Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
Abstract INTRODUCTION This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS The number of apoptotic cells was h...
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2021
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Online Access: | https://doi.org/10.1590/0037-8682-0756-2020 https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9 |
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ftdoajarticles:oai:doaj.org/article:6e8367ad5f8045528e29c4e49b0f3ee9 2023-05-15T15:01:16+02:00 Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis Mariana Nascimento Pona Jordhana Mendonça Dietrich Joselina Maria da Silva Helen Aguiar Lemes da Silva Marcia Hueb Amilcar Sabino Damazo 2021-08-01T00:00:00Z https://doi.org/10.1590/0037-8682-0756-2020 https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100654&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0756-2020 https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9 Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) Cutaneous leishmaniasis Skin Macrophage Apoptosis Annexin-A1 Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1590/0037-8682-0756-2020 2022-12-30T21:39:01Z Abstract INTRODUCTION This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 54 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Cutaneous leishmaniasis Skin Macrophage Apoptosis Annexin-A1 Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Cutaneous leishmaniasis Skin Macrophage Apoptosis Annexin-A1 Arctic medicine. Tropical medicine RC955-962 Mariana Nascimento Pona Jordhana Mendonça Dietrich Joselina Maria da Silva Helen Aguiar Lemes da Silva Marcia Hueb Amilcar Sabino Damazo Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
topic_facet |
Cutaneous leishmaniasis Skin Macrophage Apoptosis Annexin-A1 Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis. |
format |
Article in Journal/Newspaper |
author |
Mariana Nascimento Pona Jordhana Mendonça Dietrich Joselina Maria da Silva Helen Aguiar Lemes da Silva Marcia Hueb Amilcar Sabino Damazo |
author_facet |
Mariana Nascimento Pona Jordhana Mendonça Dietrich Joselina Maria da Silva Helen Aguiar Lemes da Silva Marcia Hueb Amilcar Sabino Damazo |
author_sort |
Mariana Nascimento Pona |
title |
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
title_short |
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
title_full |
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
title_fullStr |
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
title_full_unstemmed |
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
title_sort |
analysis of annexin-a1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2021 |
url |
https://doi.org/10.1590/0037-8682-0756-2020 https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100654&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0756-2020 https://doaj.org/article/6e8367ad5f8045528e29c4e49b0f3ee9 |
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https://doi.org/10.1590/0037-8682-0756-2020 |
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Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
54 |
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