Isoimperatorin alleviates acetic acid–induced colitis in rats

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Goodarzi Saied, Abdolghaffari Amir Hossein, Najafi Behnaz, Pirali Hamedani Mostafa, Tavakoli Saeed, Marvi Mahshad, Baeeri Maryam, Yassa Narguess, Hadjiakhoondi Abbas, Abdollahi Mohammad, Tofighi Zahra
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2024
• Subjects: isoimperatorin; inflammatory bowel disease; acetic acid; colitis; tnf-α; il-1β; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.4103/apjtb.apjtb_851_23; https://doaj.org/article/707f175781a743e7983db52cb7b78a5c

Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.