A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
Background Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases. Methodology and principle findings This study...
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ftdoajarticles:oai:doaj.org/article:723c561424fa4c169c134e5e8730f412 2023-05-15T15:10:34+02:00 A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009685 https://doaj.org/article/723c561424fa4c169c134e5e8730f412 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009685 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009685 https://doaj.org/article/723c561424fa4c169c134e5e8730f412 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009685 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009685 2022-12-31T07:09:49Z Background Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases. Methodology and principle findings This study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed. Approximately 17% of patients were positive for either ST (1,337/8,150 patients tested) or MT (1,283/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis. Conclusions The data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 8 e0009685 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Scrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases. Methodology and principle findings This study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed. Approximately 17% of patients were positive for either ST (1,337/8,150 patients tested) or MT (1,283/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis. Conclusions The data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase. |
format |
Article in Journal/Newspaper |
author |
Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton |
author_facet |
Tamalee Roberts Daniel M Parker Philip L Bulterys Sayaphet Rattanavong Ivo Elliott Koukeo Phommasone Mayfong Mayxay Vilada Chansamouth Matthew T Robinson Stuart D Blacksell Paul N Newton |
author_sort |
Tamalee Roberts |
title |
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
title_short |
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
title_full |
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
title_fullStr |
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
title_full_unstemmed |
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate. |
title_sort |
spatio-temporal analysis of scrub typhus and murine typhus in laos; implications from changing landscapes and climate. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009685 https://doaj.org/article/723c561424fa4c169c134e5e8730f412 |
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Arctic |
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Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009685 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009685 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009685 https://doaj.org/article/723c561424fa4c169c134e5e8730f412 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009685 |
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PLOS Neglected Tropical Diseases |
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15 |
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8 |
container_start_page |
e0009685 |
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