Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil.
Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adapta...
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ftdoajarticles:oai:doaj.org/article:6e77f77207a5471b8dfc2f142017df99 2023-05-15T15:13:10+02:00 Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. Ana C P Souto Lucas X Bonfietti Kennio Ferreira-Paim Luciana Trilles Marilena Martins Marcelo Ribeiro-Alves Cau D Pham Liline Martins Wallace Dos Santos Marilene Chang Fabio Brito-Santos Dayane C S Santos Silvana Fortes Shawn R Lockhart Bodo Wanke Márcia S C Melhem Márcia S Lazéra Wieland Meyer 2016-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004885 https://doaj.org/article/6e77f77207a5471b8dfc2f142017df99 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4986980?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004885 https://doaj.org/article/6e77f77207a5471b8dfc2f142017df99 PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004885 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004885 2022-12-31T06:05:41Z Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adaptation to temperate regions was crucial in the species evolution and highlighted the importance of this pathogenic yeast in the context of disease. Cryptococcus gattii molecular type VGII has come to the forefront in connection with an on-going emergence in the Pacific North West of North America. Taking into account that previous work pointed towards South America as an origin of this species, the present work aimed to assess the genetic diversity within the Brazilian C. gattii VGII population in order to gain new insights into its origin and global dispersal from the South American continent using the ISHAM consensus MLST typing scheme. Our results corroborate the finding that the Brazilian C. gattii VGII population is highly diverse. The diversity is likely due to recombination generated from sexual reproduction, as evidenced by the presence of both mating types in clinical and environmental samples. The data presented herein strongly supports the emergence of highly virulent strains from ancestors in the Northern regions of Brazil, Amazonia and the Northeast. Numerous genotypes represent a link between Brazil and other parts of the world reinforcing South America as the most likely origin of the C. gattii VGII subtypes and their subsequent global spread, including their dispersal into North America, where they caused a major emergence. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLOS Neglected Tropical Diseases 10 8 e0004885 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ana C P Souto Lucas X Bonfietti Kennio Ferreira-Paim Luciana Trilles Marilena Martins Marcelo Ribeiro-Alves Cau D Pham Liline Martins Wallace Dos Santos Marilene Chang Fabio Brito-Santos Dayane C S Santos Silvana Fortes Shawn R Lockhart Bodo Wanke Márcia S C Melhem Márcia S Lazéra Wieland Meyer Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adaptation to temperate regions was crucial in the species evolution and highlighted the importance of this pathogenic yeast in the context of disease. Cryptococcus gattii molecular type VGII has come to the forefront in connection with an on-going emergence in the Pacific North West of North America. Taking into account that previous work pointed towards South America as an origin of this species, the present work aimed to assess the genetic diversity within the Brazilian C. gattii VGII population in order to gain new insights into its origin and global dispersal from the South American continent using the ISHAM consensus MLST typing scheme. Our results corroborate the finding that the Brazilian C. gattii VGII population is highly diverse. The diversity is likely due to recombination generated from sexual reproduction, as evidenced by the presence of both mating types in clinical and environmental samples. The data presented herein strongly supports the emergence of highly virulent strains from ancestors in the Northern regions of Brazil, Amazonia and the Northeast. Numerous genotypes represent a link between Brazil and other parts of the world reinforcing South America as the most likely origin of the C. gattii VGII subtypes and their subsequent global spread, including their dispersal into North America, where they caused a major emergence. |
format |
Article in Journal/Newspaper |
author |
Ana C P Souto Lucas X Bonfietti Kennio Ferreira-Paim Luciana Trilles Marilena Martins Marcelo Ribeiro-Alves Cau D Pham Liline Martins Wallace Dos Santos Marilene Chang Fabio Brito-Santos Dayane C S Santos Silvana Fortes Shawn R Lockhart Bodo Wanke Márcia S C Melhem Márcia S Lazéra Wieland Meyer |
author_facet |
Ana C P Souto Lucas X Bonfietti Kennio Ferreira-Paim Luciana Trilles Marilena Martins Marcelo Ribeiro-Alves Cau D Pham Liline Martins Wallace Dos Santos Marilene Chang Fabio Brito-Santos Dayane C S Santos Silvana Fortes Shawn R Lockhart Bodo Wanke Márcia S C Melhem Márcia S Lazéra Wieland Meyer |
author_sort |
Ana C P Souto |
title |
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
title_short |
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
title_full |
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
title_fullStr |
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
title_full_unstemmed |
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil. |
title_sort |
population genetic analysis reveals a high genetic diversity in the brazilian cryptococcus gattii vgii population and shifts the global origin from the amazon rainforest to the semi-arid desert in the northeast of brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004885 https://doaj.org/article/6e77f77207a5471b8dfc2f142017df99 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004885 (2016) |
op_relation |
http://europepmc.org/articles/PMC4986980?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004885 https://doaj.org/article/6e77f77207a5471b8dfc2f142017df99 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004885 |
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PLOS Neglected Tropical Diseases |
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10 |
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e0004885 |
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