Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Elizabeth de Souza Neves, André Luis Land Curi, Maira Cavalcanti de Albuquerque, Cassius Schnel Palhano-Silva, Laura Berriel da Silva, Wendy Fernandes Bueno, Maria Regina dos Reis Amendoeira, Maria da Gloria Bonecini-Almeida, Octavio Fernandes
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2012
• Subjects: Toxoplasmose; Interferon-gama; Retinocoroidite; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86822012000600020; https://doaj.org/article/6f67101d8c90452e96e024aab056404a

INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.