CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA
The reactivation of Chagas disease in HIV infected patients presents high mortality and morbidity. We present the case of a female patient with confirmed Chagasic meningoencephalitis as AIDS-defining illness. Interestingly, her TCD4+ lymphocyte cell count was 318 cells/mm3. After two months of induc...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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ftdoajarticles:oai:doaj.org/article:7064c43f07f549b7973bc52a8f05a724 2024-09-09T19:25:18+00:00 CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA Renata BUCCHERI Maria José KASSAB Vera Lucia Teixeira de FREITAS Sheila Cristina Vicente da SILVA Rita C. BEZERRA Zarifa KHOURY Maria Aparecida SHIKANAI-YASUDA José E. VIDAL 2015-12-01T00:00:00Z https://doi.org/10.1590/S0036-46652015000600014 https://doaj.org/article/7064c43f07f549b7973bc52a8f05a724 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000600531&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652015000600014 https://doaj.org/article/7064c43f07f549b7973bc52a8f05a724 Revista do Instituto de Medicina Tropical de São Paulo, Vol 57, Iss 6, Pp 531-535 (2015) Chagas disease Meningoencephalitis Central nervous system Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2015 ftdoajarticles https://doi.org/10.1590/S0036-46652015000600014 2024-08-05T17:49:30Z The reactivation of Chagas disease in HIV infected patients presents high mortality and morbidity. We present the case of a female patient with confirmed Chagasic meningoencephalitis as AIDS-defining illness. Interestingly, her TCD4+ lymphocyte cell count was 318 cells/mm3. After two months of induction therapy, one year of maintenance with benznidazol, and early introduction of highly active antiretroviral therapy (HAART), the patient had good clinical, parasitological and radiological evolution. We used a qualitative polymerase chain reaction for the monitoring of T. cruzi parasitemia during and after the treatment. We emphasize the potential value of molecular techniques along with clinical and radiological parameters in the follow-up of patients with Chagas disease and HIV infection. Early introduction of HAART, prolonged induction and maintenance of antiparasitic therapy, and its discontinuation are feasible, in the current management of reactivation of Chagas disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 57 6 531 535 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Meningoencephalitis Central nervous system Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chagas disease Meningoencephalitis Central nervous system Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Renata BUCCHERI Maria José KASSAB Vera Lucia Teixeira de FREITAS Sheila Cristina Vicente da SILVA Rita C. BEZERRA Zarifa KHOURY Maria Aparecida SHIKANAI-YASUDA José E. VIDAL CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
topic_facet |
Chagas disease Meningoencephalitis Central nervous system Acquired immunodeficiency syndrome Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The reactivation of Chagas disease in HIV infected patients presents high mortality and morbidity. We present the case of a female patient with confirmed Chagasic meningoencephalitis as AIDS-defining illness. Interestingly, her TCD4+ lymphocyte cell count was 318 cells/mm3. After two months of induction therapy, one year of maintenance with benznidazol, and early introduction of highly active antiretroviral therapy (HAART), the patient had good clinical, parasitological and radiological evolution. We used a qualitative polymerase chain reaction for the monitoring of T. cruzi parasitemia during and after the treatment. We emphasize the potential value of molecular techniques along with clinical and radiological parameters in the follow-up of patients with Chagas disease and HIV infection. Early introduction of HAART, prolonged induction and maintenance of antiparasitic therapy, and its discontinuation are feasible, in the current management of reactivation of Chagas disease. |
format |
Article in Journal/Newspaper |
author |
Renata BUCCHERI Maria José KASSAB Vera Lucia Teixeira de FREITAS Sheila Cristina Vicente da SILVA Rita C. BEZERRA Zarifa KHOURY Maria Aparecida SHIKANAI-YASUDA José E. VIDAL |
author_facet |
Renata BUCCHERI Maria José KASSAB Vera Lucia Teixeira de FREITAS Sheila Cristina Vicente da SILVA Rita C. BEZERRA Zarifa KHOURY Maria Aparecida SHIKANAI-YASUDA José E. VIDAL |
author_sort |
Renata BUCCHERI |
title |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
title_short |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
title_full |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
title_fullStr |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
title_full_unstemmed |
CHAGASIC MENINGOENCEPHALITIS IN AN HIV INFECTED PATIENT WITH MODERATE IMMUNOSUPPRESSION: PROLONGED SURVIVAL AND CHALLENGES IN THE HAART ERA |
title_sort |
chagasic meningoencephalitis in an hiv infected patient with moderate immunosuppression: prolonged survival and challenges in the haart era |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2015 |
url |
https://doi.org/10.1590/S0036-46652015000600014 https://doaj.org/article/7064c43f07f549b7973bc52a8f05a724 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 57, Iss 6, Pp 531-535 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000600531&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652015000600014 https://doaj.org/article/7064c43f07f549b7973bc52a8f05a724 |
op_doi |
https://doi.org/10.1590/S0036-46652015000600014 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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57 |
container_issue |
6 |
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531 |
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535 |
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