A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela.
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus linked to devastating neurologic diseases. Immune responses to flaviviruses may be pathogenic or protective. Our understanding of human immune responses to ZIKV in vivo remains limited. Therefore, we performed a longitudinal molecular and ph...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0007053 https://doaj.org/article/6eab722f4a094b6dae0d0bb32fb7feb7 |
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ftdoajarticles:oai:doaj.org/article:6eab722f4a094b6dae0d0bb32fb7feb7 2023-05-15T15:06:21+02:00 A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. Aaron F Carlin Jinsheng Wen Edward A Vizcarra Melanie McCauley Antoine Chaillon Kevan Akrami Cheryl Kim Annie Elong Ngono Maria Luz Lara-Marquez Davey M Smith Christopher K Glass Robert T Schooley Christopher Benner Sujan Shresta 2018-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007053 https://doaj.org/article/6eab722f4a094b6dae0d0bb32fb7feb7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6329527?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007053 https://doaj.org/article/6eab722f4a094b6dae0d0bb32fb7feb7 PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0007053 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007053 2022-12-31T09:21:05Z Zika virus (ZIKV) is an emerging mosquito-borne flavivirus linked to devastating neurologic diseases. Immune responses to flaviviruses may be pathogenic or protective. Our understanding of human immune responses to ZIKV in vivo remains limited. Therefore, we performed a longitudinal molecular and phenotypic characterization of innate and adaptive immune responses during an acute ZIKV infection. We found that innate immune transcriptional and genomic responses were both cell type- and time-dependent. While interferon stimulated gene induction was common to all innate immune cells, the upregulation of important inflammatory cytokine genes was primarily limited to monocyte subsets. Additionally, genomic analysis revealed substantial chromatin remodeling at sites containing cell-type specific transcription factor binding motifs that may explain the observed changes in gene expression. In this dengue virus-experienced individual, adaptive immune responses were rapidly mobilized with T cell transcriptional activity and ZIKV neutralizing antibody responses peaking 6 days after the onset of symptoms. Collectively this study characterizes the development and resolution of an in vivo human immune response to acute ZIKV infection in an individual with pre-existing flavivirus immunity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 12 e0007053 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Aaron F Carlin Jinsheng Wen Edward A Vizcarra Melanie McCauley Antoine Chaillon Kevan Akrami Cheryl Kim Annie Elong Ngono Maria Luz Lara-Marquez Davey M Smith Christopher K Glass Robert T Schooley Christopher Benner Sujan Shresta A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus linked to devastating neurologic diseases. Immune responses to flaviviruses may be pathogenic or protective. Our understanding of human immune responses to ZIKV in vivo remains limited. Therefore, we performed a longitudinal molecular and phenotypic characterization of innate and adaptive immune responses during an acute ZIKV infection. We found that innate immune transcriptional and genomic responses were both cell type- and time-dependent. While interferon stimulated gene induction was common to all innate immune cells, the upregulation of important inflammatory cytokine genes was primarily limited to monocyte subsets. Additionally, genomic analysis revealed substantial chromatin remodeling at sites containing cell-type specific transcription factor binding motifs that may explain the observed changes in gene expression. In this dengue virus-experienced individual, adaptive immune responses were rapidly mobilized with T cell transcriptional activity and ZIKV neutralizing antibody responses peaking 6 days after the onset of symptoms. Collectively this study characterizes the development and resolution of an in vivo human immune response to acute ZIKV infection in an individual with pre-existing flavivirus immunity. |
format |
Article in Journal/Newspaper |
author |
Aaron F Carlin Jinsheng Wen Edward A Vizcarra Melanie McCauley Antoine Chaillon Kevan Akrami Cheryl Kim Annie Elong Ngono Maria Luz Lara-Marquez Davey M Smith Christopher K Glass Robert T Schooley Christopher Benner Sujan Shresta |
author_facet |
Aaron F Carlin Jinsheng Wen Edward A Vizcarra Melanie McCauley Antoine Chaillon Kevan Akrami Cheryl Kim Annie Elong Ngono Maria Luz Lara-Marquez Davey M Smith Christopher K Glass Robert T Schooley Christopher Benner Sujan Shresta |
author_sort |
Aaron F Carlin |
title |
A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
title_short |
A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
title_full |
A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
title_fullStr |
A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
title_full_unstemmed |
A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. |
title_sort |
longitudinal systems immunologic investigation of acute zika virus infection in an individual infected while traveling to caracas, venezuela. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0007053 https://doaj.org/article/6eab722f4a094b6dae0d0bb32fb7feb7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0007053 (2018) |
op_relation |
http://europepmc.org/articles/PMC6329527?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007053 https://doaj.org/article/6eab722f4a094b6dae0d0bb32fb7feb7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007053 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
12 |
container_start_page |
e0007053 |
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1766337981741793280 |