Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya
Abstract Background Understanding the genetic structure of island Anopheles gambiae populations is important for the current tactics in mosquito control and for the proposed strategy using genetically-modified mosquitoes (GMM). Genetically-isolated mosquito populations on islands are a potential sit...
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ftdoajarticles:oai:doaj.org/article:7233c1cc55ab48109f2f1988c2ec9021 2023-05-15T15:13:14+02:00 Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya Beier John Minakawa Noboru Chen Hong Yan Guiyun 2004-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-3-48 https://doaj.org/article/7233c1cc55ab48109f2f1988c2ec9021 EN eng BMC http://www.malariajournal.com/content/3/1/48 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-3-48 1475-2875 https://doaj.org/article/7233c1cc55ab48109f2f1988c2ec9021 Malaria Journal, Vol 3, Iss 1, p 48 (2004) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2004 ftdoajarticles https://doi.org/10.1186/1475-2875-3-48 2022-12-31T08:10:45Z Abstract Background Understanding the genetic structure of island Anopheles gambiae populations is important for the current tactics in mosquito control and for the proposed strategy using genetically-modified mosquitoes (GMM). Genetically-isolated mosquito populations on islands are a potential site for testing GMM. The objective of this study was to determine the genetic structure of A. gambiae populations on the islands in Lake Victoria, western Kenya. Methods The genetic diversity and the population genetic structures of 13 A. gambiae populations from five islands on Lake Victoria and six villages from the surrounding mainland area in the Suba District were examined using six microsatellite markers. The distance range of sampling sites varied between 2.5 and 35.1 km. Results A similar level of genetic diversity between island mosquito populations and adjacent mainland populations was found. The average number of alleles per locus was 7.3 for the island populations and 6.8 for the mainland populations. The average observed heterozygosity was 0.32 and 0.28 for the island and mainland populations, respectively. A low but statistically significant genetic structure was detected among the island populations (F ST = 0.019) and between the island and mainland populations (F ST = 0.003). A total of 12 private alleles were found, and nine of them were from the island populations. Conclusion A level of genetic differentiation between the island and mainland populations was found. Large extent of gene flow between the island and mainland mosquito populations may result from wind- or human-assisted dispersal. Should the islands on Lake Victoria be used as a trial site for the release program of GMM, mosquito dispersal between the islands and between the island and the mainland should be vigorously monitored. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Five Islands ENVELOPE(-69.415,-69.415,60.184,60.184) Malaria Journal 3 1 48 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Beier John Minakawa Noboru Chen Hong Yan Guiyun Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Understanding the genetic structure of island Anopheles gambiae populations is important for the current tactics in mosquito control and for the proposed strategy using genetically-modified mosquitoes (GMM). Genetically-isolated mosquito populations on islands are a potential site for testing GMM. The objective of this study was to determine the genetic structure of A. gambiae populations on the islands in Lake Victoria, western Kenya. Methods The genetic diversity and the population genetic structures of 13 A. gambiae populations from five islands on Lake Victoria and six villages from the surrounding mainland area in the Suba District were examined using six microsatellite markers. The distance range of sampling sites varied between 2.5 and 35.1 km. Results A similar level of genetic diversity between island mosquito populations and adjacent mainland populations was found. The average number of alleles per locus was 7.3 for the island populations and 6.8 for the mainland populations. The average observed heterozygosity was 0.32 and 0.28 for the island and mainland populations, respectively. A low but statistically significant genetic structure was detected among the island populations (F ST = 0.019) and between the island and mainland populations (F ST = 0.003). A total of 12 private alleles were found, and nine of them were from the island populations. Conclusion A level of genetic differentiation between the island and mainland populations was found. Large extent of gene flow between the island and mainland mosquito populations may result from wind- or human-assisted dispersal. Should the islands on Lake Victoria be used as a trial site for the release program of GMM, mosquito dispersal between the islands and between the island and the mainland should be vigorously monitored. |
format |
Article in Journal/Newspaper |
author |
Beier John Minakawa Noboru Chen Hong Yan Guiyun |
author_facet |
Beier John Minakawa Noboru Chen Hong Yan Guiyun |
author_sort |
Beier John |
title |
Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
title_short |
Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
title_full |
Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
title_fullStr |
Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
title_full_unstemmed |
Population genetic structure of Anopheles gambiae mosquitoes on Lake Victoria islands, west Kenya |
title_sort |
population genetic structure of anopheles gambiae mosquitoes on lake victoria islands, west kenya |
publisher |
BMC |
publishDate |
2004 |
url |
https://doi.org/10.1186/1475-2875-3-48 https://doaj.org/article/7233c1cc55ab48109f2f1988c2ec9021 |
long_lat |
ENVELOPE(-69.415,-69.415,60.184,60.184) |
geographic |
Arctic Five Islands |
geographic_facet |
Arctic Five Islands |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 3, Iss 1, p 48 (2004) |
op_relation |
http://www.malariajournal.com/content/3/1/48 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-3-48 1475-2875 https://doaj.org/article/7233c1cc55ab48109f2f1988c2ec9021 |
op_doi |
https://doi.org/10.1186/1475-2875-3-48 |
container_title |
Malaria Journal |
container_volume |
3 |
container_issue |
1 |
container_start_page |
48 |
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1766343819599544320 |