Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties
Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan. Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus (T. atlanticus), Thymus satureioides and Thymus zygis (T. zygis)] were screened for thei...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2015
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Online Access: | https://doi.org/10.1016/j.apjtb.2015.05.011 https://doaj.org/article/6f929e6e9e354037aef5e8931ee4f9bc |
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ftdoajarticles:oai:doaj.org/article:6f929e6e9e354037aef5e8931ee4f9bc 2023-05-15T15:13:35+02:00 Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem 2015-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.05.011 https://doaj.org/article/6f929e6e9e354037aef5e8931ee4f9bc EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115001094 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.011 https://doaj.org/article/6f929e6e9e354037aef5e8931ee4f9bc Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 636-644 (2015) Anti-inflammatory Coagulation Antioxidant Thyme Polyphenol Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.05.011 2022-12-31T14:05:09Z Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan. Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus (T. atlanticus), Thymus satureioides and Thymus zygis (T. zygis)] were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging, ferric reducing antioxidant power assay, radical scavenging activity method, the inhibition of 2,2'-azobis (2-amidinopropane) dihydrochloride that induces oxidative erythrocyte hemolysis and thiobarbituric acid reactive substances assay. The anti-inflammatory activity of aqueous extracts was evaluated in vivo using croton oil-induced ear edema and carrageenan-induced paw edema in mice and rats, respectively. This extracts were evaluated in vitro for their anticoagulant activity at the different concentrations by partial thromboplastin time and prothrombin time activated. Results: All thyme varieties were found to possess considerable antioxidant activity and potent anti-inflammatory activity in the croton oil-induced edema. Administration of aqueous extracts of two varieties (50 mg/kg) (T. zygis and T. atlanticus) reduced significantly the carrageenan-induced paw edema similar to non-steroidal anti-inflammatory drug (indomethacin, 10 mg/kg). In partial thromboplastin time and prothrombin time tests, T. atlanticus and T. zygis extracts showed the strongest anticoagulant activity. In contrast, Thymus satureioides did not show the anticoagulant activity in these tests. Conclusions: All aqueous extracts possess considerable antioxidant activity and are rich in total polyphenol and flavonoid but they act differently in the process of inflammatory and coagulation studied. This study shows great variability of biological activities in thyme varieties. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 8 636 644 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Anti-inflammatory Coagulation Antioxidant Thyme Polyphenol Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Anti-inflammatory Coagulation Antioxidant Thyme Polyphenol Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
topic_facet |
Anti-inflammatory Coagulation Antioxidant Thyme Polyphenol Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from Moroccan. Methods: The aqueous extracts of tree medicinal plants [Thymus atlanticus (T. atlanticus), Thymus satureioides and Thymus zygis (T. zygis)] were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging, ferric reducing antioxidant power assay, radical scavenging activity method, the inhibition of 2,2'-azobis (2-amidinopropane) dihydrochloride that induces oxidative erythrocyte hemolysis and thiobarbituric acid reactive substances assay. The anti-inflammatory activity of aqueous extracts was evaluated in vivo using croton oil-induced ear edema and carrageenan-induced paw edema in mice and rats, respectively. This extracts were evaluated in vitro for their anticoagulant activity at the different concentrations by partial thromboplastin time and prothrombin time activated. Results: All thyme varieties were found to possess considerable antioxidant activity and potent anti-inflammatory activity in the croton oil-induced edema. Administration of aqueous extracts of two varieties (50 mg/kg) (T. zygis and T. atlanticus) reduced significantly the carrageenan-induced paw edema similar to non-steroidal anti-inflammatory drug (indomethacin, 10 mg/kg). In partial thromboplastin time and prothrombin time tests, T. atlanticus and T. zygis extracts showed the strongest anticoagulant activity. In contrast, Thymus satureioides did not show the anticoagulant activity in these tests. Conclusions: All aqueous extracts possess considerable antioxidant activity and are rich in total polyphenol and flavonoid but they act differently in the process of inflammatory and coagulation studied. This study shows great variability of biological activities in thyme varieties. |
format |
Article in Journal/Newspaper |
author |
Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem |
author_facet |
Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem |
author_sort |
Tarik Khouya |
title |
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
title_short |
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
title_full |
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
title_fullStr |
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
title_full_unstemmed |
Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties |
title_sort |
anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from moroccan thyme varieties |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.05.011 https://doaj.org/article/6f929e6e9e354037aef5e8931ee4f9bc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 8, Pp 636-644 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115001094 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.05.011 https://doaj.org/article/6f929e6e9e354037aef5e8931ee4f9bc |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.05.011 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
8 |
container_start_page |
636 |
op_container_end_page |
644 |
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1766344118139617280 |