Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence.
Leptospirosis is the most widespread zoonosis. Chronic human infection and asymptomatic colonization have been reported. However, renal involvement in those with leptospira chronic exposure remains undetermined.In 2007, a multistage sampling survey for chronic kidney disease (CKD) was conducted in a...
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ftdoajarticles:oai:doaj.org/article:6f26a71f0c234acba7b5436a4d9bb91e 2023-05-15T15:11:58+02:00 Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. Huang-Yu Yang Cheng-Chieh Hung Su-Hsun Liu Yi-Gen Guo Yung-Chang Chen Yi-Ching Ko Chiung-Tseng Huang Li-Fang Chou Ya-Chung Tian Ming-Yang Chang Hsiang-Hao Hsu Ming-Yen Lin Shang-Jyh Hwang Chih-Wei Yang 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004105 https://doaj.org/article/6f26a71f0c234acba7b5436a4d9bb91e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4599860?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004105 https://doaj.org/article/6f26a71f0c234acba7b5436a4d9bb91e PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004105 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004105 2022-12-31T15:20:11Z Leptospirosis is the most widespread zoonosis. Chronic human infection and asymptomatic colonization have been reported. However, renal involvement in those with leptospira chronic exposure remains undetermined.In 2007, a multistage sampling survey for chronic kidney disease (CKD) was conducted in a southern county of Taiwan, an area with a high prevalence of dialysis. Additionally, an independent cohort of 88 participants from a leptospira-endemic town was followed for two years after a flooding in 2009. Risks of CKD, stages of CKD, associated risk factors as well as kidney injury markers were compared among adults with anti-leptospira antibody as defined by titers of microscopic agglutination test (MAT). Of 3045 survey participants, the individuals with previous leptospira exposure disclosed a lower level of eGFR (98.3 ± 0.4 vs 100.8 ± 0.6 ml/min per 1.73 m2, P < 0.001) and a higher percentage of CKD, particularly at stage 3a-5 (14.4% vs 8.5%), than those without leptospira exposure. Multivariable linear regression analyses indicated the association of leptospiral infection and lower eGFR (95% CI -4.15 to -1.93, P < 0.001). In a leptospiral endemic town, subjects with a MAT titer ≥ 400 showed a decreased eGFR and higher urinary kidney injury molecule-1 creatinine ratio (KIM1/Cr) level as compared with those having lower titers of MAT (P < 0.05). Furthermore, two participants with persistently high MAT titers had positive urine leptospira DNA and deteriorating renal function.Our data are the first to show that chronic human exposure of leptospirosis is associated significantly with prevalence and severity of CKD and may lead to deterioration of renal function. This study also shed light on the search of underlying factors in areas experiencing CKD of unknown aetiology (CKDu) such as Mesoamerican Nephropathy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 10 e0004105 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Huang-Yu Yang Cheng-Chieh Hung Su-Hsun Liu Yi-Gen Guo Yung-Chang Chen Yi-Ching Ko Chiung-Tseng Huang Li-Fang Chou Ya-Chung Tian Ming-Yang Chang Hsiang-Hao Hsu Ming-Yen Lin Shang-Jyh Hwang Chih-Wei Yang Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leptospirosis is the most widespread zoonosis. Chronic human infection and asymptomatic colonization have been reported. However, renal involvement in those with leptospira chronic exposure remains undetermined.In 2007, a multistage sampling survey for chronic kidney disease (CKD) was conducted in a southern county of Taiwan, an area with a high prevalence of dialysis. Additionally, an independent cohort of 88 participants from a leptospira-endemic town was followed for two years after a flooding in 2009. Risks of CKD, stages of CKD, associated risk factors as well as kidney injury markers were compared among adults with anti-leptospira antibody as defined by titers of microscopic agglutination test (MAT). Of 3045 survey participants, the individuals with previous leptospira exposure disclosed a lower level of eGFR (98.3 ± 0.4 vs 100.8 ± 0.6 ml/min per 1.73 m2, P < 0.001) and a higher percentage of CKD, particularly at stage 3a-5 (14.4% vs 8.5%), than those without leptospira exposure. Multivariable linear regression analyses indicated the association of leptospiral infection and lower eGFR (95% CI -4.15 to -1.93, P < 0.001). In a leptospiral endemic town, subjects with a MAT titer ≥ 400 showed a decreased eGFR and higher urinary kidney injury molecule-1 creatinine ratio (KIM1/Cr) level as compared with those having lower titers of MAT (P < 0.05). Furthermore, two participants with persistently high MAT titers had positive urine leptospira DNA and deteriorating renal function.Our data are the first to show that chronic human exposure of leptospirosis is associated significantly with prevalence and severity of CKD and may lead to deterioration of renal function. This study also shed light on the search of underlying factors in areas experiencing CKD of unknown aetiology (CKDu) such as Mesoamerican Nephropathy. |
format |
Article in Journal/Newspaper |
author |
Huang-Yu Yang Cheng-Chieh Hung Su-Hsun Liu Yi-Gen Guo Yung-Chang Chen Yi-Ching Ko Chiung-Tseng Huang Li-Fang Chou Ya-Chung Tian Ming-Yang Chang Hsiang-Hao Hsu Ming-Yen Lin Shang-Jyh Hwang Chih-Wei Yang |
author_facet |
Huang-Yu Yang Cheng-Chieh Hung Su-Hsun Liu Yi-Gen Guo Yung-Chang Chen Yi-Ching Ko Chiung-Tseng Huang Li-Fang Chou Ya-Chung Tian Ming-Yang Chang Hsiang-Hao Hsu Ming-Yen Lin Shang-Jyh Hwang Chih-Wei Yang |
author_sort |
Huang-Yu Yang |
title |
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
title_short |
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
title_full |
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
title_fullStr |
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
title_full_unstemmed |
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. |
title_sort |
overlooked risk for chronic kidney disease after leptospiral infection: a population-based survey and epidemiological cohort evidence. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0004105 https://doaj.org/article/6f26a71f0c234acba7b5436a4d9bb91e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004105 (2015) |
op_relation |
http://europepmc.org/articles/PMC4599860?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004105 https://doaj.org/article/6f26a71f0c234acba7b5436a4d9bb91e |
op_doi |
https://doi.org/10.1371/journal.pntd.0004105 |
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PLOS Neglected Tropical Diseases |
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9 |
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10 |
container_start_page |
e0004105 |
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