
Tuberculosis (TB) was diagnosed in 25 of 466 patients who underwent renal transplant over a period of 15 years. TB developed from 1 month to 9 years post-transplant. In 56% of the cases the onset was within the first post-transplant year. TB affected several isolated or combined organs. Pulmonary in...
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Universidade de São Paulo (USP)
1987
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ftdoajarticles:oai:doaj.org/article:72d1604b57fa4583bf332cbcfe80f806 2024-09-09T19:27:23+00:00 Tuberculosis in renal transplant patients Flávio Jota de Paula Luiz Sérgio Azevedo Luiz Balthazar Saldanha Luiz Estevam Ianhez Emil Sabbaga 1987-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651987000500002 https://doaj.org/article/72d1604b57fa4583bf332cbcfe80f806 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500002 https://doaj.org/article/72d1604b57fa4583bf332cbcfe80f806 Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 268-275 (1987) Tuberculosis Kidney transplantation Infection Immunosuppression Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1987 ftdoajarticles https://doi.org/10.1590/S0036-46651987000500002 2024-08-05T17:49:30Z Tuberculosis (TB) was diagnosed in 25 of 466 patients who underwent renal transplant over a period of 15 years. TB developed from 1 month to 9 years post-transplant. In 56% of the cases the onset was within the first post-transplant year. TB affected several isolated or combined organs. Pulmonary involvement was present in 76% of cases, either as isolated pleuro-pulmonary (56%) or associated with other sites (20%). The non-pulmonary sites were: skin, joints, tests, urinary tract, central nervous system and lymphonodules. The diagnosis was confirmed by biopsy in 64% of the cases, by identification of tubercle bacilli in 24% and only at necropsy in 12% Biopsy specimens could be classified in three histological forms: exudative, that occurred in early onset and more severe cases granulomatous in late onset and benign cases; and mixed in intermediate cases. Azathioprine dosages were similar along post-transplant time periods in TB patients and in the control groups; and in TB patients who were cured and who died. The number of steroid treated rejection crises was greater in TB than in the control group. Prednisone doses were higher and the number of rejection crises was greater in TB patients who died than in those who were cured. Fifteen patients were cured and ten died, two of them of causes unrelated to TB. Six of the eight TB-related deaths occurred in the first 6 post-transplant months. The outcome was poor in patients in whom TB arose early in post-transplant period and where the exudative or mixed forms were present; whereas the prognosis was good in patients with late onset and granulomatous form of TB. In one patient TB was transmitted by the allograft. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 29 5 268 275 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Tuberculosis Kidney transplantation Infection Immunosuppression Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Tuberculosis Kidney transplantation Infection Immunosuppression Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Flávio Jota de Paula Luiz Sérgio Azevedo Luiz Balthazar Saldanha Luiz Estevam Ianhez Emil Sabbaga Tuberculosis in renal transplant patients |
topic_facet |
Tuberculosis Kidney transplantation Infection Immunosuppression Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Tuberculosis (TB) was diagnosed in 25 of 466 patients who underwent renal transplant over a period of 15 years. TB developed from 1 month to 9 years post-transplant. In 56% of the cases the onset was within the first post-transplant year. TB affected several isolated or combined organs. Pulmonary involvement was present in 76% of cases, either as isolated pleuro-pulmonary (56%) or associated with other sites (20%). The non-pulmonary sites were: skin, joints, tests, urinary tract, central nervous system and lymphonodules. The diagnosis was confirmed by biopsy in 64% of the cases, by identification of tubercle bacilli in 24% and only at necropsy in 12% Biopsy specimens could be classified in three histological forms: exudative, that occurred in early onset and more severe cases granulomatous in late onset and benign cases; and mixed in intermediate cases. Azathioprine dosages were similar along post-transplant time periods in TB patients and in the control groups; and in TB patients who were cured and who died. The number of steroid treated rejection crises was greater in TB than in the control group. Prednisone doses were higher and the number of rejection crises was greater in TB patients who died than in those who were cured. Fifteen patients were cured and ten died, two of them of causes unrelated to TB. Six of the eight TB-related deaths occurred in the first 6 post-transplant months. The outcome was poor in patients in whom TB arose early in post-transplant period and where the exudative or mixed forms were present; whereas the prognosis was good in patients with late onset and granulomatous form of TB. In one patient TB was transmitted by the allograft. |
format |
Article in Journal/Newspaper |
author |
Flávio Jota de Paula Luiz Sérgio Azevedo Luiz Balthazar Saldanha Luiz Estevam Ianhez Emil Sabbaga |
author_facet |
Flávio Jota de Paula Luiz Sérgio Azevedo Luiz Balthazar Saldanha Luiz Estevam Ianhez Emil Sabbaga |
author_sort |
Flávio Jota de Paula |
title |
Tuberculosis in renal transplant patients |
title_short |
Tuberculosis in renal transplant patients |
title_full |
Tuberculosis in renal transplant patients |
title_fullStr |
Tuberculosis in renal transplant patients |
title_full_unstemmed |
Tuberculosis in renal transplant patients |
title_sort |
tuberculosis in renal transplant patients |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1987 |
url |
https://doi.org/10.1590/S0036-46651987000500002 https://doaj.org/article/72d1604b57fa4583bf332cbcfe80f806 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 268-275 (1987) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500002&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500002 https://doaj.org/article/72d1604b57fa4583bf332cbcfe80f806 |
op_doi |
https://doi.org/10.1590/S0036-46651987000500002 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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29 |
container_issue |
5 |
container_start_page |
268 |
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