Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts
The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of su...
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ftdoajarticles:oai:doaj.org/article:6f763f9b19b1400381aabd9338c92a51 2023-05-15T18:45:06+02:00 Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva 2019-09-01T00:00:00Z https://doi.org/10.21103/Article9(3)_OA4 https://doaj.org/article/6f763f9b19b1400381aabd9338c92a51 EN eng International Medical Research and Development Corporation http://ijbm.org/articles/i35/ijbm_9(3)_oa4.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(3)_OA4 2158-0510 2158-0529 https://doaj.org/article/6f763f9b19b1400381aabd9338c92a51 International Journal of Biomedicine, Vol 9, Iss 3, Pp 210-215 (2019) BMI obesity FTO DAT1 eating disorders Medicine R article 2019 ftdoajarticles https://doi.org/10.21103/Article9(3)_OA4 2022-12-31T06:04:36Z The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of subjects were formed: the control group (CG) with BMI˂25 kg/m2 and the obesity group (OG) with BMI≥30 kg/m2. The study of the FTO rs9939609 SNP and the DAT1 rs27072 SNP was performed by PCR and restriction fragment length polymorphism. Results: According to the results obtained from all persons surveyed, the frequency of the A risk allele of the FTO rs9939609 SNP was 27% with the AA genotype frequency of 9.4%. Analysis of the distribution of alleles and genotypes of the DAT1 rs27072 SNP showed the predominance of the wild-type G allele (90.8%) and the GG genotype in all groups (82.7%). Thus, in the Yakut population, a reliable relationship was found between the carriage of the A risk allele of the FTO SNP rs9939609 SNP with obesity and the degree of obesity. A significantly higher BMI was found in carriers of the wild-type G allele of the DAT1 rs27072 SNP, both in the heterozygous and homozygous forms than in the carriers of the homozygous AA genotype, which is probably related to the small number of people studied and requires careful research on larger samples of populations of Yakutia. Article in Journal/Newspaper Yakutia Yakuts Directory of Open Access Journals: DOAJ Articles International Journal of Biomedicine 9 3 210 215 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
BMI obesity FTO DAT1 eating disorders Medicine R |
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BMI obesity FTO DAT1 eating disorders Medicine R Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
topic_facet |
BMI obesity FTO DAT1 eating disorders Medicine R |
description |
The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of subjects were formed: the control group (CG) with BMI˂25 kg/m2 and the obesity group (OG) with BMI≥30 kg/m2. The study of the FTO rs9939609 SNP and the DAT1 rs27072 SNP was performed by PCR and restriction fragment length polymorphism. Results: According to the results obtained from all persons surveyed, the frequency of the A risk allele of the FTO rs9939609 SNP was 27% with the AA genotype frequency of 9.4%. Analysis of the distribution of alleles and genotypes of the DAT1 rs27072 SNP showed the predominance of the wild-type G allele (90.8%) and the GG genotype in all groups (82.7%). Thus, in the Yakut population, a reliable relationship was found between the carriage of the A risk allele of the FTO SNP rs9939609 SNP with obesity and the degree of obesity. A significantly higher BMI was found in carriers of the wild-type G allele of the DAT1 rs27072 SNP, both in the heterozygous and homozygous forms than in the carriers of the homozygous AA genotype, which is probably related to the small number of people studied and requires careful research on larger samples of populations of Yakutia. |
format |
Article in Journal/Newspaper |
author |
Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva |
author_facet |
Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva |
author_sort |
Nadezhda I. Pavlova |
title |
Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
title_short |
Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
title_full |
Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
title_fullStr |
Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
title_full_unstemmed |
Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
title_sort |
interrelation of the fto rs9939609 snp and the dat1 rs27072 snp with body mass index and degree of obesity in the population of yakuts |
publisher |
International Medical Research and Development Corporation |
publishDate |
2019 |
url |
https://doi.org/10.21103/Article9(3)_OA4 https://doaj.org/article/6f763f9b19b1400381aabd9338c92a51 |
genre |
Yakutia Yakuts |
genre_facet |
Yakutia Yakuts |
op_source |
International Journal of Biomedicine, Vol 9, Iss 3, Pp 210-215 (2019) |
op_relation |
http://ijbm.org/articles/i35/ijbm_9(3)_oa4.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(3)_OA4 2158-0510 2158-0529 https://doaj.org/article/6f763f9b19b1400381aabd9338c92a51 |
op_doi |
https://doi.org/10.21103/Article9(3)_OA4 |
container_title |
International Journal of Biomedicine |
container_volume |
9 |
container_issue |
3 |
container_start_page |
210 |
op_container_end_page |
215 |
_version_ |
1766236071834681344 |