A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection.
Wolbachia are alpha-proteobacteria known to infect arthropods, which are of interest for disease control since they have been associated with improved resistance to viral infection. Although several genomes for different strains have been sequenced, there is little knowledge regarding the relationsh...
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ftdoajarticles:oai:doaj.org/article:71188ce1086c431ab57334c5be76f128 2023-05-15T15:08:35+02:00 A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. Natalia E Jiménez Ziomara P Gerdtzen Álvaro Olivera-Nappa J Cristian Salgado Carlos Conca 2019-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007678 https://doaj.org/article/71188ce1086c431ab57334c5be76f128 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007678 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007678 https://doaj.org/article/71188ce1086c431ab57334c5be76f128 PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007678 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007678 2022-12-31T07:51:21Z Wolbachia are alpha-proteobacteria known to infect arthropods, which are of interest for disease control since they have been associated with improved resistance to viral infection. Although several genomes for different strains have been sequenced, there is little knowledge regarding the relationship between this bacterium and their hosts, particularly on their dependency for survival. Motivated by the potential applications on disease control, we developed genome-scale models of four Wolbachia strains known to infect arthropods: wAlbB (Aedes albopictus), wVitA (Nasonia vitripennis), wMel and wMelPop (Drosophila melanogaster). The obtained metabolic reconstructions exhibit a metabolism relying mainly on amino acids for energy production and biomass synthesis. A gap analysis was performed to detect metabolic candidates which could explain the endosymbiotic nature of this bacterium, finding that amino acids, requirements for ubiquinone precursors and provisioning of metabolites such as riboflavin could play a crucial role in this relationship. This work provides a systems biology perspective for studying the relationship of Wolbachia with its host and the development of new approaches for control of the spread of arboviral diseases. This approach, where metabolic gaps are key objects of study instead of just additions to complete a model, could be applied to other endosymbiotic bacteria of interest. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 8 e0007678 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Natalia E Jiménez Ziomara P Gerdtzen Álvaro Olivera-Nappa J Cristian Salgado Carlos Conca A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Wolbachia are alpha-proteobacteria known to infect arthropods, which are of interest for disease control since they have been associated with improved resistance to viral infection. Although several genomes for different strains have been sequenced, there is little knowledge regarding the relationship between this bacterium and their hosts, particularly on their dependency for survival. Motivated by the potential applications on disease control, we developed genome-scale models of four Wolbachia strains known to infect arthropods: wAlbB (Aedes albopictus), wVitA (Nasonia vitripennis), wMel and wMelPop (Drosophila melanogaster). The obtained metabolic reconstructions exhibit a metabolism relying mainly on amino acids for energy production and biomass synthesis. A gap analysis was performed to detect metabolic candidates which could explain the endosymbiotic nature of this bacterium, finding that amino acids, requirements for ubiquinone precursors and provisioning of metabolites such as riboflavin could play a crucial role in this relationship. This work provides a systems biology perspective for studying the relationship of Wolbachia with its host and the development of new approaches for control of the spread of arboviral diseases. This approach, where metabolic gaps are key objects of study instead of just additions to complete a model, could be applied to other endosymbiotic bacteria of interest. |
format |
Article in Journal/Newspaper |
author |
Natalia E Jiménez Ziomara P Gerdtzen Álvaro Olivera-Nappa J Cristian Salgado Carlos Conca |
author_facet |
Natalia E Jiménez Ziomara P Gerdtzen Álvaro Olivera-Nappa J Cristian Salgado Carlos Conca |
author_sort |
Natalia E Jiménez |
title |
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
title_short |
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
title_full |
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
title_fullStr |
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
title_full_unstemmed |
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
title_sort |
systems biology approach for studying wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007678 https://doaj.org/article/71188ce1086c431ab57334c5be76f128 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007678 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007678 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007678 https://doaj.org/article/71188ce1086c431ab57334c5be76f128 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007678 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
8 |
container_start_page |
e0007678 |
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1766339920984539136 |