Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.
Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and inclu...
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ftdoajarticles:oai:doaj.org/article:6fb75866c815468cbf176e849d7f44ff 2023-05-15T15:06:58+02:00 Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien 2023-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011127 https://doaj.org/article/6fb75866c815468cbf176e849d7f44ff EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011127 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011127 https://doaj.org/article/6fb75866c815468cbf176e849d7f44ff PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011127 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011127 2023-03-19T01:44:55Z Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 3 e0011127 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. |
format |
Article in Journal/Newspaper |
author |
Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
author_facet |
Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
author_sort |
Hsin-I Shih |
title |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
title_short |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
title_full |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
title_fullStr |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
title_full_unstemmed |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
title_sort |
re-examination of the risk of autoimmune diseases after dengue virus infection: a population-based cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011127 https://doaj.org/article/6fb75866c815468cbf176e849d7f44ff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011127 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011127 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011127 https://doaj.org/article/6fb75866c815468cbf176e849d7f44ff |
op_doi |
https://doi.org/10.1371/journal.pntd.0011127 |
container_title |
PLOS Neglected Tropical Diseases |
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17 |
container_issue |
3 |
container_start_page |
e0011127 |
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1766338551833690112 |