Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study
Abstract Background In sub-Saharan Africa, the distributions of malaria and HIV widely overlap. Among pregnant and non-pregnant adults, HIV affects susceptibility to malaria, its clinical course and impairs antibody responses to malaria antigens. However, the relationship between the two diseases in...
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ftdoajarticles:oai:doaj.org/article:72aa0184c83b4f32be29e395d038fbed 2023-05-15T15:16:30+02:00 Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study Kinyanjui Samson M Ndungu Francis M Muema Daniel KM Berkley James A 2011-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-55 https://doaj.org/article/72aa0184c83b4f32be29e395d038fbed EN eng BMC http://www.malariajournal.com/content/10/1/55 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-55 1475-2875 https://doaj.org/article/72aa0184c83b4f32be29e395d038fbed Malaria Journal, Vol 10, Iss 1, p 55 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-55 2022-12-31T01:37:29Z Abstract Background In sub-Saharan Africa, the distributions of malaria and HIV widely overlap. Among pregnant and non-pregnant adults, HIV affects susceptibility to malaria, its clinical course and impairs antibody responses to malaria antigens. However, the relationship between the two diseases in childhood, when most deaths from malaria occur, is less clear. It was previously reported that HIV is associated with admission to hospital in rural Kenya with severe malaria among children, except in infancy. HIV-infected children with severe malaria were older, had higher parasite density and increased mortality, raising a hypothesis that HIV interferes with naturally acquired immunity to malaria, hence with little effect at younger ages (a shorter history of exposure). To test this hypothesis, levels of anti-merozoite and schizont extract antibodies were compared between HIV-infected and uninfected children who participated in the original study. Methods IgG responses to malaria antigens that are potential targets for immunity to malaria (AMA1, MSP2, MSP3 and schizont extract) were compared between 115 HIV-infected and 115 age-matched, HIV-uninfected children who presented with severe malaria. The children were classified as high and low responders for each antigen and assigned antibody-response breadth scores according to the number of antigens to which they were responsive. A predictive logistic regression model was used to test if HIV was an effect modifier on the age-related acquisition of antibody responses, with age as a continuous variable. Results Point estimates of the responses to all antigens were lower amongst HIV-infected children, but this was only statistically significant for AMA1 (P = 0.028). HIV-infected children were less likely to be high responders to AMA1 [OR 0.44 (95%CI, 0.2-0.90) P = 0.024]. HIV was associated with a reduced breadth of responses to individual merozoite antigens (P = 0.02). HIV strongly modified the acquisition of antibodies against schizont extract with increasing age (P ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 55 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kinyanjui Samson M Ndungu Francis M Muema Daniel KM Berkley James A Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In sub-Saharan Africa, the distributions of malaria and HIV widely overlap. Among pregnant and non-pregnant adults, HIV affects susceptibility to malaria, its clinical course and impairs antibody responses to malaria antigens. However, the relationship between the two diseases in childhood, when most deaths from malaria occur, is less clear. It was previously reported that HIV is associated with admission to hospital in rural Kenya with severe malaria among children, except in infancy. HIV-infected children with severe malaria were older, had higher parasite density and increased mortality, raising a hypothesis that HIV interferes with naturally acquired immunity to malaria, hence with little effect at younger ages (a shorter history of exposure). To test this hypothesis, levels of anti-merozoite and schizont extract antibodies were compared between HIV-infected and uninfected children who participated in the original study. Methods IgG responses to malaria antigens that are potential targets for immunity to malaria (AMA1, MSP2, MSP3 and schizont extract) were compared between 115 HIV-infected and 115 age-matched, HIV-uninfected children who presented with severe malaria. The children were classified as high and low responders for each antigen and assigned antibody-response breadth scores according to the number of antigens to which they were responsive. A predictive logistic regression model was used to test if HIV was an effect modifier on the age-related acquisition of antibody responses, with age as a continuous variable. Results Point estimates of the responses to all antigens were lower amongst HIV-infected children, but this was only statistically significant for AMA1 (P = 0.028). HIV-infected children were less likely to be high responders to AMA1 [OR 0.44 (95%CI, 0.2-0.90) P = 0.024]. HIV was associated with a reduced breadth of responses to individual merozoite antigens (P = 0.02). HIV strongly modified the acquisition of antibodies against schizont extract with increasing age (P ... |
format |
Article in Journal/Newspaper |
author |
Kinyanjui Samson M Ndungu Francis M Muema Daniel KM Berkley James A |
author_facet |
Kinyanjui Samson M Ndungu Francis M Muema Daniel KM Berkley James A |
author_sort |
Kinyanjui Samson M |
title |
Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
title_short |
Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
title_full |
Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
title_fullStr |
Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
title_full_unstemmed |
Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study |
title_sort |
effect of hiv infection on the acute antibody response to malaria antigens in children: an observational study |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-55 https://doaj.org/article/72aa0184c83b4f32be29e395d038fbed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 55 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/55 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-55 1475-2875 https://doaj.org/article/72aa0184c83b4f32be29e395d038fbed |
op_doi |
https://doi.org/10.1186/1475-2875-10-55 |
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Malaria Journal |
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10 |
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1 |
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55 |
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1766346806225010688 |