The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up.
BACKGROUND:The natural history of ocular Chlamydia trachomatis infections in endemic communities has not been well characterised and is an important determinant of the effectiveness of different mass treatment strategies to prevent blindness due to trachoma. METHODOLOGY/PRINCIPAL FINDINGS:A multista...
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ftdoajarticles:oai:doaj.org/article:6eef3faffe804bf4a4e510f5fce42a53 2023-05-15T15:10:00+02:00 The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. Nicholas C Grassly Michael E Ward Shirley Ferris David C Mabey Robin L Bailey 2008-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000341 https://doaj.org/article/6eef3faffe804bf4a4e510f5fce42a53 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2584235?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000341 https://doaj.org/article/6eef3faffe804bf4a4e510f5fce42a53 PLoS Neglected Tropical Diseases, Vol 2, Iss 12, p e341 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000341 2022-12-31T12:17:05Z BACKGROUND:The natural history of ocular Chlamydia trachomatis infections in endemic communities has not been well characterised and is an important determinant of the effectiveness of different mass treatment strategies to prevent blindness due to trachoma. METHODOLOGY/PRINCIPAL FINDINGS:A multistate hidden Markov model was fitted to data on infection and active disease from 256 untreated villagers in The Gambia who were examined every 2 weeks over a 6-month period. Parameters defining the natural history of trachoma were estimated, and associations between these parameters, demographic and baseline immune measurements examined. The median incubation period following infection was estimated at 17 days (95% confidence interval: 11-28). Disease persisted for longer than infection (median 21 (15-32) weeks) versus 17 (12-24) weeks), with an estimated median duration of post-infection inflammation of 5 (3-8) weeks. The duration of active disease showed a significant decline with age even after accounting for lower rates of re-infection and disease at older ages (p = 0.004). Measurements of levels of baseline IgA to epitopes in the major outer membrane protein of Chlamydia trachomatis were not significantly correlated with protection or more rapid clearance of infection. CONCLUSIONS:The average duration of infection with Chlamydia trachomatis especially at younger ages is long. This contributes to the persistence and gradual return of trachoma after community-wide treatment with antibiotics. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 12 e341 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nicholas C Grassly Michael E Ward Shirley Ferris David C Mabey Robin L Bailey The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The natural history of ocular Chlamydia trachomatis infections in endemic communities has not been well characterised and is an important determinant of the effectiveness of different mass treatment strategies to prevent blindness due to trachoma. METHODOLOGY/PRINCIPAL FINDINGS:A multistate hidden Markov model was fitted to data on infection and active disease from 256 untreated villagers in The Gambia who were examined every 2 weeks over a 6-month period. Parameters defining the natural history of trachoma were estimated, and associations between these parameters, demographic and baseline immune measurements examined. The median incubation period following infection was estimated at 17 days (95% confidence interval: 11-28). Disease persisted for longer than infection (median 21 (15-32) weeks) versus 17 (12-24) weeks), with an estimated median duration of post-infection inflammation of 5 (3-8) weeks. The duration of active disease showed a significant decline with age even after accounting for lower rates of re-infection and disease at older ages (p = 0.004). Measurements of levels of baseline IgA to epitopes in the major outer membrane protein of Chlamydia trachomatis were not significantly correlated with protection or more rapid clearance of infection. CONCLUSIONS:The average duration of infection with Chlamydia trachomatis especially at younger ages is long. This contributes to the persistence and gradual return of trachoma after community-wide treatment with antibiotics. |
format |
Article in Journal/Newspaper |
author |
Nicholas C Grassly Michael E Ward Shirley Ferris David C Mabey Robin L Bailey |
author_facet |
Nicholas C Grassly Michael E Ward Shirley Ferris David C Mabey Robin L Bailey |
author_sort |
Nicholas C Grassly |
title |
The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
title_short |
The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
title_full |
The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
title_fullStr |
The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
title_full_unstemmed |
The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. |
title_sort |
natural history of trachoma infection and disease in a gambian cohort with frequent follow-up. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000341 https://doaj.org/article/6eef3faffe804bf4a4e510f5fce42a53 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 12, p e341 (2008) |
op_relation |
http://europepmc.org/articles/PMC2584235?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000341 https://doaj.org/article/6eef3faffe804bf4a4e510f5fce42a53 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000341 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
2 |
container_issue |
12 |
container_start_page |
e341 |
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1766341085756391424 |