Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight
Abstract Background Infection with Plasmodium falciparum during pregnancy contributes substantially to the disease burden in both mothers and offspring. Placental malaria may lead to intrauterine growth restriction or preterm delivery resulting in low birth weight (LBW), which, in general, is associ...
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ftdoajarticles:oai:doaj.org/article:71b858d975c34c7fa5272b15677933d4 2023-05-15T15:14:57+02:00 Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight Palmero Melba S Waight Pauline Crozier Sarah Miles David JC Walther Brigitte Ojuola Olubukola Touray Ebrima Sande Marianne Whittle Hilton Rowland-Jones Sarah Flanagan Katie L 2010-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-16 https://doaj.org/article/71b858d975c34c7fa5272b15677933d4 EN eng BMC http://www.malariajournal.com/content/9/1/16 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-16 1475-2875 https://doaj.org/article/71b858d975c34c7fa5272b15677933d4 Malaria Journal, Vol 9, Iss 1, p 16 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-16 2022-12-31T08:12:21Z Abstract Background Infection with Plasmodium falciparum during pregnancy contributes substantially to the disease burden in both mothers and offspring. Placental malaria may lead to intrauterine growth restriction or preterm delivery resulting in low birth weight (LBW), which, in general, is associated with increased infant morbidity and mortality. However, little is known about the possible direct impact of the specific disease processes occurring in PM on longer term outcomes such as subsequent retarded growth development independent of LBW. Methods In an existing West-African cohort, 783 healthy infants with a birth weight of at least 2,000 g were followed up during their first year of life. The aim of the study was to investigate if Plasmodium falciparum infection of the placenta, assessed by placental histology, has an impact on several anthropometric parameters, measured at birth and after three, six and 12 months using generalized estimating equations models adjusting for moderate low birth weight. Results Independent of LBW, first to third born infants who were exposed to either past, chronic or acute placental malaria during pregnancy had significantly lower weight-for-age (-0.43, 95% CI: -0.80;-0.07), weight-for-length (-0.47, 95% CI: -0.84; -0.10) and BMI-for-age z-scores (-0.57, 95% CI: -0.84; -0.10) compared to infants born to mothers who were not diagnosed with placental malaria (p = 0.019, 0.013, and 0.012, respectively). Interestingly, the longitudinal data on histology-based diagnosis of PM also document a sharp decline of PM prevalence in the Sukuta cohort from 16.5% in 2002 to 5.4% in 2004. Conclusions It was demonstrated that PM has a negative impact on the infant's subsequent weight development that is independent of LBW, suggesting that the longer term effects of PM have been underestimated, even in areas where malaria transmission is declining. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Palmero Melba S Waight Pauline Crozier Sarah Miles David JC Walther Brigitte Ojuola Olubukola Touray Ebrima Sande Marianne Whittle Hilton Rowland-Jones Sarah Flanagan Katie L Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Infection with Plasmodium falciparum during pregnancy contributes substantially to the disease burden in both mothers and offspring. Placental malaria may lead to intrauterine growth restriction or preterm delivery resulting in low birth weight (LBW), which, in general, is associated with increased infant morbidity and mortality. However, little is known about the possible direct impact of the specific disease processes occurring in PM on longer term outcomes such as subsequent retarded growth development independent of LBW. Methods In an existing West-African cohort, 783 healthy infants with a birth weight of at least 2,000 g were followed up during their first year of life. The aim of the study was to investigate if Plasmodium falciparum infection of the placenta, assessed by placental histology, has an impact on several anthropometric parameters, measured at birth and after three, six and 12 months using generalized estimating equations models adjusting for moderate low birth weight. Results Independent of LBW, first to third born infants who were exposed to either past, chronic or acute placental malaria during pregnancy had significantly lower weight-for-age (-0.43, 95% CI: -0.80;-0.07), weight-for-length (-0.47, 95% CI: -0.84; -0.10) and BMI-for-age z-scores (-0.57, 95% CI: -0.84; -0.10) compared to infants born to mothers who were not diagnosed with placental malaria (p = 0.019, 0.013, and 0.012, respectively). Interestingly, the longitudinal data on histology-based diagnosis of PM also document a sharp decline of PM prevalence in the Sukuta cohort from 16.5% in 2002 to 5.4% in 2004. Conclusions It was demonstrated that PM has a negative impact on the infant's subsequent weight development that is independent of LBW, suggesting that the longer term effects of PM have been underestimated, even in areas where malaria transmission is declining. |
format |
Article in Journal/Newspaper |
author |
Palmero Melba S Waight Pauline Crozier Sarah Miles David JC Walther Brigitte Ojuola Olubukola Touray Ebrima Sande Marianne Whittle Hilton Rowland-Jones Sarah Flanagan Katie L |
author_facet |
Palmero Melba S Waight Pauline Crozier Sarah Miles David JC Walther Brigitte Ojuola Olubukola Touray Ebrima Sande Marianne Whittle Hilton Rowland-Jones Sarah Flanagan Katie L |
author_sort |
Palmero Melba S |
title |
Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
title_short |
Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
title_full |
Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
title_fullStr |
Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
title_full_unstemmed |
Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight |
title_sort |
placental malaria is associated with reduced early life weight development of affected children independent of low birth weight |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-16 https://doaj.org/article/71b858d975c34c7fa5272b15677933d4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 16 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/16 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-16 1475-2875 https://doaj.org/article/71b858d975c34c7fa5272b15677933d4 |
op_doi |
https://doi.org/10.1186/1475-2875-9-16 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
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1766345341596073984 |