Oral rabies vaccination of dogs-Experiences from a field trial in Namibia.
Dog-mediated rabies is responsible for tens of thousands of human deaths annually, and in resource-constrained settings, vaccinating dogs to control the disease at source remains challenging. Currently, rabies elimination efforts rely on mass dog vaccination by the parenteral route. To increase the...
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Online Access: | https://doi.org/10.1371/journal.pntd.0010422 https://doaj.org/article/6fef6e417bb24df18a17da14f3a48c83 |
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ftdoajarticles:oai:doaj.org/article:6fef6e417bb24df18a17da14f3a48c83 2023-05-15T15:13:47+02:00 Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. Conrad Martin Freuling Frank Busch Adriaan Vos Steffen Ortmann Frederic Lohr Nehemia Hedimbi Josephat Peter Herman Adimba Nelson Kenneth Shoombe Albertina Shilongo Brighton Gorejena Lukas Kaholongo Siegfried Khaiseb Jolandie van der Westhuizen Klaas Dietze Goi Geurtse Thomas Müller 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010422 https://doaj.org/article/6fef6e417bb24df18a17da14f3a48c83 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010422 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010422 https://doaj.org/article/6fef6e417bb24df18a17da14f3a48c83 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010422 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010422 2022-12-30T20:35:06Z Dog-mediated rabies is responsible for tens of thousands of human deaths annually, and in resource-constrained settings, vaccinating dogs to control the disease at source remains challenging. Currently, rabies elimination efforts rely on mass dog vaccination by the parenteral route. To increase the herd immunity, free-roaming and stray dogs need to be specifically addressed in the vaccination campaigns, with oral rabies vaccination (ORV) of dogs being a possible solution. Using a third-generation vaccine and a standardized egg-flavoured bait, bait uptake and vaccination was assessed under field conditions in Namibia. During this trial, both veterinary staff as well as dog owners expressed their appreciation to this approach of vaccination. Of 1,115 dogs offered a bait, 90% (n = 1,006, 95%CI:91-94) consumed the bait and 72.9% (n = 813, 95%CI:70.2-75.4) of dogs were assessed as being vaccinated by direct observation, while for 11.7% (n = 130, 95%CI:9.9-17.7) the status was recorded as "unkown" and 15.4% (n = 172, 95%CI: 13.4-17.7) were considered as being not vaccinated. Smaller dogs and dogs offered a bait with multiple other dogs had significantly higher vaccination rates, while other factors, e.g. sex, confinement status and time had no influence. The favorable results of this first large-scale field trial further support the strategic integration of ORV into dog rabies control programmes. Given the acceptance of the egg-flavored bait under various settings worldwide, ORV of dogs could become a game-changer in countries, where control strategies using parenteral vaccination alone failed to reach sufficient vaccination coverage in the dog population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 8 e0010422 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Conrad Martin Freuling Frank Busch Adriaan Vos Steffen Ortmann Frederic Lohr Nehemia Hedimbi Josephat Peter Herman Adimba Nelson Kenneth Shoombe Albertina Shilongo Brighton Gorejena Lukas Kaholongo Siegfried Khaiseb Jolandie van der Westhuizen Klaas Dietze Goi Geurtse Thomas Müller Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dog-mediated rabies is responsible for tens of thousands of human deaths annually, and in resource-constrained settings, vaccinating dogs to control the disease at source remains challenging. Currently, rabies elimination efforts rely on mass dog vaccination by the parenteral route. To increase the herd immunity, free-roaming and stray dogs need to be specifically addressed in the vaccination campaigns, with oral rabies vaccination (ORV) of dogs being a possible solution. Using a third-generation vaccine and a standardized egg-flavoured bait, bait uptake and vaccination was assessed under field conditions in Namibia. During this trial, both veterinary staff as well as dog owners expressed their appreciation to this approach of vaccination. Of 1,115 dogs offered a bait, 90% (n = 1,006, 95%CI:91-94) consumed the bait and 72.9% (n = 813, 95%CI:70.2-75.4) of dogs were assessed as being vaccinated by direct observation, while for 11.7% (n = 130, 95%CI:9.9-17.7) the status was recorded as "unkown" and 15.4% (n = 172, 95%CI: 13.4-17.7) were considered as being not vaccinated. Smaller dogs and dogs offered a bait with multiple other dogs had significantly higher vaccination rates, while other factors, e.g. sex, confinement status and time had no influence. The favorable results of this first large-scale field trial further support the strategic integration of ORV into dog rabies control programmes. Given the acceptance of the egg-flavored bait under various settings worldwide, ORV of dogs could become a game-changer in countries, where control strategies using parenteral vaccination alone failed to reach sufficient vaccination coverage in the dog population. |
format |
Article in Journal/Newspaper |
author |
Conrad Martin Freuling Frank Busch Adriaan Vos Steffen Ortmann Frederic Lohr Nehemia Hedimbi Josephat Peter Herman Adimba Nelson Kenneth Shoombe Albertina Shilongo Brighton Gorejena Lukas Kaholongo Siegfried Khaiseb Jolandie van der Westhuizen Klaas Dietze Goi Geurtse Thomas Müller |
author_facet |
Conrad Martin Freuling Frank Busch Adriaan Vos Steffen Ortmann Frederic Lohr Nehemia Hedimbi Josephat Peter Herman Adimba Nelson Kenneth Shoombe Albertina Shilongo Brighton Gorejena Lukas Kaholongo Siegfried Khaiseb Jolandie van der Westhuizen Klaas Dietze Goi Geurtse Thomas Müller |
author_sort |
Conrad Martin Freuling |
title |
Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
title_short |
Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
title_full |
Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
title_fullStr |
Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
title_full_unstemmed |
Oral rabies vaccination of dogs-Experiences from a field trial in Namibia. |
title_sort |
oral rabies vaccination of dogs-experiences from a field trial in namibia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010422 https://doaj.org/article/6fef6e417bb24df18a17da14f3a48c83 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010422 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010422 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010422 https://doaj.org/article/6fef6e417bb24df18a17da14f3a48c83 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010422 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
8 |
container_start_page |
e0010422 |
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