Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts

• Published in: International Journal of Biomedicine
• Main Authors: Nadezhda I. Pavlova, Khariton A. Kurtanov, PhD, Aleksandra T. Diakonova, Natalia A. Solovyeva, Ljubov' Ah. Sydykova, Yulia A. Solovyeva
• Format: Article in Journal/Newspaper
• Language: English
• Published: International Medical Research and Development Corporation 2019
• Subjects: BMI; obesity; FTO; DAT1; eating disorders; Medicine; R; Yakutia; Yakuts
• Online Access: https://doi.org/10.21103/Article9(3)_OA4; https://doaj.org/article/6f763f9b19b1400381aabd9338c92a51

The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of subjects were formed: the control group (CG) with BMI˂25 kg/m2 and the obesity group (OG) with BMI≥30 kg/m2. The study of the FTO rs9939609 SNP and the DAT1 rs27072 SNP was performed by PCR and restriction fragment length polymorphism. Results: According to the results obtained from all persons surveyed, the frequency of the A risk allele of the FTO rs9939609 SNP was 27% with the AA genotype frequency of 9.4%. Analysis of the distribution of alleles and genotypes of the DAT1 rs27072 SNP showed the predominance of the wild-type G allele (90.8%) and the GG genotype in all groups (82.7%). Thus, in the Yakut population, a reliable relationship was found between the carriage of the A risk allele of the FTO SNP rs9939609 SNP with obesity and the degree of obesity. A significantly higher BMI was found in carriers of the wild-type G allele of the DAT1 rs27072 SNP, both in the heterozygous and homozygous forms than in the carriers of the homozygous AA genotype, which is probably related to the small number of people studied and requires careful research on larger samples of populations of Yakutia.