Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature
Background: Environmental toxicants such as methylmercury, polychlorinated biphenyls, and organochlorine pesticides are potentially harmful pollutants present in contaminated food, soil, air, and water. Exposure to these ecologically relevant toxicants is prominent in Northern Canadian populations....
Published in: | International Journal of Environmental Research and Public Health |
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ftdoajarticles:oai:doaj.org/article:71056fcb0e0741b0af01aa032ea94456 2023-05-15T15:10:16+02:00 Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature Claire Fong-McMaster Sandra Konji Amanda Nitschke Anne TM Konkle 2020-02-01T00:00:00Z https://doi.org/10.3390/ijerph17030926 https://doaj.org/article/71056fcb0e0741b0af01aa032ea94456 EN eng MDPI AG https://www.mdpi.com/1660-4601/17/3/926 https://doaj.org/toc/1660-4601 1660-4601 doi:10.3390/ijerph17030926 https://doaj.org/article/71056fcb0e0741b0af01aa032ea94456 International Journal of Environmental Research and Public Health, Vol 17, Iss 3, p 926 (2020) maternal behaviour maternal brain pregnancy postpartum methylmercury polychlorinated biphenyls organochlorine pesticides persistent organic pollutants Medicine R article 2020 ftdoajarticles https://doi.org/10.3390/ijerph17030926 2022-12-31T08:58:22Z Background: Environmental toxicants such as methylmercury, polychlorinated biphenyls, and organochlorine pesticides are potentially harmful pollutants present in contaminated food, soil, air, and water. Exposure to these ecologically relevant toxicants is prominent in Northern Canadian populations. Previous work focused on toxicant exposure during pregnancy as a threat to fetal neurodevelopment. However, little is known about the individual and combined effects of these toxicants on maternal health during pregnancy and post-partum. Methods: A scoping review was conducted to synthesize the current knowledge regarding individual and combined effects of methylmercury, polychlorinated biphenyls, and organochlorine pesticides on maternal behaviour and the maternal brain. Relevant studies were identified through the PubMed, Embase, and Toxline databases. Literature involving animal models and one human cohort were included in the review. Results: Research findings indicate that exposures to these environmental toxicants are associated with neurochemical changes in rodent models. Animal models provided the majority of information on toxicant-induced alterations in maternal care behaviours. Molecular and hormonal changes hypothesized to underlie these alterations were also addressed, although studies assessing toxicant co-exposure were limited. Conclusion: This review speaks to the limited knowledge regarding effects of these persistent organic pollutants on the maternal brain and related behavioural outcomes. Further research is required to better comprehend any such effects on maternal brain and behaviour, as maternal care is an important contributor to offspring neurodevelopment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic International Journal of Environmental Research and Public Health 17 3 926 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
maternal behaviour maternal brain pregnancy postpartum methylmercury polychlorinated biphenyls organochlorine pesticides persistent organic pollutants Medicine R |
spellingShingle |
maternal behaviour maternal brain pregnancy postpartum methylmercury polychlorinated biphenyls organochlorine pesticides persistent organic pollutants Medicine R Claire Fong-McMaster Sandra Konji Amanda Nitschke Anne TM Konkle Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
topic_facet |
maternal behaviour maternal brain pregnancy postpartum methylmercury polychlorinated biphenyls organochlorine pesticides persistent organic pollutants Medicine R |
description |
Background: Environmental toxicants such as methylmercury, polychlorinated biphenyls, and organochlorine pesticides are potentially harmful pollutants present in contaminated food, soil, air, and water. Exposure to these ecologically relevant toxicants is prominent in Northern Canadian populations. Previous work focused on toxicant exposure during pregnancy as a threat to fetal neurodevelopment. However, little is known about the individual and combined effects of these toxicants on maternal health during pregnancy and post-partum. Methods: A scoping review was conducted to synthesize the current knowledge regarding individual and combined effects of methylmercury, polychlorinated biphenyls, and organochlorine pesticides on maternal behaviour and the maternal brain. Relevant studies were identified through the PubMed, Embase, and Toxline databases. Literature involving animal models and one human cohort were included in the review. Results: Research findings indicate that exposures to these environmental toxicants are associated with neurochemical changes in rodent models. Animal models provided the majority of information on toxicant-induced alterations in maternal care behaviours. Molecular and hormonal changes hypothesized to underlie these alterations were also addressed, although studies assessing toxicant co-exposure were limited. Conclusion: This review speaks to the limited knowledge regarding effects of these persistent organic pollutants on the maternal brain and related behavioural outcomes. Further research is required to better comprehend any such effects on maternal brain and behaviour, as maternal care is an important contributor to offspring neurodevelopment. |
format |
Article in Journal/Newspaper |
author |
Claire Fong-McMaster Sandra Konji Amanda Nitschke Anne TM Konkle |
author_facet |
Claire Fong-McMaster Sandra Konji Amanda Nitschke Anne TM Konkle |
author_sort |
Claire Fong-McMaster |
title |
Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
title_short |
Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
title_full |
Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
title_fullStr |
Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
title_full_unstemmed |
Canadian Arctic Contaminants and Their Effects on the Maternal Brain and Behaviour: A Scoping Review of the Animal Literature |
title_sort |
canadian arctic contaminants and their effects on the maternal brain and behaviour: a scoping review of the animal literature |
publisher |
MDPI AG |
publishDate |
2020 |
url |
https://doi.org/10.3390/ijerph17030926 https://doaj.org/article/71056fcb0e0741b0af01aa032ea94456 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
International Journal of Environmental Research and Public Health, Vol 17, Iss 3, p 926 (2020) |
op_relation |
https://www.mdpi.com/1660-4601/17/3/926 https://doaj.org/toc/1660-4601 1660-4601 doi:10.3390/ijerph17030926 https://doaj.org/article/71056fcb0e0741b0af01aa032ea94456 |
op_doi |
https://doi.org/10.3390/ijerph17030926 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
17 |
container_issue |
3 |
container_start_page |
926 |
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1766341313077182464 |