Alternative Animal Models of Aging Research
Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of usin...
Published in: | Frontiers in Molecular Biosciences |
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2021
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Online Access: | https://doi.org/10.3389/fmolb.2021.660959 https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3 |
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ftdoajarticles:oai:doaj.org/article:6ee18a652b7f4283a8c8e75e4184a1c3 2023-05-15T15:22:34+02:00 Alternative Animal Models of Aging Research Susanne Holtze Ekaterina Gorshkova Stan Braude Alessandro Cellerino Philip Dammann Thomas B. Hildebrandt Andreas Hoeflich Steve Hoffmann Philipp Koch Eva Terzibasi Tozzini Maxim Skulachev Vladimir P. Skulachev Arne Sahm 2021-05-01T00:00:00Z https://doi.org/10.3389/fmolb.2021.660959 https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fmolb.2021.660959/full https://doaj.org/toc/2296-889X 2296-889X doi:10.3389/fmolb.2021.660959 https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3 Frontiers in Molecular Biosciences, Vol 8 (2021) Senescence Heterocephalus glaber Myotis Nothobranchius furzeri Proteus anguinus Hydra oligactis Biology (General) QH301-705.5 article 2021 ftdoajarticles https://doi.org/10.3389/fmolb.2021.660959 2022-12-31T06:53:23Z Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of using these models are access to resources such as strains with known genetic properties, high-quality genomic and transcriptomic sequencing data, versatile experimental manipulation capabilities including well-established genome editing tools, as well as extensive experience in husbandry. However, this approach may introduce interpretation biases due to the specific characteristics of the investigated species, which may lead to inappropriate, or even false, generalization. For example, it is still unclear to what extent knowledge of aging mechanisms gained in short-lived model organisms is transferable to long-lived species such as humans. In addition, other specific adaptations favoring a long and healthy life from the immense evolutionary toolbox may be entirely missed. In this review, we summarize the specific characteristics of emerging animal models that have attracted the attention of gerontologists, we provide an overview of the available data and resources related to these models, and we summarize important insights gained from them in recent years. The models presented include short-lived ones such as killifish (Nothobranchius furzeri), long-lived ones such as primates (Callithrix jacchus, Cebus imitator, Macaca mulatta), bathyergid mole-rats (Heterocephalus glaber, Fukomys spp.), bats (Myotis spp.), birds, olms (Proteus anguinus), turtles, greenland sharks, bivalves (Arctica islandica), and potentially non-aging ones such as Hydra and Planaria. Article in Journal/Newspaper Arctica islandica Greenland Directory of Open Access Journals: DOAJ Articles Greenland Frontiers in Molecular Biosciences 8 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Senescence Heterocephalus glaber Myotis Nothobranchius furzeri Proteus anguinus Hydra oligactis Biology (General) QH301-705.5 |
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Senescence Heterocephalus glaber Myotis Nothobranchius furzeri Proteus anguinus Hydra oligactis Biology (General) QH301-705.5 Susanne Holtze Ekaterina Gorshkova Stan Braude Alessandro Cellerino Philip Dammann Thomas B. Hildebrandt Andreas Hoeflich Steve Hoffmann Philipp Koch Eva Terzibasi Tozzini Maxim Skulachev Vladimir P. Skulachev Arne Sahm Alternative Animal Models of Aging Research |
topic_facet |
Senescence Heterocephalus glaber Myotis Nothobranchius furzeri Proteus anguinus Hydra oligactis Biology (General) QH301-705.5 |
description |
Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of using these models are access to resources such as strains with known genetic properties, high-quality genomic and transcriptomic sequencing data, versatile experimental manipulation capabilities including well-established genome editing tools, as well as extensive experience in husbandry. However, this approach may introduce interpretation biases due to the specific characteristics of the investigated species, which may lead to inappropriate, or even false, generalization. For example, it is still unclear to what extent knowledge of aging mechanisms gained in short-lived model organisms is transferable to long-lived species such as humans. In addition, other specific adaptations favoring a long and healthy life from the immense evolutionary toolbox may be entirely missed. In this review, we summarize the specific characteristics of emerging animal models that have attracted the attention of gerontologists, we provide an overview of the available data and resources related to these models, and we summarize important insights gained from them in recent years. The models presented include short-lived ones such as killifish (Nothobranchius furzeri), long-lived ones such as primates (Callithrix jacchus, Cebus imitator, Macaca mulatta), bathyergid mole-rats (Heterocephalus glaber, Fukomys spp.), bats (Myotis spp.), birds, olms (Proteus anguinus), turtles, greenland sharks, bivalves (Arctica islandica), and potentially non-aging ones such as Hydra and Planaria. |
format |
Article in Journal/Newspaper |
author |
Susanne Holtze Ekaterina Gorshkova Stan Braude Alessandro Cellerino Philip Dammann Thomas B. Hildebrandt Andreas Hoeflich Steve Hoffmann Philipp Koch Eva Terzibasi Tozzini Maxim Skulachev Vladimir P. Skulachev Arne Sahm |
author_facet |
Susanne Holtze Ekaterina Gorshkova Stan Braude Alessandro Cellerino Philip Dammann Thomas B. Hildebrandt Andreas Hoeflich Steve Hoffmann Philipp Koch Eva Terzibasi Tozzini Maxim Skulachev Vladimir P. Skulachev Arne Sahm |
author_sort |
Susanne Holtze |
title |
Alternative Animal Models of Aging Research |
title_short |
Alternative Animal Models of Aging Research |
title_full |
Alternative Animal Models of Aging Research |
title_fullStr |
Alternative Animal Models of Aging Research |
title_full_unstemmed |
Alternative Animal Models of Aging Research |
title_sort |
alternative animal models of aging research |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doi.org/10.3389/fmolb.2021.660959 https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Arctica islandica Greenland |
genre_facet |
Arctica islandica Greenland |
op_source |
Frontiers in Molecular Biosciences, Vol 8 (2021) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.660959/full https://doaj.org/toc/2296-889X 2296-889X doi:10.3389/fmolb.2021.660959 https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3 |
op_doi |
https://doi.org/10.3389/fmolb.2021.660959 |
container_title |
Frontiers in Molecular Biosciences |
container_volume |
8 |
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1766353212811509760 |