Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso
Abstract Background In the current context of tailoring interventions to maximize impact, it is important that current data of clinical epidemiology guide public health programmes and health workers in the management of severe disease. This study aimed at describing the burden of severe malaria at h...
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Online Access: | https://doi.org/10.1186/s12936-022-04433-x https://doaj.org/article/6f7c64a88c98486b9d57c37966fe93d6 |
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ftdoajarticles:oai:doaj.org/article:6f7c64a88c98486b9d57c37966fe93d6 2023-05-15T15:17:21+02:00 Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso Alfred B. Tiono Amadou T. Konaté Désiré Kargougou Amidou Diarra Issa Nébié Ouedraogo Amidou Ouedraogo Franco Pagnoni David Modiano Sodiomon B. Sirima 2023-01-01T00:00:00Z https://doi.org/10.1186/s12936-022-04433-x https://doaj.org/article/6f7c64a88c98486b9d57c37966fe93d6 EN eng BMC https://doi.org/10.1186/s12936-022-04433-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04433-x 1475-2875 https://doaj.org/article/6f7c64a88c98486b9d57c37966fe93d6 Malaria Journal, Vol 22, Iss 1, Pp 1-9 (2023) Severe malaria Admission Children Transmission zone Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-022-04433-x 2023-01-15T01:29:42Z Abstract Background In the current context of tailoring interventions to maximize impact, it is important that current data of clinical epidemiology guide public health programmes and health workers in the management of severe disease. This study aimed at describing the burden of severe malaria at hospital level in two areas with distinct malaria transmission intensity. Methods A hospital-based surveillance was established in two regional hospitals located in two areas exposed to different malaria transmission. Data on paediatric severe malaria admissions were recorded using standardized methods from August 2017 to August 2018 with an interruption during the dry season from April to June 2018. Results In total, 921 children with severe malaria cases were enrolled in the study. The mean age was 33.9 (± 1.3) and 36.8 (± 1.6) months in lower malaria transmission (LMT) and higher malaria transmission (HMT) areas (p = 0.15), respectively. The geometric mean of asexual P. falciparum density was significantly higher in the LMT area compared to the HMT area: 22,861 trophozoites/µL (95% CI 17,009.2–30,726.8) vs 11,291.9 trophozoites/µL (95% CI 8577.9–14,864.5). Among enrolled cases, coma was present in 70 (9.2%) participants. 196 patients (21.8%) presented with two or more convulsions episodes prior to admission. Severe anaemia was present in 448 children (49.2%). Other clinical features recorded included 184 (19.9%) cases of lethargy, 99 (10.7%) children with incoercible vomiting, 80 (8.9%) patients with haemoglobinuria, 43 (4.8%) children with severe hypoglycaemia, 37 (4.0%) cases where child was unable to drink/suck, 11 (1.2%) cases of patients with circulatory collapse/shock, and 8 cases (0.9%) of abnormal bleeding (epistaxis). The adjusted odds of presenting with coma, respiratory distress, haemoglobinuria, circulatory collapse/shock and hypoglycaemia were significantly higher (respectively 6.5 (95%CI 3.4–12.1); 1.8 (95%CI 1.0–3.2); 2.7 (95%CI 1.6–4.3); 5.9 (95%CI 1.3–27.9); 1.9 (95%CI 1.0–3.6)) in children living ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Severe malaria Admission Children Transmission zone Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Severe malaria Admission Children Transmission zone Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Alfred B. Tiono Amadou T. Konaté Désiré Kargougou Amidou Diarra Issa Nébié Ouedraogo Amidou Ouedraogo Franco Pagnoni David Modiano Sodiomon B. Sirima Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
topic_facet |
Severe malaria Admission Children Transmission zone Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In the current context of tailoring interventions to maximize impact, it is important that current data of clinical epidemiology guide public health programmes and health workers in the management of severe disease. This study aimed at describing the burden of severe malaria at hospital level in two areas with distinct malaria transmission intensity. Methods A hospital-based surveillance was established in two regional hospitals located in two areas exposed to different malaria transmission. Data on paediatric severe malaria admissions were recorded using standardized methods from August 2017 to August 2018 with an interruption during the dry season from April to June 2018. Results In total, 921 children with severe malaria cases were enrolled in the study. The mean age was 33.9 (± 1.3) and 36.8 (± 1.6) months in lower malaria transmission (LMT) and higher malaria transmission (HMT) areas (p = 0.15), respectively. The geometric mean of asexual P. falciparum density was significantly higher in the LMT area compared to the HMT area: 22,861 trophozoites/µL (95% CI 17,009.2–30,726.8) vs 11,291.9 trophozoites/µL (95% CI 8577.9–14,864.5). Among enrolled cases, coma was present in 70 (9.2%) participants. 196 patients (21.8%) presented with two or more convulsions episodes prior to admission. Severe anaemia was present in 448 children (49.2%). Other clinical features recorded included 184 (19.9%) cases of lethargy, 99 (10.7%) children with incoercible vomiting, 80 (8.9%) patients with haemoglobinuria, 43 (4.8%) children with severe hypoglycaemia, 37 (4.0%) cases where child was unable to drink/suck, 11 (1.2%) cases of patients with circulatory collapse/shock, and 8 cases (0.9%) of abnormal bleeding (epistaxis). The adjusted odds of presenting with coma, respiratory distress, haemoglobinuria, circulatory collapse/shock and hypoglycaemia were significantly higher (respectively 6.5 (95%CI 3.4–12.1); 1.8 (95%CI 1.0–3.2); 2.7 (95%CI 1.6–4.3); 5.9 (95%CI 1.3–27.9); 1.9 (95%CI 1.0–3.6)) in children living ... |
format |
Article in Journal/Newspaper |
author |
Alfred B. Tiono Amadou T. Konaté Désiré Kargougou Amidou Diarra Issa Nébié Ouedraogo Amidou Ouedraogo Franco Pagnoni David Modiano Sodiomon B. Sirima |
author_facet |
Alfred B. Tiono Amadou T. Konaté Désiré Kargougou Amidou Diarra Issa Nébié Ouedraogo Amidou Ouedraogo Franco Pagnoni David Modiano Sodiomon B. Sirima |
author_sort |
Alfred B. Tiono |
title |
Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
title_short |
Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
title_full |
Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
title_fullStr |
Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
title_full_unstemmed |
Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso |
title_sort |
hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of burkina faso |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-022-04433-x https://doaj.org/article/6f7c64a88c98486b9d57c37966fe93d6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-9 (2023) |
op_relation |
https://doi.org/10.1186/s12936-022-04433-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04433-x 1475-2875 https://doaj.org/article/6f7c64a88c98486b9d57c37966fe93d6 |
op_doi |
https://doi.org/10.1186/s12936-022-04433-x |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
_version_ |
1766347595630772224 |