Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes.
Hyperglycemia is correlated with worse in-hospital outcomes in acute infectious diseases such as coronavirus disease 2019 (COVID-19) and severe fever with thrombocytopenia syndrome (SFTS). This study assessed the relationship between fasting plasma glucose (FPG) levels and in-hospital mortality, dis...
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ftdoajarticles:oai:doaj.org/article:7173a57bac7f46f1a3544af6066177fb 2024-09-09T19:27:03+00:00 Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. Jun Pan Zhihao Yang Wen Xu Shan Tian Xiaobo Liu Chunxia Guo 2024-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0012125 https://doaj.org/article/7173a57bac7f46f1a3544af6066177fb EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012125&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012125 https://doaj.org/article/7173a57bac7f46f1a3544af6066177fb PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0012125 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0012125 2024-08-05T17:49:27Z Hyperglycemia is correlated with worse in-hospital outcomes in acute infectious diseases such as coronavirus disease 2019 (COVID-19) and severe fever with thrombocytopenia syndrome (SFTS). This study assessed the relationship between fasting plasma glucose (FPG) levels and in-hospital mortality, disease type, and secondary infections among individuals with SFTS without preexisting diabetes. The clinical data and laboratory results upon admission of 560 patients with SFTS without preexisting diabetes meeting the inclusion criteria at Wuhan Union Hospital were collected. FPG levels in surviving patients with SFTS subjects were significantly lower than those in patients with SFTS who had died (P<0.0001). In multivariate Cox regression, high FPG level (≥11.1 mmol/L) was a risk factor independently associated with the in-hospital death of patients with SFTS without preexisting diabetes. Similarly, the FPG levels in general patients with SFTS were significantly lower than those in patients with severe SFTS (P<0.0001). Multivariate logistic regression identified high FPG level (7.0-11.1 mmol/L) as a risk factor independently associated with SFTS severity. While FPG levels were comparable between patients with SFTS with and without secondary infection (P = 0.5521), logistic regression analysis revealed that high FPG levels were not a risk factor for secondary infection in patients with SFTS without preexisting diabetes. High FPG level on admission was an independent predictor of in-hospital death and severe disease in individuals with SFTS without preexisting diabetes. FPG screening upon admission and glycemic control are effective methods for improving the prognosis of patients with SFTS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 18 4 e0012125 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jun Pan Zhihao Yang Wen Xu Shan Tian Xiaobo Liu Chunxia Guo Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Hyperglycemia is correlated with worse in-hospital outcomes in acute infectious diseases such as coronavirus disease 2019 (COVID-19) and severe fever with thrombocytopenia syndrome (SFTS). This study assessed the relationship between fasting plasma glucose (FPG) levels and in-hospital mortality, disease type, and secondary infections among individuals with SFTS without preexisting diabetes. The clinical data and laboratory results upon admission of 560 patients with SFTS without preexisting diabetes meeting the inclusion criteria at Wuhan Union Hospital were collected. FPG levels in surviving patients with SFTS subjects were significantly lower than those in patients with SFTS who had died (P<0.0001). In multivariate Cox regression, high FPG level (≥11.1 mmol/L) was a risk factor independently associated with the in-hospital death of patients with SFTS without preexisting diabetes. Similarly, the FPG levels in general patients with SFTS were significantly lower than those in patients with severe SFTS (P<0.0001). Multivariate logistic regression identified high FPG level (7.0-11.1 mmol/L) as a risk factor independently associated with SFTS severity. While FPG levels were comparable between patients with SFTS with and without secondary infection (P = 0.5521), logistic regression analysis revealed that high FPG levels were not a risk factor for secondary infection in patients with SFTS without preexisting diabetes. High FPG level on admission was an independent predictor of in-hospital death and severe disease in individuals with SFTS without preexisting diabetes. FPG screening upon admission and glycemic control are effective methods for improving the prognosis of patients with SFTS. |
format |
Article in Journal/Newspaper |
author |
Jun Pan Zhihao Yang Wen Xu Shan Tian Xiaobo Liu Chunxia Guo |
author_facet |
Jun Pan Zhihao Yang Wen Xu Shan Tian Xiaobo Liu Chunxia Guo |
author_sort |
Jun Pan |
title |
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
title_short |
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
title_full |
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
title_fullStr |
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
title_full_unstemmed |
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
title_sort |
effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0012125 https://doaj.org/article/7173a57bac7f46f1a3544af6066177fb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0012125 (2024) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012125&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012125 https://doaj.org/article/7173a57bac7f46f1a3544af6066177fb |
op_doi |
https://doi.org/10.1371/journal.pntd.0012125 |
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PLOS Neglected Tropical Diseases |
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18 |
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4 |
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e0012125 |
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