Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Mariana Nascimento Pona, Jordhana Mendonça Dietrich, Joselina Maria da Silva, Helen Aguiar Lemes da Silva, Marcia Hueb, Amilcar Sabino Damazo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2021
• Subjects: Cutaneous leishmaniasis; Skin; Macrophage; Apoptosis; Annexin-A1; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0756-2020; https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9

Abstract INTRODUCTION This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.