Chinese expert consensus on early prevention and intervention of sepsis
Sepsis is currently a major problem and challenge facing the medical community. With rapid development and progress of modern medicine, researchers have put more and more attention on sepsis; meanwhile, the morbidity and mortality of sepsis remains high despite great efforts from experts in various...
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ftdoajarticles:oai:doaj.org/article:71f0a8b0a85b40a7a468906ffedb08d9 2023-05-15T15:15:26+02:00 Chinese expert consensus on early prevention and intervention of sepsis Zhong Wang Xuezhong Yu Yuguo Chen Chuanzhu Lv Xiaodong Zhao 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.289438 https://doaj.org/article/71f0a8b0a85b40a7a468906ffedb08d9 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=8;spage=335;epage=349;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.289438 https://doaj.org/article/71f0a8b0a85b40a7a468906ffedb08d9 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 8, Pp 335-349 (2020) sepsis preventing infection cytokines organ function Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.289438 2022-12-31T00:06:13Z Sepsis is currently a major problem and challenge facing the medical community. With rapid development and progress of modern medicine, researchers have put more and more attention on sepsis; meanwhile, the morbidity and mortality of sepsis remains high despite great efforts from experts in various fields. According to updated guidelines, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Infection is the initial step of sepsis progression, and development from infection to sepsis is a complex pathophysiological process, including pathogen invasion, cytokine release, capillary leakage, microcirculation dysfunction, etc. which finally leads to organ metabolic disorders and functional failure. According to the latest recommended international guidelines of Sepsis 3.0, the presence of infection and SOFA score ≥ 2 are considered as the diagnostic criteria for sepsis, and the “rescue” measures mainly focus on reversal of organ dysfunction. However, despite nearly two decades of efforts, the “Save Sepsis Campaign” has not achieved satisfactory results. Emergency medicine is the frontier subject of acute and severe illness which treats patients with acute infections at the earliest. If at this stage, physicians can predict the possibility of sepsis progression from demographic characteristics, localize the pathogen and infection, detect the inflammatory storms by tests of cytokines and evaluate the severity of the infection with more effective clinical scoring system, and then take effective measures to prevent infection from developing into sepsis in high-risk patients, the morbidity and mortality of sepsis in patients with acute infection will be greatly reduced. Based on this situation, Chinese emergency medicine experts proposed the concept of “preventing and blocking” sepsis, and launched the nationwide “Preventing Sepsis Campaign in China (PSCC)” nationwide. The main concept is summarized as “three early and two reduces” which includes early detection, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 8 335 |
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English |
topic |
sepsis preventing infection cytokines organ function Arctic medicine. Tropical medicine RC955-962 |
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sepsis preventing infection cytokines organ function Arctic medicine. Tropical medicine RC955-962 Zhong Wang Xuezhong Yu Yuguo Chen Chuanzhu Lv Xiaodong Zhao Chinese expert consensus on early prevention and intervention of sepsis |
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sepsis preventing infection cytokines organ function Arctic medicine. Tropical medicine RC955-962 |
description |
Sepsis is currently a major problem and challenge facing the medical community. With rapid development and progress of modern medicine, researchers have put more and more attention on sepsis; meanwhile, the morbidity and mortality of sepsis remains high despite great efforts from experts in various fields. According to updated guidelines, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Infection is the initial step of sepsis progression, and development from infection to sepsis is a complex pathophysiological process, including pathogen invasion, cytokine release, capillary leakage, microcirculation dysfunction, etc. which finally leads to organ metabolic disorders and functional failure. According to the latest recommended international guidelines of Sepsis 3.0, the presence of infection and SOFA score ≥ 2 are considered as the diagnostic criteria for sepsis, and the “rescue” measures mainly focus on reversal of organ dysfunction. However, despite nearly two decades of efforts, the “Save Sepsis Campaign” has not achieved satisfactory results. Emergency medicine is the frontier subject of acute and severe illness which treats patients with acute infections at the earliest. If at this stage, physicians can predict the possibility of sepsis progression from demographic characteristics, localize the pathogen and infection, detect the inflammatory storms by tests of cytokines and evaluate the severity of the infection with more effective clinical scoring system, and then take effective measures to prevent infection from developing into sepsis in high-risk patients, the morbidity and mortality of sepsis in patients with acute infection will be greatly reduced. Based on this situation, Chinese emergency medicine experts proposed the concept of “preventing and blocking” sepsis, and launched the nationwide “Preventing Sepsis Campaign in China (PSCC)” nationwide. The main concept is summarized as “three early and two reduces” which includes early detection, ... |
format |
Article in Journal/Newspaper |
author |
Zhong Wang Xuezhong Yu Yuguo Chen Chuanzhu Lv Xiaodong Zhao |
author_facet |
Zhong Wang Xuezhong Yu Yuguo Chen Chuanzhu Lv Xiaodong Zhao |
author_sort |
Zhong Wang |
title |
Chinese expert consensus on early prevention and intervention of sepsis |
title_short |
Chinese expert consensus on early prevention and intervention of sepsis |
title_full |
Chinese expert consensus on early prevention and intervention of sepsis |
title_fullStr |
Chinese expert consensus on early prevention and intervention of sepsis |
title_full_unstemmed |
Chinese expert consensus on early prevention and intervention of sepsis |
title_sort |
chinese expert consensus on early prevention and intervention of sepsis |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.289438 https://doaj.org/article/71f0a8b0a85b40a7a468906ffedb08d9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 8, Pp 335-349 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=8;spage=335;epage=349;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.289438 https://doaj.org/article/71f0a8b0a85b40a7a468906ffedb08d9 |
op_doi |
https://doi.org/10.4103/1995-7645.289438 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
8 |
container_start_page |
335 |
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