Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis
INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinoc...
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Online Access: | https://doi.org/10.1590/S0037-86822012000600020 https://doaj.org/article/6f67101d8c90452e96e024aab056404a |
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ftdoajarticles:oai:doaj.org/article:6f67101d8c90452e96e024aab056404a 2023-05-15T15:01:19+02:00 Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis Elizabeth de Souza Neves André Luis Land Curi Maira Cavalcanti de Albuquerque Cassius Schnel Palhano-Silva Laura Berriel da Silva Wendy Fernandes Bueno Maria Regina dos Reis Amendoeira Maria da Gloria Bonecini-Almeida Octavio Fernandes 2012-12-01T00:00:00Z https://doi.org/10.1590/S0037-86822012000600020 https://doaj.org/article/6f67101d8c90452e96e024aab056404a EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600020&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000600020 https://doaj.org/article/6f67101d8c90452e96e024aab056404a Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 6, Pp 757-760 (2012) Toxoplasmose Interferon-gama Retinocoroidite Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1590/S0037-86822012000600020 2022-12-31T02:44:20Z INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 45 6 757 760 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Toxoplasmose Interferon-gama Retinocoroidite Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Toxoplasmose Interferon-gama Retinocoroidite Arctic medicine. Tropical medicine RC955-962 Elizabeth de Souza Neves André Luis Land Curi Maira Cavalcanti de Albuquerque Cassius Schnel Palhano-Silva Laura Berriel da Silva Wendy Fernandes Bueno Maria Regina dos Reis Amendoeira Maria da Gloria Bonecini-Almeida Octavio Fernandes Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
topic_facet |
Toxoplasmose Interferon-gama Retinocoroidite Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis. |
format |
Article in Journal/Newspaper |
author |
Elizabeth de Souza Neves André Luis Land Curi Maira Cavalcanti de Albuquerque Cassius Schnel Palhano-Silva Laura Berriel da Silva Wendy Fernandes Bueno Maria Regina dos Reis Amendoeira Maria da Gloria Bonecini-Almeida Octavio Fernandes |
author_facet |
Elizabeth de Souza Neves André Luis Land Curi Maira Cavalcanti de Albuquerque Cassius Schnel Palhano-Silva Laura Berriel da Silva Wendy Fernandes Bueno Maria Regina dos Reis Amendoeira Maria da Gloria Bonecini-Almeida Octavio Fernandes |
author_sort |
Elizabeth de Souza Neves |
title |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
title_short |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
title_full |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
title_fullStr |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
title_full_unstemmed |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
title_sort |
genetic polymorphism for ifnγ +874t/a in patients with acute toxoplasmosis |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0037-86822012000600020 https://doaj.org/article/6f67101d8c90452e96e024aab056404a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 6, Pp 757-760 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600020&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000600020 https://doaj.org/article/6f67101d8c90452e96e024aab056404a |
op_doi |
https://doi.org/10.1590/S0037-86822012000600020 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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45 |
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