High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia.
BACKGROUND: The threadworm, Strongyloides stercoralis, endemic in tropical and temperate climates, is a neglected tropical disease. Its diagnosis requires specific methods, and accurate information on its geographic distribution and global burden are lacking. We predicted prevalence, using Bayesian...
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ftdoajarticles:oai:doaj.org/article:70b0025a6eb24e1faa1a0f10d389ccb0 2023-05-15T15:16:35+02:00 High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. Virak Khieu Fabian Schär Armelle Forrer Jan Hattendorf Hanspeter Marti Socheat Duong Penelope Vounatsou Sinuon Muth Peter Odermatt 2014-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002854 https://doaj.org/article/70b0025a6eb24e1faa1a0f10d389ccb0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4055527?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002854 https://doaj.org/article/70b0025a6eb24e1faa1a0f10d389ccb0 PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2854 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002854 2022-12-31T08:17:08Z BACKGROUND: The threadworm, Strongyloides stercoralis, endemic in tropical and temperate climates, is a neglected tropical disease. Its diagnosis requires specific methods, and accurate information on its geographic distribution and global burden are lacking. We predicted prevalence, using Bayesian geostatistical modeling, and determined risk factors in northern Cambodia. METHODS: From February to June 2010, we performed a cross-sectional study among 2,396 participants from 60 villages in Preah Vihear Province, northern Cambodia. Two stool specimens per participant were examined using Koga agar plate culture and the Baermann method for detecting S. stercoralis infection. Environmental data was linked to parasitological and questionnaire data by location. Bayesian mixed logistic models were used to explore the spatial correlation of S. stercoralis infection risk. Bayesian Kriging was employed to predict risk at non-surveyed locations. PRINCIPAL FINDINGS: Of the 2,396 participants, 44.7% were infected with S. stercoralis. Of 1,071 strongyloidiasis cases, 339 (31.6%) were among schoolchildren and 425 (39.7%) were found in individuals under 16 years. The incidence of S. stercoralis infection statistically increased with age. Infection among male participants was significantly higher than among females (OR: 1.7; 95% CI: 1.4-2.0; P<0.001). Participants who defecated in latrines were infected significantly less than those who did not (OR: 0.6; 95% CI: 0.4-0.8; P=0.001). Strongyloidiasis cases would be reduced by 39% if all participants defecated in latrines. Incidence of S. stercoralis infections did not show a strong tendency toward spatial clustering in this province. The risk of infection significantly decreased with increasing rainfall and soil organic carbon content, and increased in areas with rice fields. CONCLUSIONS/SIGNIFICANCE: Prevalence of S. stercoralis in rural Cambodia is very high and school-aged children and adults over 45 years were the most at risk for infection. Lack of access to adequate ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 6 e2854 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Virak Khieu Fabian Schär Armelle Forrer Jan Hattendorf Hanspeter Marti Socheat Duong Penelope Vounatsou Sinuon Muth Peter Odermatt High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: The threadworm, Strongyloides stercoralis, endemic in tropical and temperate climates, is a neglected tropical disease. Its diagnosis requires specific methods, and accurate information on its geographic distribution and global burden are lacking. We predicted prevalence, using Bayesian geostatistical modeling, and determined risk factors in northern Cambodia. METHODS: From February to June 2010, we performed a cross-sectional study among 2,396 participants from 60 villages in Preah Vihear Province, northern Cambodia. Two stool specimens per participant were examined using Koga agar plate culture and the Baermann method for detecting S. stercoralis infection. Environmental data was linked to parasitological and questionnaire data by location. Bayesian mixed logistic models were used to explore the spatial correlation of S. stercoralis infection risk. Bayesian Kriging was employed to predict risk at non-surveyed locations. PRINCIPAL FINDINGS: Of the 2,396 participants, 44.7% were infected with S. stercoralis. Of 1,071 strongyloidiasis cases, 339 (31.6%) were among schoolchildren and 425 (39.7%) were found in individuals under 16 years. The incidence of S. stercoralis infection statistically increased with age. Infection among male participants was significantly higher than among females (OR: 1.7; 95% CI: 1.4-2.0; P<0.001). Participants who defecated in latrines were infected significantly less than those who did not (OR: 0.6; 95% CI: 0.4-0.8; P=0.001). Strongyloidiasis cases would be reduced by 39% if all participants defecated in latrines. Incidence of S. stercoralis infections did not show a strong tendency toward spatial clustering in this province. The risk of infection significantly decreased with increasing rainfall and soil organic carbon content, and increased in areas with rice fields. CONCLUSIONS/SIGNIFICANCE: Prevalence of S. stercoralis in rural Cambodia is very high and school-aged children and adults over 45 years were the most at risk for infection. Lack of access to adequate ... |
format |
Article in Journal/Newspaper |
author |
Virak Khieu Fabian Schär Armelle Forrer Jan Hattendorf Hanspeter Marti Socheat Duong Penelope Vounatsou Sinuon Muth Peter Odermatt |
author_facet |
Virak Khieu Fabian Schär Armelle Forrer Jan Hattendorf Hanspeter Marti Socheat Duong Penelope Vounatsou Sinuon Muth Peter Odermatt |
author_sort |
Virak Khieu |
title |
High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
title_short |
High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
title_full |
High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
title_fullStr |
High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
title_full_unstemmed |
High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia. |
title_sort |
high prevalence and spatial distribution of strongyloides stercoralis in rural cambodia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002854 https://doaj.org/article/70b0025a6eb24e1faa1a0f10d389ccb0 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2854 (2014) |
op_relation |
http://europepmc.org/articles/PMC4055527?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002854 https://doaj.org/article/70b0025a6eb24e1faa1a0f10d389ccb0 |
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https://doi.org/10.1371/journal.pntd.0002854 |
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PLoS Neglected Tropical Diseases |
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6 |
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